miR‐15a‐5p suppresses inflammation and fibrosis of peritoneal mesothelial cells induced by peritoneal dialysis via targeting VEGFA
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27660
Abstract: Long‐term peritoneal dialysis (PD) often ends up with ultrafiltration failure (UFF) which is partially caused by persistent inflammation and fibrosis of peritoneal tissues. However, the mechanism is still unclear. In the current study, the peritoneum… read more here.
Keywords: inflammation fibrosis; fibrosis peritoneal; mir 15a; mesothelial cells ... See more keywords
TAZ/WWTR1 mediates liver mesothelial–mesenchymal transition induced by stiff extracellular environment, TGF‐β1, and lysophosphatidic acid
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30750
Abstract: Mesothelial cells cover the surface of the internal organs and the walls of body cavities, facilitating the movement between organs by secretion of a lubricating fluid. Upon injury, mesothelial cells undergo a mesothelial–mesenchymal transition (MMT)… read more here.
Keywords: taz; mesenchymal transition; mesothelial mesenchymal; mesothelial cells ... See more keywords
Role of IGF-1R in epithelial–mesenchymal transdifferentiation of human peritoneal mesothelial cells
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Experimental Nephrology"
DOI: 10.1007/s10157-022-02209-w
Abstract: Peritoneal fibrosis (PF) is caused by epithelial-mesenchymal transdifferentiation (EMT) in the peritoneum under high glucose (HG) conditions. The study aimed to explored the role of Insulin-like growth factor 1 receptor (IGF-1R) in the regulation of… read more here.
Keywords: mesenchymal transdifferentiation; human peritoneal; peritoneal mesothelial; mesothelial cells ... See more keywords
AGEs induce epithelial to mesenchymal transformation of human peritoneal mesothelial cells via upregulation of STAT3
Sign Up to like & getrecommendations! Published in 2019 at "Glycoconjugate Journal"
DOI: 10.1007/s10719-019-09861-7
Abstract: Epithelial-mesenchymal transition (EMT) in peritoneum was induced during peritoneal dialysis (PD), which finally caused progressive fibrosis. However, the underlying mechanisms were not well elucidated. We established advanced glycation end-products (AGEs)-induced EMT model using primary human… read more here.
Keywords: human peritoneal; ages induce; stat3; mesothelial cells ... See more keywords
TLR2 contributes to trigger immune response of pleural mesothelial cells against Mycobacterium bovis BCG and M. tuberculosis infection
Sign Up to like & getrecommendations! Published in 2017 at "Cytokine"
DOI: 10.1016/j.cyto.2017.02.021
Abstract: HighlightsM. tuberculosis induces cytokines and chemokines production in PMCs via TLR2.M. tuberculosis activates NF‐&kgr;B and MAPKs in PMCs via TLR2 signaling.TLR2 is essential for iNOS expression in M. tuberculosis‐infected PMCs.TLR2 is critical for expression of… read more here.
Keywords: tlr2; infection; mesothelial cells; pmcs ... See more keywords
Ferroptosis-dependent extracellular vesicles from macrophage contribute to asbestos-induced mesothelial carcinogenesis through loading ferritin.
Sign Up to like & getrecommendations! Published in 2021 at "Redox biology"
DOI: 10.1016/j.redox.2021.102174
Abstract: Asbestos-associated diseases remain a social burden worldwide. Our previous studies identified asbestos-induced iron-rich milieu for mesothelial cells with ceaseless macrophage ferroptosis. However, molecular mechanisms how this mutagenic milieu influences mesothelial cells have not been elucidated… read more here.
Keywords: extracellular vesicles; asbestos induced; ferroptosis dependent; mesothelial cells ... See more keywords
Autologous peritoneal grafts permit rapid reperitonealization and prevent postoperative abdominal adhesions in an experimental rat study
Sign Up to like & getrecommendations! Published in 2017 at "Surgery"
DOI: 10.1016/j.surg.2017.05.005
Abstract: Background. Reperitonealization has attracted increasing attention for its potential to prevent postoperative abdominal adhesions and subsequent related complications. We studied the effect of an autologous peritoneal graft on reperitonealization and prevention of adhesions in a… read more here.
Keywords: reperitonealization; autologous peritoneal; mesothelial cells; abdominal adhesions ... See more keywords
MMP‐7 affects peritoneal ultrafiltration associated with elevated aquaporin‐1 expression via MAPK/ERK pathway in peritoneal mesothelial cells
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16697
Abstract: Peritoneal membrane dysfunction and the resulting ultrafiltration failure are the major disadvantages of long‐term peritoneal dialysis (PD). It becomes increasingly clear that mesothelial cells play a vital role in the pathophysiological changes of the peritoneal… read more here.
Keywords: peritoneal ultrafiltration; mmp; mesothelial cells; peritoneal mesothelial ... See more keywords
Abstract 2524: MiR-29b may suppress peritoneal metastasis via the effects on peritoneal mesothelial cells as well as on tumor cells
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-2524
Abstract: Background: Peritoneal metastasis (PM) frequently occur in patients with gastric cancer with poor prognosis. Peritoneal cavity is lined with monolayer of mesothelial cells (MC) and contains various types of cells and exosomes. MC play an… read more here.
Keywords: mir; mesothelial cells; peritoneal metastasis; mir 29b ... See more keywords
Abstract 5834: The pro-tumoral function of cancer-associated mesothelial cells
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5834
Abstract: Cancer-associated mesothelial cells have emerged as significant contributors to the tumor microenvironment, influencing tumor growth and immune evasion. Mesothelial cells are the first point of contact with ovarian cancer cells during peritoneal spread. Peritoneal mesothelial… read more here.
Keywords: ovarian cancer; mesothelial cells; cancer associated; tumor ... See more keywords
Abstract 5919: The significant role of HMGB1 in mesothelial cells in contributing to the mesothelioma development induced by asbestos
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5919
Abstract: Diffuse Malignant mesothelioma is a very aggressive cancer that is related to asbestos exposure. We found previously that following asbestos deposition in the pleura and in the peritoneum, mesothelial cells release HMGB1 that attract granulocytes… read more here.
Keywords: asbestos; mesothelial cells; hmgb1 pmeso; mesothelioma ... See more keywords