Hepatocellular Carcinoma in Metabolic Dysfunction-Associated Steatotic Liver Disease
Sign Up to like & getrecommendations! Published in 2024 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2024.21019
Abstract: Key Points Question In patients with metabolic dysfunction–associated steatotic liver disease (MASLD), can those at high risk of developing hepatocellular carcinoma (HCC) be identified? Findings This prognostic study used electronic health record data from 1 811 461… read more here.
Keywords: steatotic liver; dysfunction associated; hepatocellular carcinoma; liver disease ... See more keywords
Value-Based Pricing of Resmetirom for Metabolic Dysfunction–Associated Steatotic Liver Disease
Sign Up to like & getrecommendations! Published in 2025 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2025.17122
Abstract: Key Points Question Compared with standard of care, is resmetirom cost-effective in treating metabolic dysfunction–associated steatohepatitis and significant fibrosis among US adults in a simulated cohort? Findings In this economic evaluation, at a price of… read more here.
Keywords: resmetirom; value based; dysfunction associated; metabolic dysfunction ... See more keywords
CD146 Associates with Gp130 to Control a Macrophage Pro‐inflammatory Program That Regulates the Metabolic Response to Obesity
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202103719
Abstract: The mechanism of obesity‐related metabolic dysfunction involves the development of systemic inflammation, largely mediated by macrophages. Switching of M1‐like adipose tissue macrophages (ATMs) to M2‐like ATMs, a population of macrophages associated with weight loss and… read more here.
Keywords: cd146; pro inflammatory; polarization; obesity ... See more keywords
Paternal Obesity‐Induced H3K27me3 Elevation Leads to MANF‐Mediated Transgenerational Metabolic Dysfunction in Female Offspring
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DOI: 10.1002/advs.202415956
Abstract: Paternal lifestyle and environmental exposures can alter epigenetic changes in sperm and play a critical role in the offspring's future health, yet the underlying mechanisms remain elusive. The present study established a model of paternal… read more here.
Keywords: paternal obesity; female offspring; transgenerational metabolic; dysfunction ... See more keywords
Metabolic Dysfunction in New‐Onset Idiopathic Intracranial Hypertension: Identification of Novel Biomarkers
Sign Up to like & getrecommendations! Published in 2024 at "Annals of Neurology"
DOI: 10.1002/ana.27010
Abstract: Idiopathic intracranial hypertension (IIH) is a neurometabolic disease with an increasing incidence. The pathophysiology is unknown, but improvement of diagnosis and management requires discovery of novel biomarkers. Our objective was to identify such candidate biomarkers… read more here.
Keywords: intracranial hypertension; novel biomarkers; idiopathic intracranial; dysfunction new ... See more keywords
Effects of Metabolic Dysfunction–Associated Steatohepatitis in Alertness, Associative Learning, and Astrocyte Density
Sign Up to like & getrecommendations! Published in 2024 at "Brain and Behavior"
DOI: 10.1002/brb3.70222
Abstract: Metabolic dysfunction–associated steatohepatitis (MASH) is a prevalent disease caused by high fat and high cholesterol intake, which leads to systemic deterioration. The aim of this research is to conduct a psychobiological exploration of MASH in… read more here.
Keywords: associated steatohepatitis; effects metabolic; dysfunction associated; metabolic dysfunction ... See more keywords
Paying the Iron Price: Liver Iron Homeostasis and Metabolic Disease.
Sign Up to like & getrecommendations! Published in 2022 at "Comprehensive Physiology"
DOI: 10.1002/cphy.c210039
Abstract: Iron is an essential metal element whose bioavailability is tightly regulated. Under normal conditions, systemic and cellular iron homeostases are synchronized for optimal function, based on the needs of each system. During metabolic dysfunction, this… read more here.
Keywords: iron; iron homeostasis; homeostasis metabolic; metabolic dysfunction ... See more keywords
Non‐invasive assessment of hepatic steatosis by ultrasound‐derived fat fraction in individuals at high‐risk for metabolic dysfunction‐associated steatotic liver disease
Sign Up to like & getrecommendations! Published in 2024 at "Diabetes/Metabolism Research and Reviews"
DOI: 10.1002/dmrr.3787
Abstract: Given the increasing number of individuals developing metabolic dysfunction‐associated steatotic liver disease (MASLD) and the low rate of those with progressive liver disease, there is a pressing need to conceive affordable biomarkers to assess MASLD… read more here.
Keywords: dysfunction associated; liver disease; metabolic dysfunction; liver ... See more keywords
Incident heart failure is common and underrecognized in patients with biopsy-proven metabolic dysfunction-associated steatotic liver disease.
Sign Up to like & getrecommendations! Published in 2025 at "European journal of heart failure"
DOI: 10.1002/ejhf.3697
Abstract: Metabolic dysfunction‐associated steatotic liver disease (MASLD) is associated with heart failure (HF), independent of shared risk factors. Our aim was to describe the incidence of HF in patients with biopsy‐proven MASLD. read more here.
Keywords: heart; dysfunction associated; heart failure; metabolic dysfunction ... See more keywords
Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32647
Abstract: Background and Aim: Injury to hepatocyte mitochondria is common in metabolic dysfunction‐associated fatty liver disease. Here, we investigated whether changes in the content of essential fatty acid–derived lipid autacoids affect hepatocyte mitochondrial bioenergetics and metabolic… read more here.
Keywords: mice; efficiency; fat mice; lipid autacoids ... See more keywords
The tumor microenvironment drives NK cell metabolic dysfunction leading to impaired antitumor activity
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DOI: 10.1002/ijc.34389
Abstract: NK cells represent key players capable of driving antitumor immune responses. However, the potent immunosuppressive activity of the tumor microenvironment (TME) may impair their effector function. Here, we strengthen the importance of metabolic interactions between… read more here.
Keywords: activity; antitumor; tumor microenvironment; metabolic dysfunction ... See more keywords