Generalizability of "GWAS Hits" in Clinical Populations: Lessons from Childhood Cancer Survivors.
Sign Up to like & getrecommendations! Published in 2020 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2020.08.014
Abstract: With mounting interest in translating genome-wide association study (GWAS) hits from large meta-analyses (meta-GWAS) in diverse clinical settings, evaluating their generalizability in target populations is crucial. Here, we consider long-term survivors of childhood cancers from… read more here.
Keywords: generalizability; gwas hits; meta gwas; childhood cancer ... See more keywords
Metasubtract: an R‐package to analytically produce leave‐one‐out meta‐analysis GWAS summary statistics
Sign Up to like & getrecommendations! Published in 2020 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btaa570
Abstract: Abstract Summary Summary statistics from a meta‐analysis of genome‐wide association studies (meta-GWAS) can be used for many follow-up analyses. One valuable application is the creation of polygenic scores. However, if polygenic scores are calculated in… read more here.
Keywords: meta gwas; cohort; meta; gwas ... See more keywords
Integrating large-scale meta-GWAS and PigGTEx resources to decipher the genetic basis of 232 complex traits in pigs
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DOI: 10.1093/nsr/nwaf048
Abstract: ABSTRACT Understanding the molecular and cellular mechanisms underlying complex traits in pigs is crucial for enhancing genetic gain via artificial selection and utilizing pigs as models for human disease and biology. Here, we conducted comprehensive… read more here.
Keywords: 232 complex; meta; meta gwas; complex traits ... See more keywords