Emergence of Pyrimidine-Based meta-Directing Group: Journey from Weak to Strong Coordination in Diversifying meta-C-H Functionalization.
Sign Up to like & getrecommendations! Published in 2022 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.1c00629
Abstract: ConspectusC-H activation has emerged as a powerful transformative synthetic tool to construct complex molecular frameworks, which are ubiquitous in natural products, medicines, dyes, polymers, and many more. However, reactivity and selectivity, arising from the inertness… read more here.
Keywords: meta; meta functionalization; directing group; activation ... See more keywords
Diverse meta-C–H Functionalization of Amides
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DOI: 10.1021/acscatal.0c01306
Abstract: Overriding the preference for favorable proximal metalation by ortho-directing amide group, a pyrimidine-based directing group (DG) has been demonstrated for diverse remote meta-C–H functionalizati... read more here.
Keywords: meta functionalization; diverse meta; functionalization amides;
Palladium Catalyzed meta-C-H Functionalization of Masked Aromatic Aldehydes.
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DOI: 10.1021/acscatal.8b01599
Abstract: Palladium catalyzed meta-C-H functionalization enabled by transient mediators has the potential to extend the utility of directed ortho-C-H functionalization to remote positions. However, there have been no reports of palladium catalyzed meta-C-H functionalization of aromatic… read more here.
Keywords: functionalization masked; meta functionalization; palladium catalyzed; masked aromatic ... See more keywords
Radical and ionic meta-C–H functionalization of pyridines, quinolines, and isoquinolines
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DOI: 10.1126/science.ade6029
Abstract: Carbon-hydrogen (C−H) functionalization of pyridines is a powerful tool for the rapid construction and derivatization of many agrochemicals, pharmaceuticals, and materials. Because of the inherent electronic properties of pyridines, selective meta-C−H functionalization is challenging. Here,… read more here.
Keywords: functionalization pyridines; meta functionalization; functionalization; meta ... See more keywords