LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "meshwork cells" as a keyword



Impact of pigment dispersion on trabecular meshwork cells

Sign Up to like & get
recommendations! Published in 2019 at "Graefe's Archive for Clinical and Experimental Ophthalmology"

DOI: 10.1007/s00417-019-04300-7

Abstract: PurposeDysfunction of the trabecular meshwork (TM) in pigmentary glaucoma contributes to increased aqueous humor outflow resistance and intraocular pressure. In this study, we investigated the effect of pigment dispersion on trabecular meshwork cells.MethodsPorcine TM cells… read more here.

Keywords: meshwork cells; trabecular meshwork; dispersion trabecular; dispersion ... See more keywords

1α,25-dihydroxyvitamin D3 attenuates oxidative stress-induced damage in human trabecular meshwork cells by inhibiting TGFβ-SMAD3-VDR pathway.

Sign Up to like & get
recommendations! Published in 2019 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2019.06.027

Abstract: Evidence indicates that 1α, 25-dihydroxy vitamin D3 (1, 25-(OH)2D3) markedly reduces intraocular pressure (IOP) in nonhuman primates, while the biochemical mechanisms are unclear. To investigate the influence of oxidative stress on human trabecular meshwork cells… read more here.

Keywords: meshwork cells; trabecular meshwork; human trabecular; stress ... See more keywords

Interaction of cochlin and mechanosensitive channel TREK-1 in trabecular meshwork cells influences the regulation of intraocular pressure

Sign Up to like & get
recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-00430-2

Abstract: In the eye, intraocular pressure (IOP) is tightly regulated and its persistent increase leads to ocular hypertension and glaucoma. We have previously shown that trabecular meshwork (TM) cells might detect aqueous humor fluid shear stress… read more here.

Keywords: intraocular pressure; trabecular meshwork; meshwork cells; trek ... See more keywords
Photo from wikipedia

Altered Expression of Extracellular Vesicles miRNAs from Primary Human Trabecular Meshwork Cells Induced by Transforming Growth Factor-β2.

Sign Up to like & get
recommendations! Published in 2021 at "DNA and cell biology"

DOI: 10.1089/dna.2020.6298

Abstract: Primary open-angle glaucoma (POAG) is tightly related with extracellular matrix (ECM) remodeling of human trabecular meshwork cells (HTMCs). Transforming growth factor-β2 (TGF-β2) can induce ECM remodeling. The aim of the study was to investigate the… read more here.

Keywords: meshwork cells; trabecular meshwork; transforming growth; human trabecular ... See more keywords
Photo by nci from unsplash

Trabecular meshwork cells are a valuable resource for cellular therapy of glaucoma

Sign Up to like & get
recommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"

DOI: 10.1111/jcmm.14158

Abstract: Trabecular meshwork (TM) contains a subset of adult stem cells or progenitors that can be differentiated into corneal endothelial cells, adipocytes and chondrocytes, but not osteocytes or keratocytes. Accordingly, these progenitors can be utilized as… read more here.

Keywords: meshwork cells; trabecular meshwork; valuable resource; meshwork ... See more keywords

Inhibition of Rho Kinase Induces Antioxidative Molecules and Suppresses Reactive Oxidative Species in Trabecular Meshwork Cells

Sign Up to like & get
recommendations! Published in 2017 at "Journal of Ophthalmology"

DOI: 10.1155/2017/7598140

Abstract: Purpose To investigate the effect of rho kinase inhibitors on oxidative stress in trabecular meshwork (TM) cells. Methods TM cells were isolated from the eyes of cynomolgus monkeys. Y-27632 and menadione were used to inhibit… read more here.

Keywords: meshwork cells; trabecular meshwork; ontology; kinase ... See more keywords

The effects of losartan on cytomegalovirus infection in human trabecular meshwork cells

Sign Up to like & get
recommendations! Published in 2019 at "PLoS ONE"

DOI: 10.1371/journal.pone.0218471

Abstract: Background Human cytomegalovirus (CMV) has been emerged as one of the causes of acute recurrent or chronic hypertensive anterior uveitis in immunocompetent. In hypertensive anterior uveitis, human trabecular meshwork (TM) cells are considered a focus… read more here.

Keywords: meshwork cells; effects losartan; trabecular meshwork; infection human ... See more keywords

Influence of Anti-Glaucoma Drugs on Uptake of Extracellular Vesicles by Trabecular Meshwork Cells

Sign Up to like & get
recommendations! Published in 2021 at "International Journal of Nanomedicine"

DOI: 10.2147/ijn.s283164

Abstract: Background Extracellular vesicles (EVs) are capable of manipulating cellular functions for the maintenance of biological homeostasis and disease progression, such as in glaucoma disease. These nano-particles carry a net negative surface charge under physiological conditions… read more here.

Keywords: glaucoma; anti glaucoma; glaucoma drugs; extracellular vesicles ... See more keywords

Cell senescence alters responses of porcine trabecular meshwork cells to shear stress

Sign Up to like & get
recommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2022.1083130

Abstract: Mechanical microenvironment and cellular senescence of trabecular meshwork cells (TMCs) are suspected to play a vital role in primary open-angle glaucoma pathogenesis. However, central questions remain about the effect of shear stress on TMCs and… read more here.

Keywords: stress; meshwork cells; senescence; trabecular meshwork ... See more keywords

Myocilin Gene Mutation Induced Autophagy Activation Causes Dysfunction of Trabecular Meshwork Cells

Sign Up to like & get
recommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2022.900777

Abstract: Trabecular meshwork dysfunction is the main cause of primary open angle glaucoma (POAG) associated with elevated intraocular pressure (IOP). Mutant myocilin causes glaucoma mainly via elevating IOP. Previously we have found that accumulated Asn 450… read more here.

Keywords: meshwork cells; mutant myocilin; trabecular meshwork; myocilin ... See more keywords

miR-17-5p regulates the proliferation and apoptosis of human trabecular meshwork cells by targeting phosphatase and tensin homolog

Sign Up to like & get
recommendations! Published in 2019 at "Molecular Medicine Reports"

DOI: 10.3892/mmr.2019.9973

Abstract: Glaucoma is one of the leading causes of blindness. Previous studies have indicated that the oxidative stress-induced apoptosis of trabecular meshwork cells (TMCs) may serve a key role in the pathogenesis of glaucoma, and that… read more here.

Keywords: meshwork cells; trabecular meshwork; apoptosis; proliferation apoptosis ... See more keywords