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Published in 2017 at "European journal of cancer"
DOI: 10.1016/j.ejca.2017.10.016
Abstract: PURPOSE Dysregulated MET signalling is implicated in oncogenesis. The safety and preliminary efficacy of a highly selective MET kinase inhibitor (SAR125844) was investigated in patients with advanced solid tumours and MET dysregulation. METHODS This was…
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Keywords:
met amplification;
kinase inhibitor;
selective met;
patients advanced ... See more keywords
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Published in 2021 at "ESMO open"
DOI: 10.1016/j.esmoop.2021.100319
Abstract: The rapidly changing treatment paradigm for patients with metastatic oncogene-driven lung cancer continues to evolve, and consequently our understanding of the landscape of resistance must also advance. MET amplification is an established and frequent driver…
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Keywords:
met amplification;
driver;
resistance;
lung cancer ... See more keywords
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Published in 2021 at "Cancer Investigation"
DOI: 10.1080/07357907.2021.1884695
Abstract: Abstract Comprehensive molecular testing of individual tumors has led to the identification of novel molecularly defined cancer therapies and treatment indications. Given low frequencies of many molecular alterations, efficacy of therapies used to target them…
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Keywords:
met amplification;
sinonasal undifferentiated;
case;
undifferentiated carcinoma ... See more keywords
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Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz431.004
Abstract: Abstract Background MET amplification is a rare genetic mutation which can be treated with small-molecule inhibitor-crizotinib. Based on the detection of next-generation sequencing, the molecular characteristics and the efficacy of crizotinib among different subsets of…
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Keywords:
met amplification;
crizotinib among;
efficacy crizotinib;
next generation ... See more keywords
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Published in 2020 at "Cancer Science"
DOI: 10.1111/cas.14593
Abstract: The third‐generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR‐TKI) osimertinib is approved for untreated, or previously EGFR‐TKI–treated T790M‐positive EGFR‐mutated non‐small cell lung carcinoma (NSCLC). We investigated the heterogeneity of responses to osimertinib and its…
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Keywords:
treated erlotinib;
egfr;
met amplification;
responses osimertinib ... See more keywords
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Published in 2019 at "BMC Research Notes"
DOI: 10.1186/s13104-019-4163-x
Abstract: ObjectiveGastric cancer is more open related to genetic predisposition. In our RNA sequencing study on gastric cancer patients, Runt-related transcription factor-3 (RUNX3) expression was significantly down-regulated in gastric cancer. We showed that decreased levels of…
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Keywords:
diffuse;
gastric cancer;
met amplification;
inc280 inhibits ... See more keywords
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Published in 2018 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2018.00305
Abstract: MET amplification is rare in treatment-naïve metastatic colorectal cancer (CRC) tumors, but can emerge as a mechanism of resistance to anti-EGFR therapies. Preclinical and clinical data suggest that patients with MET amplified tumors benefit from…
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Keywords:
metastatic colorectal;
response;
met amplification;
treatment ... See more keywords
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Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.645224
Abstract: Background Although C-ros oncogene 1 (ROS1) targeted therapies have demonstrated remarkable efficacy in ROS1-rearranged non-small cell lung cancer (NSCLC), patients inevitably develop resistance to ROS1-tyrosine kinase inhibitors (TKIs). Commonly acquired resistance mechanisms include a second…
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Keywords:
met amplification;
ros1 rearranged;
resistance;
case ... See more keywords
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Published in 2022 at "Cancers"
DOI: 10.3390/cancers14092150
Abstract: Simple Summary MET is a receptor tyrosine kinase encoded by the MET proto-oncogene that has a significant role in cancer cell progression. Several drugs targeting MET are under development for the treatment of different cancers,…
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Keywords:
met amplification;
targeted therapy;
treatment;
met targeted ... See more keywords
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Published in 2022 at "Cancers"
DOI: 10.3390/cancers14143444
Abstract: Simple Summary High MET copy-number variation (CNV) and high MET protein expression via MET exon 14 skipping mutation (METex14SM) are associated with tumorigenesis; however, METex14SM is rare in GC, so target therapy is rarely applicable.…
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Keywords:
cd44;
expression cd44;
met amplification;
expression ... See more keywords
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Published in 2017 at "Clinical laboratory"
DOI: 10.7754/clin.lab.2017.170407
Abstract: The study presented a case of lung squamous cell carcinoma (SCC) with de novo c-Met amplification. Four cycles of neoadjuvant chemotherapy were administered and partial response was achieved. Surgery was performed and the surgical margin…
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Keywords:
met amplification;
cell carcinoma;
squamous cell;
lung squamous ... See more keywords