Isolation of a unique hepatic stellate cell population expressing integrin α8 from embryonic mouse livers
Sign Up to like & getrecommendations! Published in 2018 at "Developmental Dynamics"
DOI: 10.1002/dvdy.24634
Abstract: Background: Hepatic stellate cells (HSCs) play an important role in liver fibrogenesis. However, little is known about their phenotype and role in liver development. The aim of this study is to identify specific markers for… read more here.
Keywords: liver; perivascular mesenchymal; itga8; mesenchymal cells ... See more keywords
Impact of human mesenchymal cells of different body site origins on the maturation of dermo-epidermal skin substitutes
Sign Up to like & getrecommendations! Published in 2018 at "Pediatric Surgery International"
DOI: 10.1007/s00383-018-4383-5
Abstract: Aim of the studyThe use of autologous bio-engineered dermo-epidermal skin substitutes (DESS) yields a pivotal opportunity to cover large skin defects in human patients. These skin grafts consist of both epidermal and dermal compartments necessary… read more here.
Keywords: dermo epidermal; skin; mesenchymal cells; skin grafts ... See more keywords
Defective circadian control in mesenchymal cells reduces adult bone mass in mice by promoting osteoclast function.
Sign Up to like & getrecommendations! Published in 2019 at "Bone"
DOI: 10.1016/j.bone.2019.01.016
Abstract: Serum bone turnover markers show diurnal variation in humans, suggesting that circadian rhythms contribute to normal bone physiology. This conclusion is corroborated by bone phenotypes in mice with genetic disruption of the circadian molecular clock… read more here.
Keywords: prx1 cre; bmal1f; bone; mice ... See more keywords
PDGFRb+ mesenchymal cells, but not NG2+ mural cells, contribute to cardiac fat.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.108697
Abstract: Understanding cellular origins of cardiac adipocytes (CAs) can offer important implications for the treatment of fat-associated cardiovascular diseases. Here, we perform lineage tracing studies by using various genetic models and find that cardiac mesenchymal cells… read more here.
Keywords: mural cells; pdgfrb mesenchymal; intramyocardial adipocytes; mesenchymal cells ... See more keywords
Structural environment built by AKAP12+ colon mesenchymal cells drives M2 macrophages during inflammation recovery
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep42723
Abstract: Macrophages exhibit phenotypic plasticity, as they have the ability to switch their functional phenotypes during inflammation and recovery. Simultaneously, the mechanical environment actively changes. However, how these dynamic alterations affect the macrophage phenotype is unknown.… read more here.
Keywords: recovery; inflammation recovery; akap12 colon; mesenchymal cells ... See more keywords
Autophagy in PDGFRA+ mesenchymal cells is required for intestinal homeostasis and mammalian survival
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2090694
Abstract: ABSTRACT Macroautophagy/autophagy defects are a risk factor for inflamatory bowel disease (IBD), but the mechanism remains unclear. We previously demonstrated that conditional whole-body deletion of the essential Atg7 (autophagy related 7) gene in adult mice… read more here.
Keywords: deletion; loss; mesenchymal cells; autophagy ... See more keywords
Bioengineered gold nanoparticles targeted to mesenchymal cells from patients with bronchiolitis obliterans syndrome does not rise the inflammatory response and can be safely inhaled by rodents
Sign Up to like & getrecommendations! Published in 2017 at "Nanotoxicology"
DOI: 10.1080/17435390.2017.1317862
Abstract: Abstract The use of gold nanoparticles (GNPs) as drug delivery system represents a promising issue for diseases without effective pharmacological treatment due to insufficient local drug accumulation and excessive systemic toxicity. Bronchiolitis obliterans syndrome (BOS)… read more here.
Keywords: bronchiolitis obliterans; gold nanoparticles; response; obliterans syndrome ... See more keywords
Developmental mechanisms regulating the formation of smooth muscle layers in the mouse uterus †
Sign Up to like & getrecommendations! Published in 2020 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioaa104
Abstract: Abstract Uterine smooth muscle cells differentiate from mesenchymal cells, and gap junctions connect the muscle cells in the myometrium. At the neonatal stage, a uterine smooth muscle layer is situated away from the epithelium when… read more here.
Keywords: developmental mechanisms; muscle; muscle cells; differentiation ... See more keywords
TMIC-58. THE CELLULAR AND MOLECULAR BASIS FOR MESENCHYMAL TRANSFORMATION IN GLIOMAS
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz175.1092
Abstract: Mesenchymal gliomas are the most aggressive tumors that carry the worst prognosis. The origins of mesenchymal cells within brain tumors, remains poorly understood. They could originate either from invading mesenchymal cells, from perivascular smooth muscle… read more here.
Keywords: gliomas; mesenchymal transformation; transformation; progression ... See more keywords
TCDD induces cleft palate through exosomes derived from mesenchymal cells.
Sign Up to like & getrecommendations! Published in 2022 at "Toxicology research"
DOI: 10.1093/toxres/tfac068
Abstract: TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) is a ubiquitous environmental toxicant and a notable teratogenic agent for cleft palate (CP), a common congenital structural malformation that can result from abnormalities during palatal shelf connection and/or fusion. The development of… read more here.
Keywords: tcdd induces; cleft palate; cells tcdd; induces cleft ... See more keywords
EGFR marks a subpopulation of dermal mesenchymal cells highly expressing IGF1 which enhances hair follicle regeneration.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cellular and molecular medicine"
DOI: 10.1111/jcmm.17766
Abstract: The skin harbours transcriptionally and functionally heterogeneous mesenchymal cells that participate in various physiological activities by secreting biochemical cues. In this study, we aimed to identify a new subpopulation of dermal mesenchymal cells that enhance… read more here.
Keywords: subpopulation dermal; subpopulation; hair follicle; follicle regeneration ... See more keywords