Metformin attenuates antipsychotic-induced metabolic dysfunctions in MK801-induced schizophrenia-like rats
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05524-w
Abstract: Rationale Second-generation antipsychotics are the first-line medications prescribed for schizophrenic patients; however, some of them, such as olanzapine and risperidone, may induce metabolic dysfunctions during short-term treatment. Metformin is an effective adjuvant that attenuates antipsychotic-induced… read more here.
Keywords: schizophrenia like; mk801 induced; olanzapine risperidone; metabolic dysfunctions ... See more keywords
Development of Novel IP6K Inhibitors for the Treatment of Obesity and Obesity-Induced Metabolic Dysfunctions.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00220
Abstract: Obesity and obesity-induced metabolic dysfunctions are significant risk factors for nonalcoholic fatty liver disease and cardiovascular diseases. Thus, obesity is an economic and social burden in developed countries. Blocking the synthesis of inositol pyrophosphates by… read more here.
Keywords: obesity; obesity induced; obesity obesity; metabolic dysfunctions ... See more keywords
The PD-1/PD-L1 axis contributes to immune metabolic dysfunctions of monocytes in chronic lymphocytic leukemia
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DOI: 10.1038/leu.2016.214
Abstract: Immune dysfunctions in chronic lymphocytic leukemia (CLL) contribute to tumor immune escape and attenuate immune-based therapies. Monocytes/macrophages represent key components of cancer immune surveillance and effectors for antibody-mediated antitumor effects. Monocytes display an altered subset… read more here.
Keywords: immune metabolic; cll; lymphocytic leukemia; metabolic dysfunctions ... See more keywords
Excessive Glucocorticoids During Pregnancy Impair Fetal Brown Fat Development and Predispose Offspring to Metabolic Dysfunctions
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DOI: 10.2337/db20-0009
Abstract: Maternal stress during pregnancy exposes fetuses to hyperglucocorticoids, which increases the risk of metabolic dysfunctions in offspring. Despite being a key tissue for maintaining metabolic health, the impacts of maternal excessive glucocorticoids (GC) on fetal… read more here.
Keywords: pregnancy; bat; fetal brown; metabolic dysfunctions ... See more keywords