Nqo1 ablation inhibits activation of the PI3K/Akt and MAPK/ERK pathways and blocks metabolic adaptation in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30818
Abstract: Cancer cells undergo metabolic adaptation to sustain uncontrolled proliferation. Aerobic glycolysis and glutaminolysis are two of the most essential characteristics of cancer metabolic reprogramming. Hyper-activated PI3K/Akt and MAPK/ERK signaling pathways play central roles in cancer… read more here.
Keywords: erk; pi3k akt; metabolic adaptation; akt mapk ... See more keywords
Peripheral thyroid hormone deiodination: Entry points to elucidate mechanisms of metabolic adaptation during weight regain
Sign Up to like & getrecommendations! Published in 2023 at "Obesity"
DOI: 10.1002/oby.23721
Abstract: The concept of dual‐adaptive thermogenesis underlying metabolic adaptation to prolonged energy deficit posits that there are two control systems that govern energy sparing: a rapid‐reacting system to energy deficit and a slow‐reacting system to fat… read more here.
Keywords: weight regain; metabolic adaptation; thyroid; entry points ... See more keywords
Modifications of Resting Energy Expenditure After Sleeve Gastrectomy
Sign Up to like & getrecommendations! Published in 2018 at "Obesity Surgery"
DOI: 10.1007/s11695-018-3190-3
Abstract: ObjectivesResting energy expenditure (REE) declines more than what is expected according to body composition changes after caloric restriction. This metabolic adaptation is considered one of the factors favoring weight regain. The aim of this study… read more here.
Keywords: metabolic adaptation; energy expenditure; sleeve gastrectomy; loss ... See more keywords
2SBP: overview of the trans-omics session—measure × analyze metabolic adaptation of biological systems—at the 2019 BSJ Meeting in Miyazaki
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical Reviews"
DOI: 10.1007/s12551-020-00660-1
Abstract: Elucidation of the molecular mechanism underlying the metabolic adaptation is critical to understand homeostasis of life. This review provides the concept, experimental and computational methods, to deal with this issue using “trans-omics” approaches. read more here.
Keywords: 2sbp overview; trans omics; metabolic adaptation; omics session ... See more keywords
Understanding metabolic adaptation by using bacterial laboratory evolution and trans-omics analysis
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical Reviews"
DOI: 10.1007/s12551-020-00695-4
Abstract: Many diseases such as metabolic syndrome, cancer, inflammatory diseases, and pathological phenomena can be understood as an adaptive reconstitution of the metabolic state (metabolic adaptation). One of the effective approaches to reveal the property of… read more here.
Keywords: laboratory evolution; bacterial laboratory; metabolic adaptation; understanding metabolic ... See more keywords
Mitochondrial Dynamics: Shaping Metabolic Adaptation.
Sign Up to like & getrecommendations! Published in 2018 at "International review of cell and molecular biology"
DOI: 10.1016/bs.ircmb.2018.05.004
Abstract: Despite their classic bean-shaped depiction, mitochondria have very different aspects in each cell type. From long filamentous structures to punctuated small round organelles. These shapes can dynamically change in response to nutrients and in situations… read more here.
Keywords: dynamics shaping; metabolic adaptation; biology; mitochondrial dynamics ... See more keywords
Metabolic adaptation of macrophages in chronic diseases.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2017.11.023
Abstract: In response to physiological and pathological stimuli, macrophages are able to adapt and shape their phenotype, giving rise to a broad range of functional activation that is unique in different organs and different pathologies. The… read more here.
Keywords: chronic diseases; adaptation macrophages; metabolic adaptation; macrophage ... See more keywords
Association between ketosis and metabolic adaptation at the level of resting metabolic rate.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical nutrition"
DOI: 10.1016/j.clnu.2021.06.029
Abstract: BACKGROUND The ketone body β-hydroxybutyrate (βHB) has been shown to act as a signaling molecule that regulates metabolism and energy homeostasis during starvation in animal models. A potential association between βHB and metabolic adaptation (a… read more here.
Keywords: adaptation level; ketosis; metabolic adaptation; association ... See more keywords
Metabolic Adaptation of a Globally Important Diatom following 700 Generations of Selection under a Warmer Temperature.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental science & technology"
DOI: 10.1021/acs.est.1c08584
Abstract: Diatoms, accounting for 40% of the marine primary production and 20% of global carbon dioxide fixation, are threatened by the ongoing ocean warming (OW). However, whether and how these ecologically important phytoplankton adapt to OW… read more here.
Keywords: 700 generations; generations selection; adaptation globally; metabolic adaptation ... See more keywords
Structural and metabolic adaptation of cellulolytic microcosm in co-digested Napier grass-swine manure and its application in enhancing thermophilic biogas production
Sign Up to like & getrecommendations! Published in 2018 at "RSC Advances"
DOI: 10.1039/c8ra05616a
Abstract: Biogas production from cellulosic wastes has received increasing attention. However, its efficiency is limited by the recalcitrant nature of plant cell wall materials. In this study, an active and structurally stable lignocellulolytic microcosm (PLMC) was… read more here.
Keywords: biogas production; swine manure; napier grass; metabolic adaptation ... See more keywords
Metabolic adaptation of pigs to a Mycoplasma hyopneumoniae and Lawsonia intracellularis dual challenge.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of animal science"
DOI: 10.1093/jas/sky220
Abstract: Respiratory and enteric pathogens such as Mycoplasma hyopneumoniae (Mh) and Lawsonia intracellularis (LI) reduce lean accretion and feed efficiency (FE) in growing pigs. However, the metabolic mechanism by which this occurs is still unknown. Therefore,… read more here.
Keywords: mhli; challenge; mycoplasma hyopneumoniae; metabolic adaptation ... See more keywords