Transcriptomics and metabolomics reveal the role of CYP1A2 in psoralen/isopsoralen‐induced metabolic activation and hepatotoxicity
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7604
Abstract: Psoralen and isopsoralen are the pharmacologically important but hepatotoxic components in Psoraleae Fructus. The purpose of this study was to reveal the underlying mechanism of psoralen/isopsoralen‐induced hepatotoxicity. Initially, we applied integrated analyses of transcriptomic and… read more here.
Keywords: isopsoralen induced; psoralen isopsoralen; role cyp1a2; metabolic activation ... See more keywords
In vitro and in vivo studies of the metabolic activation of chelidonine.
Sign Up to like & getrecommendations! Published in 2019 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2019.05.012
Abstract: Chelidonium majus L. is a herbal medicine widely employed in Europe and Western Asia. Chelidonine (CHE) is a major constituent of the herb and has been reported to be an inhibitor of the cytochrome P450… read more here.
Keywords: metabolic activation; vitro vivo; che; vivo studies ... See more keywords
Genotoxicity studies on plant growth promoting smoke-water and smoke-derived compounds using Vicia faba and Persea americana S10 metabolic activation
Sign Up to like & getrecommendations! Published in 2017 at "South African Journal of Botany"
DOI: 10.1016/j.sajb.2017.06.020
Abstract: Abstract The potential agricultural or horticultural use of ‘smoke technology’ has received considerable attention since plant-derived smoke-water or smoke-derived compounds can play an intriguing role in seed germination and seedling vigor. However, it is of… read more here.
Keywords: water; metabolic activation; smoke water; water smoke ... See more keywords
Metabolic Activation of Militarine In Vitro and In Vivo.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.1c00430
Abstract: Bletilla striata is consumed as food and herbal medicine. Militarine (MLT) is a major ingredient in B. striata. Previous studies demonstrated that MLT showed teratogenic toxicity to zebrafish embryos. The present study aimed to identify… read more here.
Keywords: activation militarine; metabolic activation; militarine; quinone methide ... See more keywords
In Vitro and In Vivo Metabolic Activation and Hepatotoxicity of Environmental Pollutant 2,6-Dimethylphenol.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.2c00048
Abstract: 2,6-Dimethylphenol (2,6-DMP) is an environmental pollutant found in industrial wastewater. Exposure to 2,6-DMP is of increasing concern as it endangered reportedly some aquatic animals. In this study, we investigated the metabolic activation and hepatotoxicity of… read more here.
Keywords: vitro vivo; environmental pollutant; metabolic activation; hepatotoxicity ... See more keywords
Cytochromes P450 2C8 and 3A Catalyze the Metabolic Activation of the Tyrosine Kinase Inhibitor Masitinib.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.2c00057
Abstract: Masitinib is a small molecule tyrosine kinase inhibitor under investigation for the treatment of amyotrophic lateral sclerosis, mastocytosis, and COVID-19. Hepatotoxicity has been reported in some patients while taking masitinib. The liver injury is thought… read more here.
Keywords: metabolic activation; kinase inhibitor; p450; tyrosine kinase ... See more keywords
Role of Human Aldo-Keto Reductases and Nuclear Factor Erythroid 2-Related Factor 2 in the Metabolic Activation of 1-Nitropyrene via Nitroreduction in Human Lung Cells.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.2c00337
Abstract: 1-Nitropyrene (1-NP) is a constituent of diesel exhaust and classified as a group 2A probable human carcinogen. The metabolic activation of 1-NP by nitroreduction generates electrophiles that can covalently bind DNA to form mutations to… read more here.
Keywords: metabolic activation; keto reductases; factor; nitroreduction ... See more keywords
In Vitro and In Vivo Metabolic Activation of Tolterodine Mediated by CYP3A.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.2c00389
Abstract: Tolterodine (TOL) is an antimuscarinic drug used for the treatment of patients with overactive bladder presenting urinary frequency, urgency, and urge incontinence. During the clinical use of TOL, adverse events such as liver injury took… read more here.
Keywords: tolterodine; metabolic activation; gsh conjugate; tol ... See more keywords
Immunochemical and LC-MS/MS Detection of Protein Adduction Resulting from Metabolic Activation of Columbin In Vitro and In Vivo.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.3c00006
Abstract: Columbin (CLB) is a diterpenoid furanolactone compound occurring in some herbal medicines. Administration of CLB has been reported to induce liver injury. The reported CLB hepatotoxicity is suggested to require metabolism to a cis-enedial intermediate.… read more here.
Keywords: resulting metabolic; metabolic activation; adduction resulting; adduction ... See more keywords
Identification of Key Toxic Substances Considering Metabolic Activation: A Combination of Transcriptome and Nontarget Analysis.
Sign Up to like & getrecommendations! Published in 2024 at "Environmental science & technology"
DOI: 10.1021/acs.est.4c03683
Abstract: There have been numerous studies using effect-directed analysis (EDA) to identify key toxic substances present in source and drinking water, but none of these studies have considered the effects of metabolic activation. This study developed… read more here.
Keywords: metabolic activation; identification; toxic substances; key toxic ... See more keywords
Insect-Mediated Metabolic Activation of Etofenprox Amplifies Hidden Aquatic Toxicity in Rice Ecosystems.
Sign Up to like & getrecommendations! Published in 2025 at "Environmental science & technology"
DOI: 10.1021/acs.est.5c11107
Abstract: Pyrethroid insecticides, though effective against pests, often exhibit high toxicity to aquatic organisms. A notable exception is etofenprox, which is uniquely approved for rice paddies due to its low aquatic toxicity. However, this study uncovers… read more here.
Keywords: metabolic activation; rice; toxicity; aquatic toxicity ... See more keywords