Design, Synthesis, and Biological Evaluation of the First c-Met/HDAC Inhibitors Based on Pyridazinone Derivatives.
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DOI: 10.1021/acsmedchemlett.7b00172
Abstract: Simultaneous blockade of more than one pathway is considered to be a promising approach to overcome the low efficacy and acquired resistance of cancer therapies. Thus, a novel series of c-Met/HDAC bifunctional inhibitors was designed… read more here.
Keywords: design synthesis; biological evaluation; hdac inhibitors; evaluation first ... See more keywords