Quantitation of ligand is critical for ligand-dependent MET signalling activation and determines MET-targeted therapeutic response in gastric cancer
Sign Up to like & getrecommendations! Published in 2020 at "Gastric Cancer"
DOI: 10.1007/s10120-020-01139-4
Abstract: Despite the promising preclinical antitumor activity of MET-targeting therapies, most clinical trials have failed. We introduced a new concept of quantitation of stroma-induced hepatocyte growth factor (HGF) to assess the actual MET signalling activity in… read more here.
Keywords: gastric cancer; ligand dependent; met signalling; signalling activation ... See more keywords
Transactivation of Met signalling by semaphorin4D in human placenta: implications for the pathogenesis of preeclampsia
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DOI: 10.1097/hjh.0000000000001808
Abstract: Objective: The signalling of the receptor tyrosine kinase Met is critical in promoting trophoblast cell invasion, and the deficiency in HGF/Met signalling is associated with preeclampsia. The semaphorin family member semaphorin4D (sema4D) and its receptor… read more here.
Keywords: sema4d; invasion; sema4d plexin; met signalling ... See more keywords