miR‐15a‐5p suppresses inflammation and fibrosis of peritoneal mesothelial cells induced by peritoneal dialysis via targeting VEGFA
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27660
Abstract: Long‐term peritoneal dialysis (PD) often ends up with ultrafiltration failure (UFF) which is partially caused by persistent inflammation and fibrosis of peritoneal tissues. However, the mechanism is still unclear. In the current study, the peritoneum… read more here.
Keywords: inflammation fibrosis; fibrosis peritoneal; mir 15a; mesothelial cells ... See more keywords
TAZ/WWTR1 mediates liver mesothelial–mesenchymal transition induced by stiff extracellular environment, TGF‐β1, and lysophosphatidic acid
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30750
Abstract: Mesothelial cells cover the surface of the internal organs and the walls of body cavities, facilitating the movement between organs by secretion of a lubricating fluid. Upon injury, mesothelial cells undergo a mesothelial–mesenchymal transition (MMT)… read more here.
Keywords: taz; mesenchymal transition; mesothelial mesenchymal; mesothelial cells ... See more keywords
Role of IGF-1R in epithelial–mesenchymal transdifferentiation of human peritoneal mesothelial cells
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Experimental Nephrology"
DOI: 10.1007/s10157-022-02209-w
Abstract: Peritoneal fibrosis (PF) is caused by epithelial-mesenchymal transdifferentiation (EMT) in the peritoneum under high glucose (HG) conditions. The study aimed to explored the role of Insulin-like growth factor 1 receptor (IGF-1R) in the regulation of… read more here.
Keywords: mesenchymal transdifferentiation; human peritoneal; peritoneal mesothelial; mesothelial cells ... See more keywords
AGEs induce epithelial to mesenchymal transformation of human peritoneal mesothelial cells via upregulation of STAT3
Sign Up to like & getrecommendations! Published in 2019 at "Glycoconjugate Journal"
DOI: 10.1007/s10719-019-09861-7
Abstract: Epithelial-mesenchymal transition (EMT) in peritoneum was induced during peritoneal dialysis (PD), which finally caused progressive fibrosis. However, the underlying mechanisms were not well elucidated. We established advanced glycation end-products (AGEs)-induced EMT model using primary human… read more here.
Keywords: human peritoneal; ages induce; stat3; mesothelial cells ... See more keywords
TLR2 contributes to trigger immune response of pleural mesothelial cells against Mycobacterium bovis BCG and M. tuberculosis infection
Sign Up to like & getrecommendations! Published in 2017 at "Cytokine"
DOI: 10.1016/j.cyto.2017.02.021
Abstract: HighlightsM. tuberculosis induces cytokines and chemokines production in PMCs via TLR2.M. tuberculosis activates NF‐&kgr;B and MAPKs in PMCs via TLR2 signaling.TLR2 is essential for iNOS expression in M. tuberculosis‐infected PMCs.TLR2 is critical for expression of… read more here.
Keywords: tlr2; infection; mesothelial cells; pmcs ... See more keywords
Ferroptosis-dependent extracellular vesicles from macrophage contribute to asbestos-induced mesothelial carcinogenesis through loading ferritin.
Sign Up to like & getrecommendations! Published in 2021 at "Redox biology"
DOI: 10.1016/j.redox.2021.102174
Abstract: Asbestos-associated diseases remain a social burden worldwide. Our previous studies identified asbestos-induced iron-rich milieu for mesothelial cells with ceaseless macrophage ferroptosis. However, molecular mechanisms how this mutagenic milieu influences mesothelial cells have not been elucidated… read more here.
Keywords: extracellular vesicles; asbestos induced; ferroptosis dependent; mesothelial cells ... See more keywords
Autologous peritoneal grafts permit rapid reperitonealization and prevent postoperative abdominal adhesions in an experimental rat study
Sign Up to like & getrecommendations! Published in 2017 at "Surgery"
DOI: 10.1016/j.surg.2017.05.005
Abstract: Background. Reperitonealization has attracted increasing attention for its potential to prevent postoperative abdominal adhesions and subsequent related complications. We studied the effect of an autologous peritoneal graft on reperitonealization and prevention of adhesions in a… read more here.
Keywords: reperitonealization; autologous peritoneal; mesothelial cells; abdominal adhesions ... See more keywords
LCZ696, an angiotensin receptor-neprilysin inhibitor, ameliorates epithelial-mesenchymal transition of peritoneal mesothelial cells and M2 macrophage polarization
Sign Up to like & getrecommendations! Published in 2024 at "Renal Failure"
DOI: 10.1080/0886022x.2024.2392849
Abstract: Abstract Aims To investigate the effects and mechanisms of LCZ696, an angiotensin receptor-neprilysin inhibitor (ARNI), on epithelial-mesenchymal transition (EMT) of peritoneal mesothelial cells and on macrophage M2 polarization. Methods We examined the effects of LCZ696… read more here.
Keywords: mesothelial cells; lcz696 angiotensin; macrophage polarization; peritoneal mesothelial ... See more keywords
Decoding the molecular enigma behind asbestos and fibrous nanomaterial-induced carcinogenesis
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Occupational Health"
DOI: 10.1093/joccuh/uiae064
Abstract: Abstract Objectives: The natural fibrous mineral, asbestos, has been useful in industry for many centuries. In the 1960s, epidemiology recognized the association between asbestos exposure and mesothelioma, and in 1987 the International Agency for Research… read more here.
Keywords: mesothelial cells; iron; carcinogenesis; molecular mechanisms ... See more keywords
MMP‐7 affects peritoneal ultrafiltration associated with elevated aquaporin‐1 expression via MAPK/ERK pathway in peritoneal mesothelial cells
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16697
Abstract: Peritoneal membrane dysfunction and the resulting ultrafiltration failure are the major disadvantages of long‐term peritoneal dialysis (PD). It becomes increasingly clear that mesothelial cells play a vital role in the pathophysiological changes of the peritoneal… read more here.
Keywords: peritoneal ultrafiltration; mmp; mesothelial cells; peritoneal mesothelial ... See more keywords
Abstract 2524: MiR-29b may suppress peritoneal metastasis via the effects on peritoneal mesothelial cells as well as on tumor cells
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-2524
Abstract: Background: Peritoneal metastasis (PM) frequently occur in patients with gastric cancer with poor prognosis. Peritoneal cavity is lined with monolayer of mesothelial cells (MC) and contains various types of cells and exosomes. MC play an… read more here.
Keywords: mir; mesothelial cells; peritoneal metastasis; mir 29b ... See more keywords