Prolonged overnutrition with fructose or fat induces metabolic derangements in rats by disrupting the crosstalk between the hypothalamus and periphery: Possible amelioration with fenofibrate.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173136
Abstract: Metabolic Syndrome (MetS) increases the risk of developing type 2 diabetes mellitus and cardiovascular complications. The crosstalk between the hypothalamus and periphery is vital for regulating food intake and energy homeostasis. However, it is impaired… read more here.
Keywords: crosstalk hypothalamus; group; hypothalamus periphery; fenofibrate ... See more keywords
Burn-induced muscle metabolic derangements and mitochondrial dysfunction are associated with activation of HIF-1α and mTORC1: Role of protein farnesylation
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DOI: 10.1038/s41598-017-07011-3
Abstract: Metabolic derangements are a clinically significant complication of major trauma (e.g., burn injury) and include various aspects of metabolism, such as insulin resistance, muscle wasting, mitochondrial dysfunction and hyperlactatemia. Nonetheless, the molecular pathogenesis and the… read more here.
Keywords: protein farnesylation; muscle; dysfunction; burn induced ... See more keywords
Experimental animal models of coronary microvascular dysfunction
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DOI: 10.1093/cvr/cvaa002
Abstract: Abstract Coronary microvascular dysfunction (CMD) is commonly present in patients with metabolic derangements and is increasingly recognized as an important contributor to myocardial ischaemia, both in the presence and absence of epicardial coronary atherosclerosis. The… read more here.
Keywords: microvascular dysfunction; animal models; inoca; metabolic derangements ... See more keywords
Identifying encephalopathies from acute metabolic derangements
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DOI: 10.1111/joim.13538
Abstract: Metabolic derangements, when acute and severe, affect brain function. This presents mostly with a marked decline in the level of consciousness, resulting in impaired responsiveness, abnormal receptivity, impaired content, and loss of memory retention. The… read more here.
Keywords: metabolic derangements; encephalopathies acute; brain; identifying encephalopathies ... See more keywords
Do metabolic derangements in end‐stage polycystic kidney disease differ versus other primary kidney diseases?
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DOI: 10.1111/nep.12927
Abstract: Autosomal dominant polycystic kidney disease (ADPKD), a systemic disorder caused by mutation in genes encoding polycystins, has been reported to lead to metabolic derangements including new‐onset diabetes mellitus after kidney transplantation. We analyzed markers of… read more here.
Keywords: kidney; disease; polycystic kidney; end stage ... See more keywords
Circulating cell-free double-stranded DNA and metabolic derangements in idiopathic pulmonary fibrosis: a new association
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DOI: 10.1136/thoraxjnl-2021-218192
Abstract: The study by Whalen et al has delineated the association between circulating cellfree DNA (ccfDNA) and metabolic derangements in idiopathic pulmonary fibrosis (IPF). They examined healthy controls compared with slow and rapid progressors. The latter… read more here.
Keywords: dna; ccfdna; derangements idiopathic; idiopathic pulmonary ... See more keywords
Metabolic Derangements Contribute to Reduced sRAGE Isoforms in Subjects with Alzheimer's Disease
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DOI: 10.1155/2018/2061376
Abstract: Although there is evidence for metabolic dysfunction and chronic inflammation in Alzheimer's disease (AD), circulating levels of soluble receptor for advanced glycation end products (sRAGE) and the receptor for advanced glycation end products (RAGE) ligand… read more here.
Keywords: contribute reduced; derangements contribute; alzheimer disease; srage ... See more keywords
Possible Role of GnIH as a Novel Link between Hyperphagia-Induced Obesity-Related Metabolic Derangements and Hypogonadism in Male Mice
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DOI: 10.3390/ijms23158066
Abstract: Gonadotropin-inhibitory hormone (GnIH) is a reproductive inhibitor and an endogenous orexigenic neuropeptide that may be involved in energy homeostasis and reproduction. However, whether GnIH is a molecular signal link of metabolism and the reproductive system,… read more here.
Keywords: gnih; metabolic derangements; obesity related; mice ... See more keywords