Synthesis, characterization, molecular docking, and biological activities of coumarin–1,2,3‐triazole‐acetamide hybrid derivatives
Sign Up to like & getrecommendations! Published in 2020 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202000109
Abstract: Coumarins and their derivatives are receiving increasing attention due to numerous biochemical and pharmacological applications. In this study, a series of novel coumarin–1,2,3‐triazole‐acetamide hybrids was tested against some metabolic enzymes including α‐glycosidase (α‐Gly), α‐amylase (α‐Amy),… read more here.
Keywords: coumarin triazole; triazole acetamide; acetamide hybrids; metabolic enzymes ... See more keywords
Therapeutic targets of vitamin D receptor ligands and their pharmacokinetic effects by modulation of transporters and metabolic enzymes
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DOI: 10.1007/s40005-019-00429-z
Abstract: Vitamin D is involved in retaining the balance of several minerals in the body, such as calcium and phosphate, which are crucial for the bone formation and development. These physiological effects of vitamin D are… read more here.
Keywords: transporters metabolic; vitamin receptor; targets vitamin; therapeutic targets ... See more keywords
Analyzing the hepatoprotective effect of the Swertia cincta Burkillextract against ANIT-induced cholestasis in rats by modulating the expression of transporters and metabolic enzymes.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2017.07.031
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Swertia cincta Burkill was traditionally used for treating jaundice and various types of chronic and acute hepatitis in Yunnan and Tibet in China for hundreds of years. This study aims to investigate the… read more here.
Keywords: transporters metabolic; pathology; expression; metabolic enzymes ... See more keywords
Secondary Metabolic Potential of Kutzneria.
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DOI: 10.1021/acs.jnatprod.3c00007
Abstract: Kutzneria is a rare genus of Actinobacteria that harbors a variety of secondary metabolite gene clusters and produces several interesting types of bioactive secondary metabolites. Recent efforts have partially elucidated the biosynthetic pathways of some… read more here.
Keywords: kutzneria; metabolic potential; natural products; metabolic enzymes ... See more keywords
Human mass balance, pharmacokinetics and metabolism of rovatirelin and identification of its metabolic enzymes in vitro
Sign Up to like & getrecommendations! Published in 2019 at "Xenobiotica"
DOI: 10.1080/00498254.2019.1580796
Abstract: Abstract The mass balance, pharmacokinetics and metabolism of rovatirelin were characterised in healthy male subjects after a single oral dose of [14C]rovatirelin. [14C]Rovatirelin was steadily absorbed, and the peak concentrations of radioactivity and rovatirelin were… read more here.
Keywords: balance pharmacokinetics; rovatirelin; mass balance; metabolic enzymes ... See more keywords
An update on sugar allocation and accumulation in fruits.
Sign Up to like & getrecommendations! Published in 2023 at "Plant physiology"
DOI: 10.1093/plphys/kiad294
Abstract: Fruit sweetness is determined by the amount and composition of sugars in the edible flesh. The accumulation of sugar is a highly orchestrated process that requires coordination of numerous metabolic enzymes and sugar transporters. This… read more here.
Keywords: metabolic enzymes; fruit; accumulation; sugar allocation ... See more keywords
The metabolomic landscape plays a critical role in glioma oncogenesis
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DOI: 10.1111/cas.15325
Abstract: Cancer cells depend on metabolic reprogramming for survival, undergoing profound shifts in nutrient sensing, nutrient uptake and flux through anabolic pathways, in order to drive nucleotide, lipid, and protein synthesis and provide key intermediates needed… read more here.
Keywords: metabolic enzymes; critical role; landscape plays; metabolomic landscape ... See more keywords
Phosphorylation of lipid metabolic enzymes by yeast protein kinase C requires phosphatidylserine and diacylglycerol
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Lipid Research"
DOI: 10.1194/jlr.m075036
Abstract: Protein kinase C in Saccharomyces cerevisiae, i.e., Pkc1, is an enzyme that plays an important role in signal transduction and the regulation of lipid metabolic enzymes. Pkc1 is structurally similar to its counterparts in higher… read more here.
Keywords: protein kinase; metabolic enzymes; lipid metabolic; phosphatidylserine diacylglycerol ... See more keywords
The mutual interaction of glycolytic enzymes and RNA in post-transcriptional regulation
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DOI: 10.1261/rna.079210.122
Abstract: About three decades ago, researchers suggested that metabolic enzymes participate in cellular processes that are unrelated to their catalytic activity, and the term “moonlighting functions” was proposed. Recently developed advanced technologies in the field of… read more here.
Keywords: rna binding; metabolic enzymes; transcriptional regulation; regulation ... See more keywords
Conserved metabolic enzymes as vaccine antigens for giardiasis
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0010323
Abstract: Giardia lamblia is a leading protozoal cause of diarrheal disease worldwide. Infection is associated with abdominal pain, malabsorption and weight loss, and protracted post-infectious syndromes. A human vaccine is not available against G. lamblia. Prior… read more here.
Keywords: immunization; conserved metabolic; metabolic enzymes; vaccine antigens ... See more keywords
Metabolic enzymes in glial cells of the honeybee brain and their associations with aging, starvation and food response
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DOI: 10.1371/journal.pone.0198322
Abstract: The honey bee has been extensively studied as a model for neuronal circuit and memory function and more recently has emerged as an unconventional model in biogerontology. Yet, the detailed knowledge of neuronal processing in… read more here.
Keywords: starvation; glial cells; food response; metabolic enzymes ... See more keywords