Imatinib mesylate elicits extracellular signal-related kinase (ERK) activation and enhances the survival of γ-irradiated epithelial cells.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.10.095
Abstract: Imatinib mesylate, commercially known as Gleevec/Glivec, is the first targeted anticancer drug that inhibits activity of the tyrosine kinases, c-ABL, c-KIT, and PDGFR. A number of studies have shown that treatment with imatinib mesylate elicits… read more here.
Keywords: erk activation; imatinib mesylate; mesylate; mesylate elicits ... See more keywords
Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity
Sign Up to like & getrecommendations! Published in 2021 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2021.103255
Abstract: Background Antivirals are needed to combat the COVID-19 pandemic, which is caused by SARS-CoV-2. The clinically-proven protease inhibitor Camostat mesylate inhibits SARS-CoV-2 infection by blocking the virus-activating host cell protease TMPRSS2. However, antiviral activity of… read more here.
Keywords: antiviral activity; tmprss2; camostat mesylate; mesylate ... See more keywords
Green biosynthesis of magnetic iron oxide nanoparticles using Mentha longifolia for imatinib mesylate delivery
Sign Up to like & getrecommendations! Published in 2022 at "IET Nanobiotechnology"
DOI: 10.1049/nbt2.12090
Abstract: Abstract In this work, the rapid, facile, and eco‐friendly green process was introduced in the preparation of β‐cyclodextrin/magnetic iron oxide nanoparticles by using the aqueous Mentha longifolia extracts of Mentha longifolia. The obtained nanoparticles were… read more here.
Keywords: mesylate; imatinib mesylate; magnetic iron; mentha longifolia ... See more keywords
Case of bullous pemphigoid induced by apatinib mesylate
Sign Up to like & getrecommendations! Published in 2021 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.14583
Abstract: Bullous pemphigoid (BP) is a kind of immune bullous disease that often occurs in the elderly. Skin lesions manifest as pruritus papules or urticaria-like rash, accompanied by tension bullae. Immunopathology showed linear deposition of C3… read more here.
Keywords: treatment; bullous pemphigoid; case; mesylate ... See more keywords
Pharmacokinetic properties of pergolide mesylate following single and multiple-dose administration in donkeys (Equus asinus).
Sign Up to like & getrecommendations! Published in 2022 at "Equine veterinary journal"
DOI: 10.1111/evj.13917
Abstract: BACKGROUND Donkeys with clinical signs of PPID are treated with oral pergolide mesylate despite the lack of species-specific pharmacokinetic data. OBJECTIVES To evaluate the pharmacokinetics of intragastric and oral pergolide mesylate in healthy donkeys (Equus… read more here.
Keywords: mesylate; single multiple; administration; pergolide mesylate ... See more keywords
A Phase 1, Randomized, Open‐Label, Safety, Tolerability, and Comparative Bioavailability Study of Intranasal Dihydroergotamine Powder (STS101), Intramuscular Dihydroergotamine Mesylate, and Intranasal DHE Mesylate Spray in Healthy Adult Subjects
Sign Up to like & getrecommendations! Published in 2020 at "Headache"
DOI: 10.1111/head.13737
Abstract: To investigate and compare the safety and the pharmacokinetics of dihydroergotamine (DHE) after administration of intranasal DHE powder (STS101), intranasal DHE spray (Migranal®), and intramuscular (IM) DHE injection in healthy subjects. read more here.
Keywords: dihydroergotamine; powder sts101; intranasal dhe; mesylate ... See more keywords
Synthesis, Characterization, and Pharmacodynamics Study of Enrofloxacin Mesylate
Sign Up to like & getrecommendations! Published in 2020 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s239307
Abstract: Introduction Enrofloxacin is used in the treatment of a wide variety of bacterial infections in mammals. However, its poor solubility limits the clinical use. Methods In order to improve the solubility of enrofloxacin, the enrofloxacin… read more here.
Keywords: characterization; synthesis; mesylate; solubility ... See more keywords
Nafamostat mesylate attenuates the pathophysiologic sequelae of neurovascular ischemia
Sign Up to like & getrecommendations! Published in 2020 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.284981
Abstract: Nafamostat mesylate, an apparent soi-disant panacea of sorts, is widely used to anticoagulate patients undergoing hemodialysis or cardiopulmonary bypass, mitigate the inflammatory response in patients diagnosed with acute pancreatitis, and reverse the coagulopathy of patients… read more here.
Keywords: neuroprotective effects; ischemia nafamostat; nafamostat mesylate; mesylate ... See more keywords
A rare adverse drug reaction of imatinib mesylate
Sign Up to like & getrecommendations! Published in 2019 at "Indian Journal of Medical and Paediatric Oncology"
DOI: 10.4103/ijmpo.ijmpo_56_18
Abstract: A 45‐year‐old postmenopausal female came to the outpatient department with the complaints of upper abdominal pain and weight loss of 2 months duration. On examination, she had splenomegaly (4 cm size from the costal margin).… read more here.
Keywords: rare adverse; mesylate; adverse drug; reaction imatinib ... See more keywords