Metabolic and epigenetic regulation of endoderm differentiation.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2021.09.002
Abstract: The endoderm, one of the three primary germ layers, gives rise to lung, liver, stomach, intestine, colon, pancreas, bladder, and thyroid. These endoderm-originated organs are subject to many life-threatening diseases. However, primary cells/tissues from endodermal… read more here.
Keywords: endoderm differentiation; regulation endoderm; metabolic epigenetic; differentiation ... See more keywords
Circles of Life: linking metabolic and epigenetic cycles to immunity
Sign Up to like & getrecommendations! Published in 2020 at "Immunology"
DOI: 10.1111/imm.13207
Abstract: Metabolites are the essential substrates for epigenetic modification enzymes to write or erase the epigenetic blueprint in cells. Hence, the availability of nutrients and activity of metabolic pathways strongly influence the enzymatic function. Recent studies… read more here.
Keywords: circles life; metabolic epigenetic; life linking; linking metabolic ... See more keywords
Food for thought
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.abb4367
Abstract: The nuclear metabolic-epigenetic axis bridges the environment and genes to modulate behavior To drive behaviors essential for survival, numerous pathways have evolved that translate environmental stimuli into gene expression. These include interactions between metabolic and… read more here.
Keywords: expression; metabolic epigenetic; food thought;
Lactate rewires lipid metabolism and sustains a metabolic-epigenetic axis in prostate cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-21-0914
Abstract: Lactate is an abundant oncometabolite in the tumor environment. In prostate cancer (PCa), cancer-associated fibroblasts are major contributors of secreted lactate, which can be taken up by cancer cells to sustain mitochondrial metabolism. However, how… read more here.
Keywords: metabolic epigenetic; prostate cancer; lipid metabolism; cancer ... See more keywords
Metabolic and epigenetic dysfunctions underlie the arrest of in vitro fertilized human embryos in a senescent-like state
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Biology"
DOI: 10.1371/journal.pbio.3001682
Abstract: Around 60% of in vitro fertilized (IVF) human embryos irreversibly arrest before compaction between the 3- to 8-cell stage, posing a significant clinical problem. The mechanisms behind this arrest are unclear. Here, we show that… read more here.
Keywords: epigenetic dysfunctions; like state; metabolic epigenetic; human embryos ... See more keywords
Lactate induces metabolic and epigenetic reprogramming of pro‐inflammatory Th17 cells
Sign Up to like & getrecommendations! Published in 2022 at "EMBO reports"
DOI: 10.15252/embr.202254685
Abstract: Increased lactate levels in the tissue microenvironment are a well‐known feature of chronic inflammation. However, the role of lactate in regulating T cell function remains controversial. Here, we demonstrate that extracellular lactate predominantly induces deregulation… read more here.
Keywords: th17 cells; metabolic epigenetic; lactate; reprogramming pro ... See more keywords
Sirtuin-dependent metabolic and epigenetic regulation of macrophages during tuberculosis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1121495
Abstract: Macrophages are the preeminent phagocytic cells which control multiple infections. Tuberculosis a leading cause of death in mankind and the causative organism Mycobacterium tuberculosis (MTB) infects and persists in macrophages. Macrophages use reactive oxygen and… read more here.
Keywords: sirtuin dependent; metabolic epigenetic; regulation macrophages; dependent metabolic ... See more keywords