Model-Guided Systematic Metabolic Engineering for Enhanced Spinosad Biosynthesis in Saccharopolyspora spinosa NHF132.
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DOI: 10.1002/advs.202511411
Abstract: Spinosad (a mixture of spinosyns A and D) is a macrocyclic lactone green bioinsecticide produced by Saccharopolyspora spinosa. It is known for its high efficiency, low toxicity, and broad‐spectrum activity. Although numerous strategies have been… read more here.
Keywords: spinosa nhf132; engineering; saccharopolyspora spinosa; metabolic engineering ... See more keywords
Metabolic Engineering of Corynebacterium glutamicum for High‐Level Production of 1,5‐Pentanediol, a C5 Diol Platform Chemical (Adv. Sci. 13/2025)
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DOI: 10.1002/advs.202570090
Abstract: Metabolic Engineering of Corynebacterium glutamicum In article number 2412670, Jeong Chan Joo, Jin‐Byung Park, Si Jae Park, and co‐workers highlight the development of a metabolically engineered Corynebacterium glutamicum for sustainable production of 1,5‐pentanediol via a… read more here.
Keywords: engineering corynebacterium; corynebacterium glutamicum; metabolic engineering;
Metabolic Engineering for Advanced Biofuels Production and Recent Advances Toward Commercialization
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DOI: 10.1002/biot.201600433
Abstract: Research on renewable biofuels produced by microorganisms has enjoyed considerable advances in academic and industrial settings. As the renewable ethanol market approaches maturity, the demand is rising for the commercialization of more energy‐dense fuel targets.… read more here.
Keywords: production; metabolic engineering; engineering advanced; commercialization ... See more keywords
Advancing Metabolic Engineering of Saccharomyces cerevisiae Using the CRISPR/Cas System
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DOI: 10.1002/biot.201700601
Abstract: Thanks to its ease of use, modularity, and scalability, the clustered regularly interspaced short palindromic repeats (CRISPR) system has been increasingly used in the design and engineering of Saccharomyces cerevisiae, one of the most popular… read more here.
Keywords: engineering; saccharomyces cerevisiae; crispr; system ... See more keywords
Synthetic Biology Toolkits for Metabolic Engineering of Cyanobacteria
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DOI: 10.1002/biot.201800496
Abstract: Cyanobacteria are of great importance to Earth's ecology. Due to their capability in photosynthesis and C1 metabolism, they are ideal microbial chassis that can be engineered for direct conversion of carbon dioxide and solar energy… read more here.
Keywords: metabolic engineering; synthetic biology; biology toolkits; biology ... See more keywords
Metabolic Engineering Strategies for the Enhanced Microalgal Production of Long-Chain Polyunsaturated Fatty Acids (LC-PUFAs).
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DOI: 10.1002/biot.201900043
Abstract: Long-chain polyunsaturated fatty acids (LC-PUFAs), largely obtained from fish oil, serve as valuable dietary supplements with many health benefits, especially arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid. In recent years, interest in the sustainable production… read more here.
Keywords: engineering; production; metabolic engineering; fatty acids ... See more keywords
Systems Metabolic Engineering Approaches for Rewiring Cells
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DOI: 10.1002/biot.201900312
Abstract: The field of systems metabolic engineering is rapidly expanding, thanks to impressive improvements in both ‘omics measurements and computational frameworks. This general systems‐level paradigm is enabling new applications beyond just chemical overproduction. This special issue—inspired… read more here.
Keywords: metabolic engineering; engineering; https doi; 1002 biot ... See more keywords
Metabolic engineering of Aspergillus niger for accelerated malic acid biosynthesis by improving NADPH availability
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DOI: 10.1002/biot.202400014
Abstract: Microbial production of L‐malic acid from renewable carbon sources has attracted extensive attention. The reduced cofactor NADPH plays a key role in biotransformation because it participates in both biosynthetic reactions and cellular stress responses. In… read more here.
Keywords: metabolic engineering; malic acid; aspergillus niger;
Metabolic engineering of Methanosarcina acetivorans for lactate production from methane
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DOI: 10.1002/bit.26208
Abstract: We previously demonstrated anaerobic conversion of the greenhouse gas methane into acetate using an engineered archaeon that produces methyl‐coenzyme M reductase (Mcr) from unculturable microorganisms from a microbial mat in the Black Sea to create… read more here.
Keywords: methane; metabolic engineering; lactate production;
Metabolic engineering of isopropyl alcohol‐producing Escherichia coli strains with 13C‐metabolic flux analysis
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DOI: 10.1002/bit.26390
Abstract: Metabolic engineering of isopropyl alcohol (IPA)‐producing Escherichia coli strains was conducted along with 13C‐metabolic flux analysis (MFA). A metabolically engineered E. coli strain expressing the adc gene derived from Clostridium acetobutylicum and the IPADH gene… read more here.
Keywords: metabolic engineering; flux; isopropyl alcohol; coli ... See more keywords
CRISPR interference-mediated metabolic engineering of Corynebacterium glutamicum for homo-butyrate production.
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DOI: 10.1002/bit.26720
Abstract: Combinatorial metabolic engineering enabled the development of efficient microbial cell factories for modulating gene expression to produce desired products. Here, we report the combinatorial metabolic engineering of Corynebacterium glutamicum to produce butyrate by introducing a… read more here.
Keywords: production; butyrate; metabolic engineering; glutamicum ... See more keywords