131‐Oxophorbine protopheophorbide A from Ziziphus lotus as a novel mesenchymal‐epithelial transition factor receptor inhibitory lead for the control of breast tumor growth in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22874
Abstract: The failure of chemotherapy especially in triple negative breast cancer (TNBC) patients has been correlated with the overexpression of the mesenchymal‐epithelial transition factor (c‐Met) receptor. Thus, the hepatocyte growth factor (HGF)/c‐Met signaling axis has gained… read more here.
Keywords: epithelial transition; transition factor; mesenchymal epithelial; factor ... See more keywords
A mesenchymal to epithelial switch in Fgf10 expression specifies an evolutionary-conserved population of ionocytes in salivary glands.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2022.110663
Abstract: Fibroblast growth factor 10 (FGF10) is well established as a mesenchyme-derived growth factor and a critical regulator of fetal organ development in mice and humans. Using a single-cell RNA sequencing (RNA-seq) atlas of salivary gland… read more here.
Keywords: expression; fgf10pos cells; population; epithelial fgf10pos ... See more keywords
Mesenchymal-epithelial crosstalk shapes intestinal regionalisation via Wnt and Shh signalling
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28369-7
Abstract: Organs are anatomically compartmentalised to cater for specialised functions. In the small intestine (SI), regionalisation enables sequential processing of food and nutrient absorption. While several studies indicate the critical importance of non-epithelial cells during development… read more here.
Keywords: crosstalk shapes; mesenchymal epithelial; regionalisation; epithelial crosstalk ... See more keywords
Mesenchymal–epithelial transition in development and reprogramming
Sign Up to like & getrecommendations! Published in 2019 at "Nature Cell Biology"
DOI: 10.1038/s41556-018-0195-z
Abstract: During organogenesis, epithelial cells can give rise to mesenchymal cells through epithelial–mesenchymal transition. The reverse process, mesenchymal–epithelial transition (MET), can similarly generate epithelial cells. Transitions between epithelial and mesenchymal states are also critical for the… read more here.
Keywords: epithelial transition; transition; development reprogramming; transition development ... See more keywords
Bone Vascular Niche E-selectin Induces Mesenchymal-Epithelial Transition and Wnt Activation in Cancer Cells to Promote Bone Metastasis
Sign Up to like & getrecommendations! Published in 2019 at "Nature cell biology"
DOI: 10.1038/s41556-019-0309-2
Abstract: How disseminated tumour cells engage specific stromal components in distant organs for survival and outgrowth is a critical but poorly understood step of the metastatic cascade. Previous studies have demonstrated the importance of the epithelial–mesenchymal… read more here.
Keywords: epithelial transition; transition; metastasis; bone ... See more keywords
Correlation analysis of mesenchymal–epithelial transition factor protein and human epidermal growth receptor 2 protein expression in 1479 cases of lung adenocarcinoma in China
Sign Up to like & getrecommendations! Published in 2018 at "Thoracic Cancer"
DOI: 10.1111/1759-7714.12595
Abstract: To investigate the correlation between mesenchymal–epithelial transition factor (C‐Met) and human epidermal growth receptor 2 (HER2) protein expression in primary lung adenocarcinoma tissues. read more here.
Keywords: protein; epithelial transition; transition factor; human epidermal ... See more keywords
Phospholipid remodeling is critical for stem cell pluripotency by facilitating mesenchymal-to-epithelial transition
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aax7525
Abstract: Phospholipid-dependent regulation of NF-κB contributes to mesenchymal-to-epithelial transition in pluripotency acquisition. Metabolic reprogramming has emerged as a key regulator of cell fate decisions. Roles of glucose and amino acid metabolism have been extensively documented, whereas… read more here.
Keywords: epithelial transition; cdp etn; pluripotency; mesenchymal epithelial ... See more keywords
Epithelial-to-Mesenchymal and Mesenchymal-to-Epithelial Transition in Mesenchymal Tumors: A Paradox in Sarcomas?
Sign Up to like & getrecommendations! Published in 2017 at "Cancer research"
DOI: 10.1158/0008-5472.can-17-0032
Abstract: The epithelial-to-mesenchymal transition (EMT) is a reversible process comprised of various subprograms via which epithelial cells reduce their intercellular adhesions and proliferative capacity while gaining a mesenchymal phenotype with increased migratory and invasive properties. This… read more here.
Keywords: emt related; transition; epithelial mesenchymal; mesenchymal mesenchymal ... See more keywords
Abstract 2784: Driver genes network promotes mesenchymal to epithelial transition and organ-specific metastasis
Sign Up to like & getrecommendations! Published in 2019 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2019-2784
Abstract: Metastasis, a major characteristic of malignancy, causes high mortality. Accumulating evidence suggests that cancer intends to metastasize to specific organ, however the molecular mechanisms remain unknown. Others and us have demonstrated that epithelial to mesenchymal… read more here.
Keywords: metastasis; driver genes; cell; transition ... See more keywords
Hybrid-based drug design of 1,2,3-triazole-pyrimidine-hybrid derivatives: Efficient inhibiting agents of mesenchymal–epithelial transition factor reducing gastric cancer cell growth
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Chemical Research"
DOI: 10.1177/1747519819898354
Abstract: Anti-gastric cancer activity of 18 synthesized compounds was studied using theoretical and computational method. The studied compounds were docked against mesenchymal–epithelial transition factor (PDB ID: 2wgj) and the obtained scoring was compared with the standard… read more here.
Keywords: gastric cancer; epithelial transition; transition factor; mesenchymal epithelial ... See more keywords
The mechanisms of colorectal cancer cell mesenchymal-epithelial transition induced by hepatocyte exosome-derived miR-203a-3p
Sign Up to like & getrecommendations! Published in 2021 at "BMC Cancer"
DOI: 10.1186/s12885-021-08419-x
Abstract: Background Liver metastasis is the most common cause of death in patients with colorectal cancer (CRC). Phosphatase of regenerating liver-3 induces CRC metastasis by epithelial-to-mesenchymal transition, which promotes CRC cell liver metastasis. Mesenchymal-to-epithelial transition (MET),… read more here.
Keywords: epithelial transition; mir 203a; colorectal cancer; mesenchymal epithelial ... See more keywords