Precise Metabolomics Reveals a Diversity of Aging‐Associated Metabolic Features
Sign Up to like & getrecommendations! Published in 2022 at "Small Methods"
DOI: 10.1002/smtd.202200130
Abstract: Mass spectrometry‐based metabolomics has emerged as a powerful technique for biomedical research, although technical issues with its analytical precision and structural characterization remain. Herein, a robust non‐targeted strategy for accurate quantitation and precise profiling of… read more here.
Keywords: metabolism; metabolic features; metabolomics reveals; precise metabolomics ... See more keywords
Association of IL-1β, IL-1Ra and FABP1 gene polymorphisms with the metabolic features of polycystic ovary syndrome
Sign Up to like & getrecommendations! Published in 2017 at "Inflammation Research"
DOI: 10.1007/s00011-017-1045-3
Abstract: BackgroundPolycystic ovary syndrome (PCOS), a highly prevalent endocrinopathy is currently being designated as chronic low grade inflammatory state. IL-1β, IL-1Ra and FABP1 are critical mediators of inflammatory processes and are speculated to play a role… read more here.
Keywords: metabolic features; gene polymorphisms; association; fabp1 gene ... See more keywords
Impact of aerobic training with and without whole-body vibration training on metabolic features and quality of life in non-alcoholic fatty liver disease patients.
Sign Up to like & getrecommendations! Published in 2020 at "Annales d'endocrinologie"
DOI: 10.1016/j.ando.2020.05.003
Abstract: The present study examined the effectiveness of including exercises with whole-body vibration (WBV) to aerobic training in terms of metabolic features and quality of life. Patients with non-alcoholic fatty liver disease confirmed on imaging underwent… read more here.
Keywords: metabolic features; features quality; training; aerobic training ... See more keywords
Mechanistic Understanding of the Discrepancies between Common Peak Picking Algorithms in Liquid Chromatography-Mass Spectrometry-Based Metabolomics.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c04887
Abstract: Inconsistent peak picking outcomes are a critical concern in processing liquid chromatography-mass spectrometry (LC-MS)-based untargeted metabolomics data. This work systematically studied the mechanisms behind the discrepancies among five commonly used peak picking algorithms, including CentWave… read more here.
Keywords: picking algorithms; metabolic features; liquid chromatography; peak picking ... See more keywords
Enhancing metabolome coverage in data-dependent LC-MS/MS analysis through an integrated feature extraction strategy.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.9b02980
Abstract: In untargeted metabolomics, conventional data preprocessing software (e.g., XCMS, MZmine 2, MS-DIAL) are used extensively due to their high efficiency in metabolic feature extraction. However, these programs present limitations in recognizing low-abundance metabolic features, thus… read more here.
Keywords: extraction; metabolic features; metabolome coverage; integrated feature ... See more keywords
Adrenal incidentaloma: Do patients with apparently nonfunctioning mass or autonomous cortisol secretion have similar or different clinical and metabolic features?
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Endocrinology"
DOI: 10.1111/cen.14861
Abstract: Although there is growing evidence associating nonfunctioning adrenal incidentalomas (NFAI) with cardiovascular risk factors, there are limited data whether NFAI and autonomous cortisol secretion (ACS) groups have similar or different clinical and metabolic features. The… read more here.
Keywords: cortisol secretion; metabolic features; autonomous cortisol; similar different ... See more keywords
Metabolic features and glucocorticoid-induced comorbidities in patients with giant cell arteritis and polymyalgia rheumatica in a Dutch and Danish cohort
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DOI: 10.1136/rmdopen-2022-002640
Abstract: Objectives Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are age-associated inflammatory diseases that frequently overlap. Both diseases require long-term treatment with glucocorticoids (GCs), often associated with comorbidities. Previous population-based cohort studies reported that an… read more here.
Keywords: metabolic features; patients gca; gca pmr; giant cell ... See more keywords
Broad Learning Enhanced 1H-MRS for Early Diagnosis of Neuropsychiatric Systemic Lupus Erythematosus
Sign Up to like & getrecommendations! Published in 2020 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2020/8874521
Abstract: In this paper, we explore the potential of using the multivoxel proton magnetic resonance spectroscopy (1H-MRS) to diagnose neuropsychiatric systemic lupus erythematosus (NPSLE) with the assistance of a support vector machine broad learning system (BL-SVM).… read more here.
Keywords: broad learning; learning; metabolic features; systemic lupus ... See more keywords
Metabolic features of cancer cells
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DOI: 10.1186/s40880-018-0335-7
Abstract: Cancer cells uniquely reprogram their cellular activities to support their rapid proliferation and migration and to counteract metabolic and genotoxic stress during cancer progression. In this reprograming, cancer cells’ metabolism and other cellular activities are… read more here.
Keywords: metabolic features; features cancer; cellular activities; cancer cells ... See more keywords
Endocrinological, immunological and metabolic features of patients with Fabry disease under therapy
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Pediatric Endocrinology and Metabolism"
DOI: 10.1515/jpem-2023-0105
Abstract: Abstract Objectives Fabry disease is an X-linked lysosomal disorder caused by decreased or absent alpha galactosidase enzyme. The enzyme deficiency leads to progressive accumulation of globotriaosylceramide (Gb-3) and its deacetylated form lyso-Gb3 in various tissue… read more here.
Keywords: patients fabry; features patients; endocrinological immunological; metabolic features ... See more keywords
The impact of pulmonary tuberculosis on immunological and metabolic features of diabetic patients
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.973991
Abstract: Impaired immune responses have been observed in patients with type-2 diabetes mellitus (T2DM), which increases susceptibility to tuberculosis infection. However, the effect of the tuberculosis infection on the immunological and metabolic features of T2DM is… read more here.
Keywords: patients t2dm; metabolic features; tuberculosis; pulmonary tuberculosis ... See more keywords