Tepotinib for advanced non-small-cell lung cancer with MET exon 14 skipping mutations
Sign Up to like & getrecommendations! Published in 2022 at "ESMO Open"
DOI: 10.1016/j.esmoop.2022.100449
Abstract: On 16 December 2021, the Committee for Medicinal Products for Human Use (CHMP) issued a positive opinion, recommending a marketing authorisation for tepotinib (Tepmetko, Merck KGaA, Darmstadt, Germany), an oral, highly selective mesenchymaleepithelial transition (MET)… read more here.
Keywords: skipping mutations; met gene; cell; lung cancer ... See more keywords
MET gene amplification is a mechanism of resistance to entrectinib in ROS1+ NSCLC
Sign Up to like & getrecommendations! Published in 2022 at "Thoracic Cancer"
DOI: 10.1111/1759-7714.14656
Abstract: ROS1 tyrosine kinase inhibitors (TKIs) have demonstrated significant clinical benefit for ROS1+ NSCLC patients. However, TKI resistance inevitably develops through ROS1 kinase domain (KD) modification or another kinase driving bypass signaling. While multiple TKIs have… read more here.
Keywords: amplification mechanism; ros1; ros1 nsclc; met gene ... See more keywords
An In silico Approach towards Finding the Cancer-Causing Mutations in Human MET Gene
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Genomics"
DOI: 10.1155/2023/9705159
Abstract: Mesenchymal–epithelial transition (MET) factor is a proto-oncogene encoding tyrosine kinase receptor with hepatocyte growth factor (HGF) or scatter factor (SF). It is found on the human chromosome number 7 and regulates the diverse cellular mechanisms… read more here.
Keywords: structure; approach towards; silico approach; met gene ... See more keywords
Increased MET gene copy number negatively affects the survival of esophageal squamous cell carcinoma patients
Sign Up to like & getrecommendations! Published in 2019 at "BMC Cancer"
DOI: 10.1186/s12885-019-5450-6
Abstract: BackgroundsSince Mesenchymal epithelial transition (MET) amplification has been regarded as a potential treatment target, the knowledge of its prevalence and prognostic importance is crucial. However, its clinical pathologic characteristics are not well known in esophageal… read more here.
Keywords: copy number; met gene; gene copy; met fish ... See more keywords
Comparison of the c-MET gene amplification between primary tumor and metastatic lymph nodes in non-small cell lung cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.e23138
Abstract: e23138Background: Activation of c-MET lead to a wide range of biological activities. MET has recently been identified as a novel promising target in NSCLC, some c-MET inhibitors have been developed... read more here.
Keywords: met gene; amplification primary; primary tumor; tumor metastatic ... See more keywords
MET gene alterations predict poor survival following chemotherapy in patients with advanced cancer
Sign Up to like & getrecommendations! Published in 2022 at "Pathology and Oncology Research"
DOI: 10.3389/pore.2022.1610697
Abstract: Background: To aid in oncology drug development, we investigated MET proto-oncogene receptor tyrosine kinase gene aberrations in 2,239 oncology patients who underwent next-generation sequencing (NGS) in clinical practice. Materials and methods: From November 2019 to… read more here.
Keywords: oncology; fusion; met gene; chemotherapy ... See more keywords
Cellular mesenchymal epithelial transition (C-MET) gene copy number variation in gastric adenocarcinoma: A pilot search for new marker for targeted therapy in HER-2/neu resistance
Sign Up to like & getrecommendations! Published in 2020 at "Indian Journal of Pathology and Microbiology"
DOI: 10.4103/ijpm.ijpm_396_19
Abstract: Increasing HER-2/neu resistance in gastric carcinoma has encouraged search for new biomarkers for targeted therapy. Cellular mesenchymal epithelial transition (C-MET) is one such tyrosine kinase inhibitor proposed for personalized salvage treatment. We determined frequency of… read more here.
Keywords: neu resistance; search new; met gene; targeted therapy ... See more keywords