CD146 Associates with Gp130 to Control a Macrophage Pro‐inflammatory Program That Regulates the Metabolic Response to Obesity
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202103719
Abstract: The mechanism of obesity‐related metabolic dysfunction involves the development of systemic inflammation, largely mediated by macrophages. Switching of M1‐like adipose tissue macrophages (ATMs) to M2‐like ATMs, a population of macrophages associated with weight loss and… read more here.
Keywords: cd146; pro inflammatory; polarization; obesity ... See more keywords
Paying the Iron Price: Liver Iron Homeostasis and Metabolic Disease.
Sign Up to like & getrecommendations! Published in 2022 at "Comprehensive Physiology"
DOI: 10.1002/cphy.c210039
Abstract: Iron is an essential metal element whose bioavailability is tightly regulated. Under normal conditions, systemic and cellular iron homeostases are synchronized for optimal function, based on the needs of each system. During metabolic dysfunction, this… read more here.
Keywords: iron; iron homeostasis; homeostasis metabolic; metabolic dysfunction ... See more keywords
Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32647
Abstract: Background and Aim: Injury to hepatocyte mitochondria is common in metabolic dysfunction‐associated fatty liver disease. Here, we investigated whether changes in the content of essential fatty acid–derived lipid autacoids affect hepatocyte mitochondrial bioenergetics and metabolic… read more here.
Keywords: mice; efficiency; fat mice; lipid autacoids ... See more keywords
The tumor microenvironment drives NK cell metabolic dysfunction leading to impaired antitumor activity
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34389
Abstract: NK cells represent key players capable of driving antitumor immune responses. However, the potent immunosuppressive activity of the tumor microenvironment (TME) may impair their effector function. Here, we strengthen the importance of metabolic interactions between… read more here.
Keywords: activity; antitumor; tumor microenvironment; metabolic dysfunction ... See more keywords
Risk stratification using sarcopenia status among subjects with metabolic dysfunction‐associated fatty liver disease
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.12754
Abstract: Sarcopenia is a significant indicator of the severity of non‐alcoholic fatty liver disease. We investigated whether sarcopenia could identify subgroups with different risk of liver fibrosis and atherosclerotic cardiovascular disease (ASCVD) among subjects with metabolic… read more here.
Keywords: subjects metabolic; fatty liver; among subjects; metabolic dysfunction ... See more keywords
Irisin ameliorates age‐associated sarcopenia and metabolic dysfunction
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13141
Abstract: Age‐associated sarcopenia is characterized of progressed loss of skeletal muscle power, mass, and function, which affects human physical activity and life quality. Besides, accompanied with sarcopenia, aged population also faces a series of metabolic dysfunctions.… read more here.
Keywords: associated sarcopenia; metabolic dysfunction; age associated; sarcopenia metabolic ... See more keywords
Obesity and metabolic dysfunction correlate with background parenchymal enhancement in premenopausal women
Sign Up to like & getrecommendations! Published in 2023 at "Obesity"
DOI: 10.1002/oby.23649
Abstract: This study tested the hypothesis that obesity and metabolic abnormalities correlate with background parenchymal enhancement (BPE), the volume and intensity of enhancing fibroglandular breast tissue on dynamic contrast‐enhanced magnetic resonance imaging. read more here.
Keywords: dysfunction correlate; parenchymal enhancement; correlate background; obesity metabolic ... See more keywords
Emerging therapies: The potential roles SGLT2 inhibitors, GLP1 agonists, and ARNI therapy for ARNI pulmonary hypertension
Sign Up to like & getrecommendations! Published in 2022 at "Pulmonary Circulation"
DOI: 10.1002/pul2.12028
Abstract: Abstract Pulmonary hypertension (PH) is a highly morbid condition. PH due to left heart disease (PH‐LHD) has no specific therapies and pulmonary arterial hypertension (PAH) has substantial residual risk despite several approved therapies. Multiple lines… read more here.
Keywords: pulmonary hypertension; inhibitors glp1; sglt2 inhibitors; glp1 agonists ... See more keywords
Cholecystectomy as a risk factor for metabolic dysfunction-associated fatty liver disease: unveiling the metabolic and chronobiologic clues behind the bile acid enterohepatic circulation.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of physiology and biochemistry"
DOI: 10.1007/s13105-020-00782-w
Abstract: Metabolic dysfunction-associated fatty liver disease (MAFLD) is highly prevalent worldwide. Recent clinical and experimental studies have addressed the association between cholecystectomy and MAFLD, confirming that cholecystectomy is an independent risk factor for MAFLD. In this… read more here.
Keywords: fatty liver; liver disease; associated fatty; dysfunction associated ... See more keywords
The effects of oxytocin to rectify metabolic dysfunction in obese mice are associated with increased thermogenesis
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2020.110903
Abstract: Oxytocin, a protein hormone mainly produced by hypothalamus, has been shown to repress body weight gain in obese animals, in part, by reducing food intake and increasing energy expenditure. Till now, activation of brown fat… read more here.
Keywords: rectify metabolic; obese mice; effects oxytocin; oxytocin rectify ... See more keywords
SUMOylation of Enzymes and Ion Channels in Sensory Neurons Protects against Metabolic Dysfunction, Neuropathy, and Sensory Loss in Diabetes
Sign Up to like & getrecommendations! Published in 2020 at "Neuron"
DOI: 10.1016/j.neuron.2020.06.037
Abstract: Diabetic peripheral neuropathy (DPN) is a highly frequent and debilitating clinical complication of diabetes that lacks therapies. Cellular oxidative stress regulates post-translational modifications, including SUMOylation. Here, using unbiased screens, we identified key enzymes in metabolic… read more here.
Keywords: sumoylation; ion channels; sensory loss; sensory neurons ... See more keywords