Scale‐Up of Human Amniotic Epithelial Cells Through Regulation of Epithelial‐Mesenchymal Plasticity Under Defined Conditions (Adv. Sci. 11/2025)
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DOI: 10.1002/advs.202570071
Abstract: Human Amniotic Epithelial Cells Human amniotic epithelial cells (hAECs) originate from the amniotic ectoderm. The proliferation of hAECs during the embryonic development is related to their epithelial mesenchymal plasticity (EMP) properties, which is lost in… read more here.
Keywords: mesenchymal plasticity; amniotic epithelial; epithelial mesenchymal; human amniotic ... See more keywords
Dynamics of Epithelial–Mesenchymal Plasticity: What Have Single-Cell Investigations Elucidated So Far?
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DOI: 10.1021/acsomega.2c07989
Abstract: Epithelial–mesenchymal plasticity (EMP) is a key driver of cancer metastasis and therapeutic resistance, through which cancer cells can reversibly and dynamically alter their molecular and functional traits along the epithelial–mesenchymal spectrum. While cells in the… read more here.
Keywords: cell; mesenchymal plasticity; single cell; epithelial mesenchymal ... See more keywords
Prostate cancer: Enzalutamide promotes mesenchymal plasticity via Snail activation
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DOI: 10.1038/nrurol.2017.55
Abstract: androgen receptor signaling induces Snailmediated epithelial-mesenchymal plasticity in prostate cancer. Cancer Res. http://dx.doi.org/ 10.1158/0008-5472.CAN-16-2169 (2017) Snail was the only consistently upregulated EMP driver at both the mRNA and protein levels P. M oran/M cm ilan… read more here.
Keywords: cancer; snail; mesenchymal plasticity; prostate cancer ... See more keywords
Tropomyosin1 isoforms underlie epithelial to mesenchymal plasticity, metastatic dissemination, and resistance to chemotherapy in high-grade serous ovarian cancer
Sign Up to like & getrecommendations! Published in 2024 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-024-01267-9
Abstract: Phenotypic plasticity, defined as the ability of individual cells with stable genotypes to exert different phenotypes upon exposure to specific environmental cues, represent the quintessential hallmark of the cancer cell en route from the primary… read more here.
Keywords: cancer; high grade; mesenchymal plasticity; ovarian cancer ... See more keywords
Cellular geometry and epithelial-mesenchymal plasticity intersect with PIEZO1 in breast cancer cells
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DOI: 10.1038/s42003-024-06163-z
Abstract: Differences in shape can be a distinguishing feature between different cell types, but the shape of a cell can also be dynamic. Changes in cell shape are critical when cancer cells escape from the primary… read more here.
Keywords: cancer; cancer cells; mesenchymal plasticity; geometry ... See more keywords
Epithelial-Mesenchymal Plasticity and Endothelial-Mesenchymal Transition in Cutaneous Wound Healing.
Sign Up to like & getrecommendations! Published in 2022 at "Cold Spring Harbor perspectives in biology"
DOI: 10.1101/cshperspect.a041237
Abstract: Epithelial and endothelial cells possess the inherent plasticity to undergo morphological, cellular, and molecular changes leading to their resemblance of mesenchymal cells. A prevailing notion has been that cutaneous wound reepithelialization involves partial epithelial-to-mesenchymal transition… read more here.
Keywords: wound; mesenchymal transition; plasticity; mesenchymal plasticity ... See more keywords
Mesenchymal plasticity of devil facial tumour cells during in vivo vaccine and immunotherapy trials
Sign Up to like & getrecommendations! Published in 2021 at "Immunology and Cell Biology"
DOI: 10.1111/imcb.12451
Abstract: Immune evasion is critical to the growth and survival of cancer cells. This is especially pertinent to transmissible cancers, which evade immune detection across genetically diverse hosts. The Tasmanian devil (Sarcophilus harrisii) is threatened by… read more here.
Keywords: immune evasion; devil facial; tumour; dft1 ... See more keywords
Cooperative pro-tumorigenic adaptation to oncogenic RAS through epithelial-to-mesenchymal plasticity
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DOI: 10.1126/sciadv.adi1736
Abstract: In breast cancers, aberrant activation of the RAS/MAPK pathway is strongly associated with mesenchymal features and stemness traits, suggesting an interplay between this mitogenic signaling pathway and epithelial-to-mesenchymal plasticity (EMP). By using inducible models of… read more here.
Keywords: tumorigenic adaptation; mesenchymal plasticity; epithelial mesenchymal; cooperative pro ... See more keywords
Epithelial-mesenchymal plasticity in tumor immune evasion.
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DOI: 10.1158/0008-5472.can-21-4370
Abstract: Epithelial-mesenchymal transition (EMT) is a fundamental process that occurs during embryogenesis and tissue repair. However, EMT can be hijacked by malignant cells, where it may promote immune evasion and metastasis. Classically considered a dichotomous transition,… read more here.
Keywords: epithelial mesenchymal; mesenchymal plasticity; plasticity tumor; immune evasion ... See more keywords
Abstract 2675: Tumor clones display intrinsic and stable rates of progression and coordination of the tumor microenvironment in association with epithelial mesenchymal plasticity
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DOI: 10.1158/1538-7445.am2025-2675
Abstract: Delayed relapse is attributable to residual tumor cells that remain minimally proliferative/quiescent until favorable conditions for growth are met, but what determines the overall duration of remission is unresolved. Recent evidence suggests that epithelial-mesenchymal plasticity… read more here.
Keywords: tumor microenvironment; tumor clones; mesenchymal plasticity; culture ... See more keywords
The crosstalk between lncRNA and microRNA in cancer metastasis: orchestrating the epithelial-mesenchymal plasticity
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DOI: 10.18632/oncotarget.13957
Abstract: Noncoding RNAs (ncRNAs) have been demonstrated to closely associate with gene regulation and encompass the well-known microRNAs (miRNAs), as well as the most recently acknowledged long noncoding RNAs (lncRNAs). Current evidence indicates that lncRNAs can… read more here.
Keywords: mesenchymal plasticity; cancer metastasis; epithelial mesenchymal; crosstalk ... See more keywords