PIK3CA hotspot mutations differentially impact responses to MET targeting in MET-driven and non-driven preclinical cancer models
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Cancer"
DOI: 10.1186/s12943-017-0660-5
Abstract: BackgroundThe MET receptor tyrosine kinase represents a promising target in cancer. PIK3CA activating mutations are common in several tumor types and can potentially confer resistance to anti-receptor tyrosine kinase therapy.MethodsMET and/or PI3K pathway inhibition was… read more here.
Keywords: met driven; met inhibition; inhibition; resistance ... See more keywords
Acquired resistance to MET inhibition in MET driven NSCLC.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.9030
Abstract: 9030 Background: MET mutations ( MET∆ex14), amplifications or translocations can activate oncogenic signaling in lung cancer and are sensitive to MET inhibition. Acquired resistance to therapy with MET tyrosine kinase inhibitors (TKI) occurs inevitably. Methods:… read more here.
Keywords: patient; response; met inhibition; resistance ... See more keywords
c-MET Inhibition: Novel Treatment for Sporadic and MEN1-associated GEP NET.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular endocrinology"
DOI: 10.1530/jme-20-0020
Abstract: Gastroenteropancreatic (GEP) neuroendocrine tumors (NETs) comprise a heterogenous and diverse group of neoplasms arising from a common neuroendocrine cell origin. The majority of these tumors occur sporadically while ~20% manifest within the context of hereditary… read more here.
Keywords: met inhibition; men1 associated; sporadic men1; men1 ... See more keywords
MET Inhibition Sensitizes Rhabdomyosarcoma Cells to NOTCH Signaling Suppression
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.835642
Abstract: Rhabdomyosarcoma (RMS) is a pediatric myogenic soft tissue sarcoma. The Fusion-Positive (FP) subtype expresses the chimeric protein PAX3-FOXO1 (P3F) while the Fusion-Negative (FN) is devoid of any gene translocation. FP-RMS and metastatic FN-RMS are often… read more here.
Keywords: cell lines; notch signaling; inhibition; met inhibition ... See more keywords
Cancer Cells Haploinsufficient for ATM Are Sensitized to PARP Inhibitors by MET Inhibition
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23105770
Abstract: The MET oncogene encodes a tyrosine kinase (TK) receptor. Its activation protects cells from death but also stimulates DNA damage response by triggering excess replicative stress. Transcriptomic classification of cancer cell lines based on MET… read more here.
Keywords: cell; inhibition; met inhibition; haploinsufficient atm ... See more keywords