Ezrin mediates both HGF/Met autocrine and non‐autocrine signaling‐induced metastasis in melanoma
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Cancer"
DOI: 10.1002/ijc.31196
Abstract: Aberrant HGF/Met signaling promotes tumor migration, invasion, and metastasis through both autocrine and non‐autocrine mechanisms; however, the molecular downstream signaling mechanisms by which HGF/Met induces metastasis are incompletely understood. We here report that Ezrin expression… read more here.
Keywords: autocrine; non autocrine; hgf met; metastasis ... See more keywords
Progress on treatment of MET signaling pathway in non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Clinical Oncology"
DOI: 10.1007/s10147-020-01702-0
Abstract: MET activation includes gene mutation, amplification, and protein overexpression. Clinical evidence suggests that MET activation is both a primary oncogenic driver in lung cancer, and a secondary driver after acquired resistance to EGFR tyrosine kinase… read more here.
Keywords: treatment met; progress treatment; lung cancer; met signaling ... See more keywords
Disrupted Timing of MET Signaling Derails the Developmental Maturation of Cortical Circuits and Leads to Altered Behavior in Mice.
Sign Up to like & getrecommendations! Published in 2021 at "Cerebral cortex"
DOI: 10.1093/cercor/bhab323
Abstract: The molecular regulation of the temporal dynamics of circuit maturation is a key contributor to the emergence of normal structure-function relations. Developmental control of cortical MET receptor tyrosine kinase, expressed early postnatally in subpopulations of… read more here.
Keywords: cortical circuits; disrupted timing; leads altered; circuits leads ... See more keywords
Alterations in the proteome of developing neocortical synaptosomes in the absence of MET signaling revealed by comparative proteomics.
Sign Up to like & getrecommendations! Published in 2023 at "Developmental neuroscience"
DOI: 10.1159/000529981
Abstract: Alterations in the expression of genes encoding proteins involved in synapse formation, maturation and function are a hallmark of many neurodevelopmental and psychiatric disorders. For example, there is reduced neocortical expression of the MET receptor… read more here.
Keywords: proteome developing; developing neocortical; alterations proteome; met signaling ... See more keywords
Hypoxic stress disrupts HGF/Met signaling in human trophoblasts: implications for the pathogenesis of preeclampsia
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomedical Science"
DOI: 10.1186/s12929-022-00791-5
Abstract: Background Preeclampsia (PE), a placenta-associated pregnancy complication, is the leading cause of maternal and perinatal morbidity and mortality. Met/Erk signaling is inhibited in the placentas of patients with early-onset preeclampsia (E-PE), but the underlying mechanisms… read more here.
Keywords: hgf met; endocytosis; met signaling; pathogenesis preeclampsia ... See more keywords
Reduced HGF/MET Signaling May Contribute to the Synaptic Pathology in an Alzheimer's Disease Mouse Model
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.954266
Abstract: Alzheimer's disease (AD) is a neurodegenerative disorder strongly associates with aging. While amyloid plagues and neurofibrillary tangles are pathological hallmarks of AD, recent evidence suggests synaptic dysfunction and physical loss may be the key mechanisms… read more here.
Keywords: hgf met; alzheimer disease; pathology; met signaling ... See more keywords
The Role of HGF/MET Signaling in Metastatic Uveal Melanoma
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13215457
Abstract: Simple Summary Hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor (MET) signaling plays an important role in the metastatic formation and therapeutic resistance to uveal melanoma. Here, we review the various functions of MET signaling contributing to… read more here.
Keywords: uveal melanoma; hgf met; met signaling; metastatic uveal ... See more keywords
Hepatocyte Growth Factor/c-Met Signaling in Head and Neck Cancer and Implications for Treatment
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DOI: 10.3390/cancers9040039
Abstract: Aberrant signaling of the hepatocyte growth factor (HGF)/c-Met pathway has been identified as a promoter of tumorigenesis in several tumor types including head and neck squamous cell carcinoma (HNSCC). Despite a relatively low c-Met mutation… read more here.
Keywords: hgf met; growth factor; hnscc; met signaling ... See more keywords
Extracellular Matrix Influencing HGF/c-MET Signaling Pathway: Impact on Cancer Progression
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DOI: 10.3390/ijms19113300
Abstract: The extracellular matrix (ECM) is a crucial component of the tumor microenvironment involved in numerous cellular processes that contribute to cancer progression. It is acknowledged that tumor–stromal cell communication is driven by a complex and… read more here.
Keywords: extracellular matrix; hgf met; signaling pathway; cancer progression ... See more keywords
MET Signaling Pathways, Resistance Mechanisms, and Opportunities for Target Therapies
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232213898
Abstract: The MET gene, known as MET proto-oncogene receptor tyrosine kinase, was first identified to induce tumor cell migration, invasion, and proliferation/survival through canonical RAS-CDC42-PAK-Rho kinase, RAS-MAPK, PI3K-AKT-mTOR, and β-catenin signaling pathways, and its driver mutations,… read more here.
Keywords: target therapies; met signaling; resistance; pathways resistance ... See more keywords