Generalizability of "GWAS Hits" in Clinical Populations: Lessons from Childhood Cancer Survivors.
Sign Up to like & getrecommendations! Published in 2020 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2020.08.014
Abstract: With mounting interest in translating genome-wide association study (GWAS) hits from large meta-analyses (meta-GWAS) in diverse clinical settings, evaluating their generalizability in target populations is crucial. Here, we consider long-term survivors of childhood cancers from… read more here.
Keywords: generalizability; gwas hits; meta gwas; childhood cancer ... See more keywords
Metasubtract: an R‐package to analytically produce leave‐one‐out meta‐analysis GWAS summary statistics
Sign Up to like & getrecommendations! Published in 2020 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btaa570
Abstract: Abstract Summary Summary statistics from a meta‐analysis of genome‐wide association studies (meta-GWAS) can be used for many follow-up analyses. One valuable application is the creation of polygenic scores. However, if polygenic scores are calculated in… read more here.
Keywords: meta gwas; cohort; meta; gwas ... See more keywords