ALK‐rearranged Mesenchymal Neoplasms: A Report of 9 cases Further Expanding the Clinicopathologic Spectrum of Emerging Kinase Fusion Positive Group of Tumors
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DOI: 10.1002/gcc.23097
Abstract: Anaplastic lymphoma kinase (ALK) fusions are oncogenic drivers in diverse cancer types. Although well established in inflammatory myofibroblastic tumor (IMT) and epithelioid fibrous histiocytoma (EFH), ALK rearrangements also occur in the emerging family of kinase… read more here.
Keywords: rearranged mesenchymal; mesenchymal neoplasms; alk rearranged; fusion positive ... See more keywords
Expanding the spectrum of GLI1‐altered mesenchymal tumors—A high‐grade uterine sarcoma harboring a novel PAMR1::GLI1 fusion and literature review of GLI1‐altered mesenchymal neoplasms of the gynecologic tract
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DOI: 10.1002/gcc.23099
Abstract: GLI1‐altered mesenchymal tumors comprise a group of seemingly unrelated entities, including pericytoma with t(7;12) translocation, plexiform fibromyxoma, gastroblastoma, malignant epithelioid neoplasm with GLI1 rearrangements, and GLI1‐amplified mesenchymal neoplasms. Herein, we report a high‐grade uterine sarcoma… read more here.
Keywords: fusion; mesenchymal neoplasms; sarcoma; gli1 altered ... See more keywords
Gene fusions in superficial mesenchymal neoplasms: Emerging entities and useful diagnostic adjuncts.
Sign Up to like & getrecommendations! Published in 2023 at "Seminars in diagnostic pathology"
DOI: 10.1053/j.semdp.2023.04.014
Abstract: Cutaneous mesenchymal neoplasms are diagnostically challenging because of their overlapping morphology, and, often, the limited tissue in skin biopsy specimens. Molecular and cytogenetic techniques have identified characteristic gene fusions in many of these tumor types,… read more here.
Keywords: cell; mesenchymal neoplasms; gene fusions; tumor ... See more keywords
Nevus, melanoma, or something else? Mesenchymal neoplasms with melanocytic differentiation
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DOI: 10.1111/cup.14232
Abstract: The overwhelming majority of cutaneous neoplasms with melanocytic differentiation are nevi, melanomas, or less commonly melanocytomas. Nevertheless, there is also a group of mesenchymal neoplasms with genuine melanocytic differentiation which can create diagnostic difficulties with… read more here.
Keywords: mesenchymal neoplasms; melanoma something; nevus melanoma; melanocytic differentiation ... See more keywords
Recent advances in the diagnosis, classification and molecular pathogenesis of cutaneous mesenchymal neoplasms
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DOI: 10.1111/his.14450
Abstract: The diagnosis of cutaneous mesenchymal neoplasms remains challenging, due to a combination of overlapping histological features, the rarity of some diagnoses and often inadequate sampling in superficial biopsies. Here, we describe recent advances in cutaneous… read more here.
Keywords: histopathology; molecular pathogenesis; diagnosis; recent advances ... See more keywords
Histologic characterization of paediatric mesenchymal neoplasms treated with kinase‐targeted therapy
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DOI: 10.1111/his.14680
Abstract: Recurrent alterations involving receptor tyrosine or cytoplasmic kinase genes have been described in soft‐tissue neoplasms such as infantile fibrosarcoma (IFS) and inflammatory myofibroblastic tumour (IMT). Recent trials and regulatory approvals for targeted inhibitors against the… read more here.
Keywords: mesenchymal neoplasms; characterization paediatric; neoplasms treated; histologic characterization ... See more keywords
Utility of Retrospective Molecular Analysis in Diagnostically Challenging Mesenchymal Neoplasms.
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DOI: 10.1177/10668969231157783
Abstract: Introduction: Molecular analysis plays a growing role in the diagnosis of mesenchymal neoplasms. The aim of this study was to retrospectively apply broad, multiplex molecular assays (a solid tumor targeted next-generation sequencing [NGS]) assay and… read more here.
Keywords: diagnostically challenging; mesenchymal neoplasms; molecular analysis; challenging mesenchymal ... See more keywords