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Published in 2018 at "Annals of Neurology"
DOI: 10.1002/ana.25180
Abstract: To evaluate the outcomes 1 year and longer following stereotactic laser amygdalohippocampotomy for mesial temporal lobe epilepsy in a large series of patients treated over a 5‐year period since introduction of this novel technique. read more here.
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Published in 2022 at "Annals of Neurology"
DOI: 10.1002/ana.26581
Abstract: Genetic factors have long been debated as a cause of failure of surgery for mesial temporal lobe epilepsy (MTLE). We investigated whether rare genetic variation influences seizure outcomes of MTLE surgery. read more here.
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Published in 2020 at "Brain and Behavior"
DOI: 10.1002/brb3.1820
Abstract: Ictal head version is a common clinical manifestation of mesial temporal lobe epilepsy (MTLE). Nevertheless, the location of the symptomatogenic zone and the network involved in head version remains unclear. We attempt to explain these… read more here.
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Published in 2021 at "Human Brain Mapping"
DOI: 10.1002/hbm.25418
Abstract: It is now widely accepted that seizures arise from the coordinated activity of epileptic networks, and as a result, traditional methods of analyzing seizures have been augmented by techniques like single‐pulse electrical stimulation (SPES) that… read more here.
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Published in 2020 at "Molecular Neurobiology"
DOI: 10.1007/s12035-020-01993-4
Abstract: The aim of this study is to investigate the mitochondrial dysfunction and pathogenic role of the mitochondrial genome in the progression of mesial temporal lobe epilepsy (MTLE) in vivo and in vitro. Mitochondrial DNA (mtDNA)… read more here.
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Published in 2017 at "Neuroscience Bulletin"
DOI: 10.1007/s12264-017-0186-2
Abstract: In the present study we explored the different patterns of volumetric atrophy in hippocampal subregions of patients with left and right mesial temporal lobe epilepsy with hippocampal sclerosis (TLE-HS). Meanwhile, the memory impairment patterns in… read more here.
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Published in 2021 at "Brain Research"
DOI: 10.1016/j.brainres.2020.147230
Abstract: Inflammation plays a role in the pathophysiology of mesial temporal lobe epilepsy (MTLE). Inflammasome pathways, including the NLRP1 and NLRP3-induced ones, promote neuroinflammation and pyroptosis through interleukin (IL)-1β and caspase-1 action. Evaluation of NLRP1 in… read more here.
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Published in 2021 at "Epilepsy Research"
DOI: 10.1016/j.eplepsyres.2021.106562
Abstract: BACKGROUND Mesial temporal sclerosis (MTS) is the most common cause of temporal lobe epilepsy (TLE). While MTS is associated with a high cure rate after temporal lobectomy (TL), postoperative neurocognitive deficits are common, and a… read more here.
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Published in 2020 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2020.02.024
Abstract: Mesial temporal lobe epilepsy with hippocampal sclerosis is the most frequent form of focal epilepsy in adults, and it is often refractory to drug treatment. Regardless of the efforts on developing new antiepileptic drugs for… read more here.
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Published in 2017 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2017.07.008
Abstract: Low-voltage fast (LVF) and hypersynchronous (HYP) - onset seizures occur in the EEG obtained with depth electrodes from mesial temporal lobe epilepsy (MTLE) patients and animal models. In epileptic rats analyzed up to approximately two… read more here.
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Published in 2020 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2019.12.002
Abstract: Mesial temporal lobe (MTL) is prominently affected in normal aging and associated with neurodegeneration in AD. Whether or not MTL atrophy is dependent on increasing amyloid load before the emergence of cognitive deficits is still… read more here.