Metabolic fitness in relation to genetic variation and leukocyte DNA methylation.
Sign Up to like & getrecommendations! Published in 2019 at "Physiological genomics"
DOI: 10.1152/physiolgenomics.00077.2018
Abstract: Metabolic syndrome (MetS) is a highly prevalent condition causing increased risk of several life-threatening diseases. MetS has a pronounced hereditary basis but is also influenced by environmental factors, partly through epigenetic mechanisms. In this study,… read more here.
Keywords: leukocyte dna; methylation; variation leukocyte; genetic variants ... See more keywords
Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues.
Sign Up to like & getrecommendations! Published in 2019 at "JCI insight"
DOI: 10.1172/jci.insight.129756
Abstract: Distinct subsets of Tregs reside in nonlymphoid tissues where they mediate unique functions. To interrogate the biology of tissue Tregs in human health and disease, we phenotypically and functionally compared healthy skin Tregs with those… read more here.
Keywords: skin; metabolic fitness; enhance metabolic; regulatory cells ... See more keywords
Loss of sphingosine kinase 2 promotes the expansion of hematopoietic stem cells by improving their metabolic fitness.
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2022016112
Abstract: Hematopoietic stem cells (HSCs) have reduced capacities to properly maintain and replenish the hematopoietic system during myelosuppressive injury or aging. Expanding and rejuvenating HSCs for therapeutic purposes has been a long-sought goal, with limited progress.… read more here.
Keywords: hscs; sphingosine kinase; hematopoietic stem; improving metabolic ... See more keywords