Vasorelaxation elicited by endogenous and exogenous hydrogen sulfide in mouse mesenteric arteries
Sign Up to like & getrecommendations! Published in 2019 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-019-01752-w
Abstract: H 2 S causes vasorelaxation however there is considerable heterogeneity in the reported pharmacological mechanism of this effect. This study examines the contribution of endogenously released H 2 S in the regulation of vascular tone… read more here.
Keywords: vasorelaxation elicited; mouse mesenteric; elicited endogenous; vasorelaxation ... See more keywords
Crohn's Disease Complicated With Extensive Thrombosis of Limbs and Mesenteric Arteries: A Case Report and Literature Review.
Sign Up to like & getrecommendations! Published in 2019 at "Annals of vascular surgery"
DOI: 10.1016/j.avsg.2018.12.079
Abstract: BACKGROUND Crohn's disease (CD) is a lifelong disease characterized by purulent inflammation in the gastrointestinal tract from any part of the mouth to the anus. Various studies have reported complications of the CD. However, arterial… read more here.
Keywords: extensive thrombosis; disease; mesenteric arteries; thrombosis ... See more keywords
SKA‐31, an activator of endothelial Ca2+‐activated K+ channels evokes robust vasodilation in rat mesenteric arteries
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.05.006
Abstract: Abstract It is now well recognized that endothelial KCa2.3 and KCa3.1 channel activities contribute to dilation of resistance arteries via endothelium‐mediated hyperpolarization and vascular smooth muscle relaxation. In this study, we have investigated the functional… read more here.
Keywords: kca2 kca3; vasodilation; mesenteric arteries; channel ... See more keywords
Resistance mesenteric arteries display hypercontractility in the resolution time of Strongyloides venezuelensis infection.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental parasitology"
DOI: 10.1016/j.exppara.2021.108078
Abstract: The blood flow in the mesenteric region is crucial for nutrient absorption and immune response in the gastrointestinal tract. The presence of nematodes or their excreted/secreted products seems to provoke vascular dysfunction. However, it is… read more here.
Keywords: hypercontractility; venezuelensis infection; infection; mesenteric arteries ... See more keywords
Activation of Cav1.2 and BKCa is involved in the downregulation of caffeine-induced contraction in mice mesenteric arteries.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.116555
Abstract: AIMS Caffeine is a methylxanthine with multiple actions in vascular smooth muscle cells (VSMCs), including the increase in the intracellular Ca2+ (iCa2+) concentration by the activation of ryanodine receptors (RyRs). The present study aimed at… read more here.
Keywords: caffeine; bkca; mesenteric arteries; contraction ... See more keywords
Equilin displays similar endothelium-independent vasodilator potential to 17β-estradiol regardless of lower potential to inhibit calcium entry
Sign Up to like & getrecommendations! Published in 2019 at "Steroids"
DOI: 10.1016/j.steroids.2018.11.006
Abstract: &NA; Conjugated equine estrogens (CEE) have been widely used by women who seek to relieve symptoms of menopause. Despite evidence describing protective effects against risk factors for cardiovascular diseases by naturally occurring estrogens, little is… read more here.
Keywords: relaxation; estradiol; bgr estradiol; equilin ... See more keywords
Epigenetic regulation of L-type voltage-gated Ca2+ channels in mesenteric arteries of aging hypertensive rats
Sign Up to like & getrecommendations! Published in 2017 at "Hypertension Research"
DOI: 10.1038/hr.2016.167
Abstract: Accumulating evidence has shown that epigenetic regulation is involved in hypertension and aging. L-type voltage-gated Ca2+ channels (LTCCs), the dominant channels in vascular myocytes, greatly contribute to arteriole contraction and blood pressure (BP) control. We… read more here.
Keywords: mir 328; hypertensive rats; mesenteric arteries; expression ... See more keywords
Neflamapimod induces vasodilation in resistance mesenteric arteries by inhibiting p38 MAPKα and downstream Hsp27 phosphorylation
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-08877-8
Abstract: Neflamapimod, a selective inhibitor of p38 mitogen activated protein kinase alpha (MAPKα), is under clinical investigation for its efficacy in Alzheimer’s disease (AD) and dementia with Lewy Bodies (DLB). Here, we investigated if neflamapimod-mediated acute… read more here.
Keywords: mapk; mesenteric arteries; phosphorylation; p38 mapk ... See more keywords
Vasodilatory effects of cannabidiol in human pulmonary and rat small mesenteric arteries: modification by hypertension and the potential pharmacological opportunities
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Hypertension"
DOI: 10.1097/hjh.0000000000002333
Abstract: Objective: Cannabidiol (CBD) has been suggested as a potential antihypertensive drug. The aim of our study was to investigate its vasodilatory effect in isolated human pulmonary arteries (hPAs) and rat small mesenteric arteries (sMAs). Methods:… read more here.
Keywords: rat small; human pulmonary; hypertension; mesenteric arteries ... See more keywords
Chronic exercise mediates epigenetic suppression of L-type Ca2+ channel and BKCa channel in mesenteric arteries of hypertensive rats.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Hypertension"
DOI: 10.1097/hjh.0000000000002457
Abstract: BACKGROUND Regular exercise is a lifestyle intervention for controlling hypertension and has an improving effect on vascular function. Voltage-gated L-type Ca (LTCC) and large-conductance Ca-activated K (BKCa) channels are two principal mediators of vascular smooth… read more here.
Keywords: hypertension; mesenteric arteries; bkca channel; exercise ... See more keywords
Adiponectin improves endothelial function in mesenteric arteries of rats fed a high‐fat diet: role of perivascular adipose tissue
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Pharmacology"
DOI: 10.1111/bph.13756
Abstract: Adiponectin, the most abundant peptide secreted by adipocytes, is involved in the regulation of energy metabolism and vascular physiology. Here, we have investigated the effects of exogenous administration of adiponectin on metabolism, vascular reactivity and… read more here.
Keywords: perivascular adipose; mesenteric arteries; fed high; high fat ... See more keywords