Pharmacotherapy for metabolic and cellular stress in degenerative retinal diseases.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2019.11.013
Abstract: Retinal photoreceptors continually endure stresses associated with prolonged light exposure and the metabolic demands of dark adaptation. Although healthy photoreceptors are able to withstand these stresses for several decades, the disease-affected retina functions at a… read more here.
Keywords: degenerative retinal; metabolic cellular; cellular stress; pharmacotherapy metabolic ... See more keywords
Δ133p53α enhances metabolic and cellular fitness of TCR-engineered T cells and promotes superior antitumor immunity
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DOI: 10.1136/jitc-2020-001846
Abstract: Background Tumor microenvironment-associated T cell senescence is a key limiting factor for durable effective cancer immunotherapy. A few studies have demonstrated the critical role of the tumor suppressor TP53-derived p53 isoforms in cellular senescence process… read more here.
Keywords: enhances metabolic; metabolic cellular; antitumor; cell ... See more keywords
Chemical, Metabolic, and Cellular Characterization of a FtsZ Inhibitor Effective Against Burkholderia cenocepacia
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DOI: 10.3389/fmicb.2020.00562
Abstract: There is an urgent need for new antimicrobials to treat the opportunistic Gram-negative Burkholderia cenocepacia, which represents a problematic challenge for cystic fibrosis patients. Recently, a benzothiadiazole derivative, C109, was shown to be effective against… read more here.
Keywords: chemical metabolic; ftsz; burkholderia; burkholderia cenocepacia ... See more keywords
Metabolic and Cellular Compartments of Acetyl-CoA in the Healthy and Diseased Brain
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DOI: 10.3390/ijms231710073
Abstract: The human brain is characterised by the most diverse morphological, metabolic and functional structure among all body tissues. This is due to the existence of diverse neurons secreting various neurotransmitters and mutually modulating their own… read more here.
Keywords: metabolic cellular; acetyl coa; brain; cellular compartments ... See more keywords