Quantitation of ligand is critical for ligand-dependent MET signalling activation and determines MET-targeted therapeutic response in gastric cancer
Sign Up to like & getrecommendations! Published in 2020 at "Gastric Cancer"
DOI: 10.1007/s10120-020-01139-4
Abstract: Despite the promising preclinical antitumor activity of MET-targeting therapies, most clinical trials have failed. We introduced a new concept of quantitation of stroma-induced hepatocyte growth factor (HGF) to assess the actual MET signalling activity in… read more here.
Keywords: gastric cancer; ligand dependent; met signalling; signalling activation ... See more keywords
Transactivation of Met signalling by semaphorin4D in human placenta: implications for the pathogenesis of preeclampsia
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DOI: 10.1097/hjh.0000000000001808
Abstract: Objective: The signalling of the receptor tyrosine kinase Met is critical in promoting trophoblast cell invasion, and the deficiency in HGF/Met signalling is associated with preeclampsia. The semaphorin family member semaphorin4D (sema4D) and its receptor… read more here.
Keywords: sema4d; invasion; sema4d plexin; met signalling ... See more keywords
Targeting MET Signalling Activated by CPNE3‐RACK1 Interaction Through VWFA Domain to Suppress Lung Cancer Progression
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.70926
Abstract: Despite advances in diagnosis and treatment, the prognosis of non‐small cell lung cancer (NSCLC) remains poor. Therefore, it is urgent to identify potential molecular targets. In this study, we investigated the function and internal mechanism… read more here.
Keywords: rack1; lung cancer; vwfa domain; cpne3 ... See more keywords