Metabolic Engineering for Advanced Biofuels Production and Recent Advances Toward Commercialization
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DOI: 10.1002/biot.201600433
Abstract: Research on renewable biofuels produced by microorganisms has enjoyed considerable advances in academic and industrial settings. As the renewable ethanol market approaches maturity, the demand is rising for the commercialization of more energy‐dense fuel targets.… read more here.
Keywords: production; metabolic engineering; engineering advanced; commercialization ... See more keywords
Advancing Metabolic Engineering of Saccharomyces cerevisiae Using the CRISPR/Cas System
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DOI: 10.1002/biot.201700601
Abstract: Thanks to its ease of use, modularity, and scalability, the clustered regularly interspaced short palindromic repeats (CRISPR) system has been increasingly used in the design and engineering of Saccharomyces cerevisiae, one of the most popular… read more here.
Keywords: engineering; saccharomyces cerevisiae; crispr; system ... See more keywords
Synthetic Biology Toolkits for Metabolic Engineering of Cyanobacteria
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DOI: 10.1002/biot.201800496
Abstract: Cyanobacteria are of great importance to Earth's ecology. Due to their capability in photosynthesis and C1 metabolism, they are ideal microbial chassis that can be engineered for direct conversion of carbon dioxide and solar energy… read more here.
Keywords: metabolic engineering; synthetic biology; biology toolkits; biology ... See more keywords
Metabolic Engineering Strategies for the Enhanced Microalgal Production of Long-Chain Polyunsaturated Fatty Acids (LC-PUFAs).
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DOI: 10.1002/biot.201900043
Abstract: Long-chain polyunsaturated fatty acids (LC-PUFAs), largely obtained from fish oil, serve as valuable dietary supplements with many health benefits, especially arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid. In recent years, interest in the sustainable production… read more here.
Keywords: engineering; production; metabolic engineering; fatty acids ... See more keywords
Systems Metabolic Engineering Approaches for Rewiring Cells
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DOI: 10.1002/biot.201900312
Abstract: The field of systems metabolic engineering is rapidly expanding, thanks to impressive improvements in both ‘omics measurements and computational frameworks. This general systems‐level paradigm is enabling new applications beyond just chemical overproduction. This special issue—inspired… read more here.
Keywords: metabolic engineering; engineering; https doi; 1002 biot ... See more keywords
Metabolic engineering of Methanosarcina acetivorans for lactate production from methane
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DOI: 10.1002/bit.26208
Abstract: We previously demonstrated anaerobic conversion of the greenhouse gas methane into acetate using an engineered archaeon that produces methyl‐coenzyme M reductase (Mcr) from unculturable microorganisms from a microbial mat in the Black Sea to create… read more here.
Keywords: methane; metabolic engineering; lactate production;
Metabolic engineering of isopropyl alcohol‐producing Escherichia coli strains with 13C‐metabolic flux analysis
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DOI: 10.1002/bit.26390
Abstract: Metabolic engineering of isopropyl alcohol (IPA)‐producing Escherichia coli strains was conducted along with 13C‐metabolic flux analysis (MFA). A metabolically engineered E. coli strain expressing the adc gene derived from Clostridium acetobutylicum and the IPADH gene… read more here.
Keywords: metabolic engineering; flux; isopropyl alcohol; coli ... See more keywords
CRISPR interference-mediated metabolic engineering of Corynebacterium glutamicum for homo-butyrate production.
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DOI: 10.1002/bit.26720
Abstract: Combinatorial metabolic engineering enabled the development of efficient microbial cell factories for modulating gene expression to produce desired products. Here, we report the combinatorial metabolic engineering of Corynebacterium glutamicum to produce butyrate by introducing a… read more here.
Keywords: production; butyrate; metabolic engineering; glutamicum ... See more keywords
Rational design of thiolase substrate specificity for metabolic engineering applications
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DOI: 10.1002/bit.26737
Abstract: Metabolic engineering efforts require enzymes that are both highly active and specific toward the synthesis of a desired output product to be commercially feasible. The 3‐hydroxyacid (3HA) pathway, also known as the reverse β‐oxidation or… read more here.
Keywords: chain; metabolic engineering; thiolase; thiolase substrate ... See more keywords
Pareto Optimal Metabolic Engineering for the Growth-coupled Overproduction of Sustainable Chemicals.
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DOI: 10.1002/bit.28103
Abstract: Our research aims to help industrial biotechnology develop a sustainable economy using green technology based on microorganisms and synthetic biology through two case studies that improve metabolic capacity in yeast models Yarrowia lipolytica (Y. lipolytica)… read more here.
Keywords: optimal metabolic; growth; engineering growth; pareto optimal ... See more keywords
Systems metabolic engineering of Streptomyces venezuelae for the enhanced production of pikromycin
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DOI: 10.1002/bit.28114
Abstract: Pikromycin is an important precursor of drugs, for example, erythromycin. Hence, systems metabolic engineering for the enhanced pikromycin production can contribute to the development of pikromycin‐related drugs. In this study, metabolic genes in Streptomyces venezuelae… read more here.
Keywords: metabolic engineering; systems metabolic; pikromycin; production ... See more keywords