Effect of Intramyocardial Grafting Collagen Scaffold With Mesenchymal Stromal Cells in Patients With Chronic Ischemic Heart Disease
Sign Up to like & getrecommendations! Published in 2020 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2020.16236
Abstract: This randomized clinical trial evaluates the safety and feasibility of a collagen gel vehicle for mesenchymal stromal cell treatment, compared with cell treatment alone and no cell treatment, in patients with chronic ischemic heart disease… read more here.
Keywords: collagen; mesenchymal stromal; heart disease; chronic ischemic ... See more keywords
A Novel Synthetic, Xeno‐Free Biomimetic Surface for Serum‐Free Expansion of Human Mesenchymal Stromal Cells
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Biosystems"
DOI: 10.1002/adbi.202000008
Abstract: Human mesenchymal stromal cells (hMSCs) have enormous potential for the treatment of various inflammatory and degenerative diseases. Their manufacturing for cell‐based therapies requires extensive ex vivo expansion and optimal growth conditions. To support cell adhesion,… read more here.
Keywords: human mesenchymal; mesenchymal stromal; expansion; stromal cells ... See more keywords
High-throughput on-chip human mesenchymal stromal cell potency prediction.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202101995
Abstract: Human mesenchymal stromal cells (hMSCs) are a promising source for regenerative cell therapy. However, hMSC clinical use has been stymied by product variability across hMSC donors and manufacturing practices resulting in inconsistent clinical outcomes. The… read more here.
Keywords: mesenchymal stromal; human mesenchymal; potency; high throughput ... See more keywords
Acute Myeloid Leukemia Cells Educate Mesenchymal Stromal Cells toward an Adipogenic Differentiation Propensity with Leukemia Promotion Capabilities
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DOI: 10.1002/advs.202105811
Abstract: Mesenchymal stromal cells (MSCs) are essential elements of the bone marrow (BM) microenvironment, which have been widely implicated in pathways that contribute to leukemia growth and resistance. Recent reports showed genotypic and phenotypic alterations in… read more here.
Keywords: myeloid leukemia; mesenchymal stromal; leukemia; acute myeloid ... See more keywords
Scalable Manufacturing of Human Mesenchymal Stromal Cells in the Vertical-Wheel Bioreactor System: An Experimental and Economic Approach.
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology journal"
DOI: 10.1002/biot.201800716
Abstract: Mesenchymal stromal cells (MSC) hold great promise for tissue engineering applications and cell-based therapies. Large cell doses (>1 × 106 cells kg-1 ) and Good Manufacturing Practices (GMP)-compliant processes are however required for clinical purposes.… read more here.
Keywords: mesenchymal stromal; system; vertical wheel; manufacturing ... See more keywords
Dimethyloxalylglycine, a small molecule, synergistically increases the homing and angiogenic properties of human mesenchymal stromal cells when cultured as 3D spheroids
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology Journal"
DOI: 10.1002/biot.202000389
Abstract: Strategies aiming at increasing the survival and paracrine activity of human mesenchymal stromal cells (MSCs) are of utmost importance to achieve the full therapeutic potential of these cells. Herein, we propose both physical and biochemical… read more here.
Keywords: human mesenchymal; mesenchymal stromal; cells cultured; small molecule ... See more keywords
Umbilical cord derived mesenchymal stromal cells in microcarrier based industrial scale culture sustain the immune regulatory functions
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology Journal"
DOI: 10.1002/biot.202000558
Abstract: Mesenchymal stromal cells (MSCs) have been isolated from numerous sources and are potentially therapeutic against various diseases. Umbilical cord‐derived MSCs (UC‐MSCs) are considered superior to other tissue‐derived MSCs since they have a higher proliferation rate… read more here.
Keywords: mesenchymal stromal; stromal cells; microcarrier based; mscs ... See more keywords
A comparative evaluation of layer‐by‐layer assembly techniques for surface modification of microcarriers used in human mesenchymal stromal cell manufacturing
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Journal"
DOI: 10.1002/biot.202100605
Abstract: The demand for large quantities of highly potent human mesenchymal stromal cells (hMSCs) is growing given their therapeutic potential. To meet high production needs, suspension‐based cell cultures using microcarriers are commonly used. Microcarriers are commonly… read more here.
Keywords: cell; mesenchymal stromal; layer; human mesenchymal ... See more keywords
Multiomics characterization of mesenchymal stromal cells cultured in monolayer and as aggregates
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27317
Abstract: Mesenchymal stromal cells (MSCs) have failed to consistently demonstrate their therapeutic efficacy in clinical trials, due in part to variability in culture conditions used for their production. Of various culture conditions used for MSC production,… read more here.
Keywords: mesenchymal stromal; monolayer; physiology; culture conditions ... See more keywords
Enhanced bioprocess control to advance the manufacture of mesenchymal stromal cell-derived extracellular vesicles in stirred-tank bioreactors.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.28378
Abstract: Extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) act as signalling mediators of cellular responses. However, despite representing a promising alternative to cell-based therapies, clinical translation of EVs is currently limited by their lack… read more here.
Keywords: cell; extracellular vesicles; mesenchymal stromal; manufacture ... See more keywords
PRESERVATION OF CRITICAL QUALITY ATTRIBUTES OF MESENCHYMAL STROMAL CELLS IN 3D BIOPRINTED STRUCTURES BY USING NATURAL HYDROGEL SCAFFOLDS.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.28381
Abstract: 3D bioprinting is an emerging technology that enables complex spatial modelling of cell-based tissue engineering products, whose therapeutic potential in regenerative medicine is enormous. However, its success largely depends on the definition of a bioprintable… read more here.
Keywords: quality attributes; mesenchymal stromal; using natural; natural hydrogel ... See more keywords