Enantioselective Syntheses of 2-Azabicyclo[2.2.1]heptanes via Brønsted Acid Catalyzed Ring-Opening of meso-Epoxides.
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DOI: 10.1021/acs.orglett.2c03529
Abstract: A chiral phosphoric acid-catalyzed ring-opening of meso-epoxides was developed. A range of 2-azabicyclo[2.2.1]heptanes were obtained in high yields with excellent enantioselectivities. In addition, the hydroxyl and amide groups in the products provided handles for further… read more here.
Keywords: opening meso; catalyzed ring; meso epoxides; azabicyclo heptanes ... See more keywords
Biocatalytic Asymmetric Ring-Opening of meso-Epoxides to Enantiopure Cyclic trans-β-Amino Alcohols Involving a Key Amine Transaminase
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DOI: 10.1039/d4gc00827h
Abstract: Chiral cyclic β-amino alcohols are vital building blocks for the synthesis of numerous pharmaceuticals and bioactive molecules. Asymmetric ring-opening of cyclic meso-epoxides is a straightforward and appealing method for their... read more here.
Keywords: biocatalytic asymmetric; asymmetric ring; amino alcohols; ring opening ... See more keywords