Harnessing the Integrated Stress Response to Counteract Metabolic Disease
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.30152
Abstract: Over a decade ago, fibroblast growth factor 21 (FGF21) was identified as a novel regulator of metabolism (1). Since that time, accumulating data have substantiated the therapeutic potential of this hormone in counteracting metabolic disease.… read more here.
Keywords: metabolic disease; integrated stress; disease; stress response ... See more keywords
Metabolic disease in the Pacific: Lessons for indigenous populations
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12495
Abstract: Twenty‐five percent of the New Zealand population is either Māori or Pacific and are thus indigenous to the region. The New Zealand National Metabolic Service has considerable experience in diagnosing and managing metabolic diseases in… read more here.
Keywords: indigenous populations; populations metabolic; disease; new zealand ... See more keywords
Liver Directed Adeno-Associated Viral Vectors to Treat Metabolic Disease.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of inherited metabolic disease"
DOI: 10.1002/jimd.12637
Abstract: The liver is the metabolic center of the body and an ideal target for gene therapy of inherited metabolic disorders (IMDs). Adeno-associated viral (AAV) vectors can deliver transgenes to the liver with high efficiency and… read more here.
Keywords: adeno associated; gene therapy; metabolic disease; liver directed ... See more keywords
Leveraging the Gut to Treat Metabolic Disease.
Sign Up to like & getrecommendations! Published in 2020 at "Cell metabolism"
DOI: 10.1016/j.cmet.2020.02.014
Abstract: 25 years ago, the future of treating obesity and diabetes focused on end organs known to be involved in energy balance and glucose regulation, including the brain, muscle, adipose tissue, and pancreas. Today, the most… read more here.
Keywords: metabolic disease; treat metabolic; gut treat; leveraging gut ... See more keywords
Impaired cross-talk between NO and hyperpolarization in myoendothelial feedback: a novel therapeutic target in early endothelial dysfunction of metabolic disease.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in pharmacology"
DOI: 10.1016/j.coph.2019.03.007
Abstract: Over the past three decades, our view of the endothelium rapidly evolved from a static lining of the blood vessels to a dynamic determinant and regulator of vascular tone and homeostasis. It is now widely… read more here.
Keywords: hyperpolarization; metabolic disease; disease; function ... See more keywords
Redox Signals in Healthspan and Metabolic Disease
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.04.043
Abstract: Processing and intermediate metabolism of macronutrients are essential components of any life. Facultative or obligatory conversion of carbohydrates as well as fatty and amino acids into readily available energy equivalents like ATP are tightly regulated.… read more here.
Keywords: amino acids; metabolic disease; metabolism; redox signals ... See more keywords
How does PTSD treatment affect cardiovascular, diabetes and metabolic disease risk factors and outcomes? A systematic review.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of psychosomatic research"
DOI: 10.1016/j.jpsychores.2022.110793
Abstract: OBJECTIVE Prior research indicates PTSD is associated with cardiovascular and metabolic disease. A number of different treatments for PTSD can be effective in reducing PTSD symptoms. The aim of this study is to systematically review… read more here.
Keywords: risk; ptsd; disease; ptsd treatment ... See more keywords
NAFLD - A rising metabolic disease
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2021.101274
Abstract: The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing world wide, with nearly 1 billion people globally affected. This tremendous rise is related to the worldwide obesity and diabetes epidemics, which together represent a… read more here.
Keywords: metabolic disease; disease; liver; rising metabolic ... See more keywords
The shift work and health research agenda: Considering changes in gut microbiota as a pathway linking shift work, sleep loss and circadian misalignment, and metabolic disease.
Sign Up to like & getrecommendations! Published in 2017 at "Sleep medicine reviews"
DOI: 10.1016/j.smrv.2016.06.009
Abstract: Prevalence and impact of metabolic disease is rising. In particular, overweight and obesity are at epidemic levels and are a leading health concern in the Western world. Shift work increases the risk of overweight and… read more here.
Keywords: shift; metabolic disease; gut microbiota; shift work ... See more keywords
Genetic Profiling of Breast Cancer with and Without Preexisting Metabolic Disease
Sign Up to like & getrecommendations! Published in 2019 at "Translational Oncology"
DOI: 10.1016/j.tranon.2019.09.008
Abstract: Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death among women. Various mechanisms are involved in the initiation and progression of breast cancer. Metabolic dysregulation has been associated with… read more here.
Keywords: cancer; metabolic disease; preexisting metabolic; breast cancer ... See more keywords
Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23240-7
Abstract: Obesity is a major risk factor underlying the development of metabolic disease and a growing public health concern globally. Strategies to promote skeletal muscle metabolism can be effective to limit the progression of metabolic disease.… read more here.
Keywords: skeletal muscle; muscle; metabolic disease; yap regulates ... See more keywords