The potential therapeutic and prognostic impacts of the c‐MET/HGF signaling pathway in colorectal cancer
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DOI: 10.1002/iub.2063
Abstract: Colorectal cancer (CRC) is the third most common cancer and a common cause of cancer‐related mortality globally. In spite of the improvements in the early diagnosis of CRC, approximately one‐third of patients develop metastasis and… read more here.
Keywords: met hgf; hgf signaling; colorectal cancer; signaling pathway ... See more keywords
Simultaneous Targeting of Two Distinct Epitopes on MET Effectively Inhibits MET- and HGF-Driven Tumor Growth by Multiple Mechanisms
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DOI: 10.1158/1535-7163.mct-17-0374
Abstract: Increased MET activity is linked with poor prognosis and outcome in several human cancers currently lacking targeted therapies. Here, we report on the characterization of Sym015, an antibody mixture composed of two humanized IgG1 antibodies… read more here.
Keywords: met hgf; multiple mechanisms; epitopes met; sym015 ... See more keywords
The Emerging Role of the c-MET-HGF Axis in Non-small Cell Lung Cancer Tumor Immunology and Immunotherapy
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DOI: 10.3389/fonc.2020.00054
Abstract: Study of the c-Met-HGF axis in non-small cell lung cancer (NSCLC) has focused on the roles of c-MET signaling in neoplastic epithelial cells and the secretion of its ligand hepatocyte growth factor (HGF) by tumor… read more here.
Keywords: met hgf; hgf axis; axis non; role ... See more keywords
Corrigendum: The Emerging Role of the c-MET-HGF Axis in Non-small Cell Lung Cancer Tumor Immunology and Immunotherapy
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DOI: 10.3389/fonc.2020.01516
Abstract: [This corrects the article DOI: 10.3389/fonc.2020.00054.]. read more here.
Keywords: met hgf; emerging role; hgf axis; role met ... See more keywords
MET/HGF Co-Targeting in Pancreatic Cancer: A Tool to Provide Insight into the Tumor/Stroma Crosstalk
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DOI: 10.3390/ijms19123920
Abstract: The ‘onco-receptor’ MET (Hepatocyte Growth Factor Receptor) is involved in the activation of the invasive growth program that is essential during embryonic development and critical for wound healing and organ regeneration during adult life. When… read more here.
Keywords: met hgf; pancreatic cancer; stroma; crosstalk ... See more keywords
Foretinib Is Effective against Triple-Negative Breast Cancer Cells MDA-MB-231 In Vitro and In Vivo by Down-Regulating p-MET/HGF Signaling
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DOI: 10.3390/ijms24010757
Abstract: This study investigated the antitumor effects of foretinib on triple-negative breast cancer cells MDA-MB-231 xenograft tumors in vivo underlying phosphorylated mesenchymal to epithelial transition (p-MET)/ hepatocyte growth factor (HGF)-related mechanism, as well as its pharmacokinetic… read more here.
Keywords: breast cancer; met hgf; triple negative; mda 231 ... See more keywords