Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14465
Abstract: The prevalence of metabolic diseases, such as obesity, diabetes, metabolic syndrome and chronic liver diseases among others, has been rising for several years. Epidemiology and mechanistic (in vivo, in vitro and in silico) toxicology have recently provided compelling… read more here.
Keywords: combinatorial pathway; metabolic diseases; endocrine disruptors; disruption powerful ... See more keywords
Engineering Mammalian Designer Cells for the Treatment of Metabolic Diseases
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology Journal"
DOI: 10.1002/biot.201700160
Abstract: Synthetic biology applies engineering principles to biological systems and has significantly advanced the design of synthetic gene circuits that can reprogram cell activities to perform new functions. The ability to engineer mammalian designer cells with… read more here.
Keywords: designer; treatment metabolic; engineering; metabolic diseases ... See more keywords
Differences in the prevalence of cardiovascular and metabolic diseases coinciding with clinical subtypes of obstructive sleep apnea
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Cardiology"
DOI: 10.1002/clc.23941
Abstract: It is unclear about the cardiovascular and metabolic diseases (CMD) among Chinese patients with different clinical subtypes of obstructive sleep apnea (OSA). read more here.
Keywords: clinical subtypes; subtypes obstructive; cardiovascular metabolic; sleep apnea ... See more keywords
Significance of circulatory DPP4 activity in metabolic diseases
Sign Up to like & getrecommendations! Published in 2018 at "IUBMB Life"
DOI: 10.1002/iub.1709
Abstract: Dipeptidyl peptidase 4 (DPP4), also known as CD26 is a type II transmembrane protein that is released from the cell membrane in a nonclassical secretory mechanism. This exopeptidase selectively degrades varieties of substrates including incretin… read more here.
Keywords: dpp4; dpp4 activity; metabolic diseases; circulatory dpp4 ... See more keywords
Recent advances in the pathophysiology of inherited metabolic diseases
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Developmental Neuroscience"
DOI: 10.1002/jdn.10007
Abstract: Inborn errors of metabolism (IEM) are a group of rare genetic diseases caused by defects in different types of proteins, including enzymes, structural proteins or transporters. The blockage of a metabolic pathway leads to an… read more here.
Keywords: metabolic diseases; advances pathophysiology; inherited metabolic; pathophysiology inherited ... See more keywords
Choline‐related‐inherited metabolic diseases—A mini review
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12011
Abstract: In humans, the important water soluble, vitamin‐like nutrient choline, is taken up with the diet or recycled in the liver. Deficiencies of choline have only been reported in experimental situations or total parenteral nutrition. Currently,… read more here.
Keywords: mini review; choline; metabolic diseases; choline related ... See more keywords
Long‐term anthropometric development of individuals with inherited metabolic diseases identified by newborn screening
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12563
Abstract: Newborn screening (NBS) for inherited metabolic diseases (IMDs) substantially shortens a patient's journey. It enables the early start of metabolic treatment which might prevent potentially lethal neonatal disease manifestations, while promoting favorable development and long‐term… read more here.
Keywords: long term; development; sds; metabolic diseases ... See more keywords
Targeting ferroptosis in cardio‐metabolic‐diseases: Mechanisms and therapeutic prospects
Sign Up to like & getrecommendations! Published in 2023 at "Medicinal Research Reviews"
DOI: 10.1002/med.21934
Abstract: Cardio‐metabolic‐diseases (cardio‐metabolic‐diseases) are leading causes of death and disability worldwide and impose a tremendous burden on whole society as well as individuals. As a new type of regulated cell death (RCD), ferroptosis is distinct from… read more here.
Keywords: targeting ferroptosis; metabolic diseases; cardio metabolic;
Risks of metabolic diseases and androgen deprivation therapy for prostate cancer in a Chinese population: a prospective multi-centre cohort study
Sign Up to like & getrecommendations! Published in 2022 at "International Urology and Nephrology"
DOI: 10.1007/s11255-022-03151-2
Abstract: Androgen deprivation therapy (ADT) use in prostate cancer (PCa) has seen a rising trend. We are looking into the relationship between ADT and development of metabolic diseases in Chinese patients. This is a prospective multi-centre… read more here.
Keywords: deprivation therapy; androgen deprivation; prospective multi; metabolic diseases ... See more keywords
[Acute liver failure related to inherited metabolic diseases in young children].
Sign Up to like & getrecommendations! Published in 2018 at "Anales de pediatria"
DOI: 10.1016/j.anpedi.2017.02.012
Abstract: INTRODUCTION Pediatric acute liver failure (ALF) due to inherited metabolic diseases (IMD) is a rare life-threatening condition with a poor prognosis. Early intervention may be lifesaving. OBJECTIVE To describe clinical presentation, investigation and outcomes of… read more here.
Keywords: liver failure; metabolic diseases; acute liver; inherited metabolic ... See more keywords
The cGAS–STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy
Sign Up to like & getrecommendations! Published in 2021 at "Acta Pharmaceutica Sinica B"
DOI: 10.1016/j.apsb.2021.05.011
Abstract: Abstract The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling exert essential regulatory function in microbial-and onco-immunology through the induction of cytokines, primarily type I interferons. Recently, the aberrant and deranged signaling of the… read more here.
Keywords: cardiovascular metabolic; metabolic diseases; signaling cardiovascular; sting signaling ... See more keywords