Synthesis, characterization, molecular docking, and biological activities of coumarin–1,2,3‐triazole‐acetamide hybrid derivatives
Sign Up to like & getrecommendations! Published in 2020 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202000109
Abstract: Coumarins and their derivatives are receiving increasing attention due to numerous biochemical and pharmacological applications. In this study, a series of novel coumarin–1,2,3‐triazole‐acetamide hybrids was tested against some metabolic enzymes including α‐glycosidase (α‐Gly), α‐amylase (α‐Amy),… read more here.
Keywords: coumarin triazole; triazole acetamide; acetamide hybrids; metabolic enzymes ... See more keywords
Synthesis and biological studies of pyrimidine derivatives targeting metabolic enzymes
Sign Up to like & getrecommendations! Published in 2024 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202300634
Abstract: Novel synthesized pyrimidine derivatives were investigated against carbonic anhydrase isoenzymes I and II (hCA I and II), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), α‐glycosidase, and aldose reductase (AR) enzymes associated with some common diseases such as epilepsy,… read more here.
Keywords: synthesized pyrimidine; pyrimidine derivatives; metabolic enzymes; synthesis biological ... See more keywords
Therapeutic targets of vitamin D receptor ligands and their pharmacokinetic effects by modulation of transporters and metabolic enzymes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pharmaceutical Investigation"
DOI: 10.1007/s40005-019-00429-z
Abstract: Vitamin D is involved in retaining the balance of several minerals in the body, such as calcium and phosphate, which are crucial for the bone formation and development. These physiological effects of vitamin D are… read more here.
Keywords: transporters metabolic; vitamin receptor; targets vitamin; therapeutic targets ... See more keywords
Analyzing the hepatoprotective effect of the Swertia cincta Burkillextract against ANIT-induced cholestasis in rats by modulating the expression of transporters and metabolic enzymes.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2017.07.031
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Swertia cincta Burkill was traditionally used for treating jaundice and various types of chronic and acute hepatitis in Yunnan and Tibet in China for hundreds of years. This study aims to investigate the… read more here.
Keywords: transporters metabolic; pathology; expression; metabolic enzymes ... See more keywords
Secondary Metabolic Potential of Kutzneria.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.3c00007
Abstract: Kutzneria is a rare genus of Actinobacteria that harbors a variety of secondary metabolite gene clusters and produces several interesting types of bioactive secondary metabolites. Recent efforts have partially elucidated the biosynthetic pathways of some… read more here.
Keywords: kutzneria; metabolic potential; natural products; metabolic enzymes ... See more keywords
Anchorless Bacterial Moonlighting Metabolic Enzymes Modulate the Immune System and Contribute to Pathogenesis.
Sign Up to like & getrecommendations! Published in 2024 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.4c00323
Abstract: Moonlighting proteins (MPs), characterized by their ability to perform multiple physiologically unrelated functions without alterations to their primary structures, represent a fascinating class of biomolecules with significant implications for host-pathogen interactions. This Review highlights the… read more here.
Keywords: bacterial moonlighting; anchorless bacterial; moonlighting metabolic; metabolic enzymes ... See more keywords
Nuclear localization of MTHFD2 is required for correct mitosis progression
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-51847-z
Abstract: Subcellular compartmentalization of metabolic enzymes establishes a unique metabolic environment that elicits specific cellular functions. Indeed, the nuclear translocation of certain metabolic enzymes is required for epigenetic regulation and gene expression control. Here, we show… read more here.
Keywords: metabolic enzymes; progression; mitosis; nuclear localization ... See more keywords
Differential genotoxicity of Polygoni Multiflori in rat and human: insights from Ames test and S9 metabolic activation system
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-72283-5
Abstract: The Ames test is used worldwide to initially screen the mutagenic potential of new chemicals. In the standard Ames test, S. typhimurium strains (TA100, TA98, TA1535, and TA1537) and Escherichia coli (WP2uvrA) are treated with… read more here.
Keywords: ames test; rat human; metabolic enzymes; polygoni multiflori ... See more keywords
Human mass balance, pharmacokinetics and metabolism of rovatirelin and identification of its metabolic enzymes in vitro
Sign Up to like & getrecommendations! Published in 2019 at "Xenobiotica"
DOI: 10.1080/00498254.2019.1580796
Abstract: Abstract The mass balance, pharmacokinetics and metabolism of rovatirelin were characterised in healthy male subjects after a single oral dose of [14C]rovatirelin. [14C]Rovatirelin was steadily absorbed, and the peak concentrations of radioactivity and rovatirelin were… read more here.
Keywords: balance pharmacokinetics; rovatirelin; mass balance; metabolic enzymes ... See more keywords
An update on sugar allocation and accumulation in fruits.
Sign Up to like & getrecommendations! Published in 2023 at "Plant physiology"
DOI: 10.1093/plphys/kiad294
Abstract: Fruit sweetness is determined by the amount and composition of sugars in the edible flesh. The accumulation of sugar is a highly orchestrated process that requires coordination of numerous metabolic enzymes and sugar transporters. This… read more here.
Keywords: metabolic enzymes; fruit; accumulation; sugar allocation ... See more keywords
The metabolomic landscape plays a critical role in glioma oncogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15325
Abstract: Cancer cells depend on metabolic reprogramming for survival, undergoing profound shifts in nutrient sensing, nutrient uptake and flux through anabolic pathways, in order to drive nucleotide, lipid, and protein synthesis and provide key intermediates needed… read more here.
Keywords: metabolic enzymes; critical role; landscape plays; metabolomic landscape ... See more keywords