Targeting the HGF/MET Axis in Cancer Therapy: Challenges in Resistance and Opportunities for Improvement
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DOI: 10.3389/fcell.2020.00152
Abstract: Among hundreds of thousands of signal receptors contributing to oncogenic activation, tumorigenesis, and metastasis, the hepatocyte growth factor (HGF) receptor – also called tyrosine kinase MET – is a promising target in cancer therapy as… read more here.
Keywords: hgf met; resistance; cancer therapy; met axis ... See more keywords
PFKP silencing suppresses tumor growth via the AXL-MET axis
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DOI: 10.7150/ijbs.100525
Abstract: PFKP (Phosphofructokinase, Platelet Type isoform), as an essential metabolic enzyme, contributes to the high glycolysis rates seen in cancers while its role in oncogenic pathways, especially from a non-metabolic aspect, is not fully understood. We… read more here.
Keywords: pfkp; met axis; axl met; pfkp silencing ... See more keywords