Dynamics of Epithelial–Mesenchymal Plasticity: What Have Single-Cell Investigations Elucidated So Far?
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.2c07989
Abstract: Epithelial–mesenchymal plasticity (EMP) is a key driver of cancer metastasis and therapeutic resistance, through which cancer cells can reversibly and dynamically alter their molecular and functional traits along the epithelial–mesenchymal spectrum. While cells in the… read more here.
Keywords: cell; mesenchymal plasticity; single cell; epithelial mesenchymal ... See more keywords
Prostate cancer: Enzalutamide promotes mesenchymal plasticity via Snail activation
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Urology"
DOI: 10.1038/nrurol.2017.55
Abstract: androgen receptor signaling induces Snailmediated epithelial-mesenchymal plasticity in prostate cancer. Cancer Res. http://dx.doi.org/ 10.1158/0008-5472.CAN-16-2169 (2017) Snail was the only consistently upregulated EMP driver at both the mRNA and protein levels P. M oran/M cm ilan… read more here.
Keywords: cancer; snail; mesenchymal plasticity; prostate cancer ... See more keywords
Epithelial-Mesenchymal Plasticity and Endothelial-Mesenchymal Transition in Cutaneous Wound Healing.
Sign Up to like & getrecommendations! Published in 2022 at "Cold Spring Harbor perspectives in biology"
DOI: 10.1101/cshperspect.a041237
Abstract: Epithelial and endothelial cells possess the inherent plasticity to undergo morphological, cellular, and molecular changes leading to their resemblance of mesenchymal cells. A prevailing notion has been that cutaneous wound reepithelialization involves partial epithelial-to-mesenchymal transition… read more here.
Keywords: wound; mesenchymal transition; plasticity; mesenchymal plasticity ... See more keywords
Mesenchymal plasticity of devil facial tumour cells during in vivo vaccine and immunotherapy trials
Sign Up to like & getrecommendations! Published in 2021 at "Immunology and Cell Biology"
DOI: 10.1111/imcb.12451
Abstract: Immune evasion is critical to the growth and survival of cancer cells. This is especially pertinent to transmissible cancers, which evade immune detection across genetically diverse hosts. The Tasmanian devil (Sarcophilus harrisii) is threatened by… read more here.
Keywords: immune evasion; devil facial; tumour; dft1 ... See more keywords
Epithelial-mesenchymal plasticity in tumor immune evasion.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-21-4370
Abstract: Epithelial-mesenchymal transition (EMT) is a fundamental process that occurs during embryogenesis and tissue repair. However, EMT can be hijacked by malignant cells, where it may promote immune evasion and metastasis. Classically considered a dichotomous transition,… read more here.
Keywords: epithelial mesenchymal; mesenchymal plasticity; plasticity tumor; immune evasion ... See more keywords
The crosstalk between lncRNA and microRNA in cancer metastasis: orchestrating the epithelial-mesenchymal plasticity
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.13957
Abstract: Noncoding RNAs (ncRNAs) have been demonstrated to closely associate with gene regulation and encompass the well-known microRNAs (miRNAs), as well as the most recently acknowledged long noncoding RNAs (lncRNAs). Current evidence indicates that lncRNAs can… read more here.
Keywords: mesenchymal plasticity; cancer metastasis; epithelial mesenchymal; crosstalk ... See more keywords
Metabolic Reprogramming and Epithelial-Mesenchymal Plasticity: Opportunities and Challenges for Cancer Therapy
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.00792
Abstract: Metabolic reprogramming and epithelial-mesenchymal plasticity are both hallmarks of the adaptation of cancer cells for tumor growth and progression. For metabolic changes, cancer cells alter metabolism by utilizing glucose, lipids, and amino acids to meet… read more here.
Keywords: metabolic reprogramming; reprogramming epithelial; mesenchymal plasticity; epithelial mesenchymal ... See more keywords
Orchestration of mesenchymal plasticity and immune evasiveness via rewiring of the metabolic program in pancreatic ductal adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1005566
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is the most fatal cancer in humans, due to its difficulty of early detection and its high metastatic ability. The occurrence of epithelial to mesenchymal transition in preinvasive pancreatic lesions has… read more here.
Keywords: mesenchymal plasticity; pancreatic ductal; pdac; ductal adenocarcinoma ... See more keywords
Emerging Role of CREB in Epithelial to Mesenchymal Plasticity of Pancreatic Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.925687
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive solid malignancy with a high rate of metastasis and therapeutic resistance as its major hallmarks. Although a defining mutational event in pancreatic cancer initiation is the presence of… read more here.
Keywords: cancer; pancreatic cancer; mesenchymal plasticity; epithelial mesenchymal ... See more keywords