Rare Genetic Variants in Human APC Are Implicated in Mesiodens and Isolated Supernumerary Teeth
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DOI: 10.3390/ijms24054255
Abstract: The activation of Wnt/β-catenin signalling is a prerequisite for odontogenesis. APC, a member of the AXIN-CK1-GSK3β-APC β-catenin destruction complex, functions to modulate Wnt/β-catenin signalling to establish regular teeth number and positions. APC loss-of-function mutations are… read more here.
Keywords: supernumerary teeth; mesiodens isolated; genetic variants; wnt catenin ... See more keywords