Titer improvement of milbemycins via coordinating metabolic competition and transcriptional co‐activation controlled by Streptomyces antibiotic regulatory protein family regulator in Streptomyces bingchenggensis
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DOI: 10.1002/bit.28044
Abstract: Streptomyces bingchenggensis is a promising producer of milbemycins (MILs), the macrolide pesticide used widely in agriculture. The relationship between different biosynthetic gene clusters (BGCs) and the MIL BGC remains unclear, which hinders the precise metabolic… read more here.
Keywords: titer improvement; metabolic competition; regulatory protein; titer ... See more keywords
Activated B cells suppress T-cell function through metabolic competition
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DOI: 10.1136/jitc-2022-005644
Abstract: Background B cells play a pivotal role in regulating the immune response. The induction of B cell-mediated immunosuppressive function requires B cell activating signals. However, the mechanisms by which activated B cells mediate T-cell suppression… read more here.
Keywords: activated cells; cell; function; metabolic competition ... See more keywords