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   Articles with "meta functionalization" as a keyword



Emergence of Pyrimidine-Based meta-Directing Group: Journey from Weak to Strong Coordination in Diversifying meta-C-H Functionalization.

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recommendations! Published in 2022 at "Accounts of chemical research"

DOI: 10.1021/acs.accounts.1c00629

Abstract: ConspectusC-H activation has emerged as a powerful transformative synthetic tool to construct complex molecular frameworks, which are ubiquitous in natural products, medicines, dyes, polymers, and many more. However, reactivity and selectivity, arising from the inertness… read more here.

Keywords: meta; meta functionalization; directing group; activation ... See more keywords

Diverse meta-C–H Functionalization of Amides

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recommendations! Published in 2020 at "ACS Catalysis"

DOI: 10.1021/acscatal.0c01306

Abstract: Overriding the preference for favorable proximal metalation by ortho-directing amide group, a pyrimidine-based directing group (DG) has been demonstrated for diverse remote meta-C–H functionalizati... read more here.

Keywords: meta functionalization; diverse meta; functionalization amides;

Palladium Catalyzed meta-C-H Functionalization of Masked Aromatic Aldehydes.

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recommendations! Published in 2018 at "ACS catalysis"

DOI: 10.1021/acscatal.8b01599

Abstract: Palladium catalyzed meta-C-H functionalization enabled by transient mediators has the potential to extend the utility of directed ortho-C-H functionalization to remote positions. However, there have been no reports of palladium catalyzed meta-C-H functionalization of aromatic… read more here.

Keywords: functionalization masked; meta functionalization; palladium catalyzed; masked aromatic ... See more keywords

Atroposelective Diverse Remote meta-C-H Functionalization via Kinetic Resolution.

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recommendations! Published in 2025 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.4c15491

Abstract: A diverse range of Pd(II)-catalyzed enantioselective C-H activation reactions have been developed to construct point, axial, and planar chirality. Despite the importance of chiral biaryl scaffolds in bioactive molecules and chiral ligands, atroposelective functionalization at… read more here.

Keywords: remote meta; meta; functionalization; via kinetic ... See more keywords

Radical and ionic meta-C–H functionalization of pyridines, quinolines, and isoquinolines

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recommendations! Published in 2022 at "Science"

DOI: 10.1126/science.ade6029

Abstract: Carbon-hydrogen (C−H) functionalization of pyridines is a powerful tool for the rapid construction and derivatization of many agrochemicals, pharmaceuticals, and materials. Because of the inherent electronic properties of pyridines, selective meta-C−H functionalization is challenging. Here,… read more here.

Keywords: functionalization pyridines; meta functionalization; functionalization; meta ... See more keywords