Differences in muscle energy metabolism and metabolic flexibility between sarcopenic and nonsarcopenic older adults.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cachexia, sarcopenia and muscle"
DOI: 10.1002/jcsm.12932
Abstract: BACKGROUND Metabolic flexibility is the ability of skeletal muscle to adapt fuel utilization to the demand for fuel sources [carbohydrates (CHO) and fats (FAT)]. The purpose of this study was to explore muscle energy metabolism… read more here.
Keywords: energy; min; cho; metabolic flexibility ... See more keywords
Metabolic flexibility is unimpaired during exercise in the cold following acute glucose ingestion in young healthy adults.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of thermal biology"
DOI: 10.1016/j.jtherbio.2021.102912
Abstract: PURPOSE Metabolic flexibility is compromised in individuals suffering from metabolic diseases, lipo- and glucotoxicity, and mitochondrial dysfunctions. Exercise studies performed in cold environments have demonstrated an increase in lipid utilization, which could lead to a… read more here.
Keywords: glucose ingestion; young healthy; metabolic flexibility; exercise ... See more keywords
Metabolic flexibility in melanoma: a potential therapeutic target.
Sign Up to like & getrecommendations! Published in 2019 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2019.07.016
Abstract: Cutaneous melanoma (CM) represents one of the most metastasizing and drug resistant solid tumors. CM is characterized by a remarkable metabolic plasticity and an important connection between oncogenic activation and energetic metabolism. In fact, melanoma… read more here.
Keywords: melanoma; melanoma potential; therapeutic target; flexibility melanoma ... See more keywords
Microglial metabolic flexibility supports immune surveillance of the brain parenchyma
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-15267-z
Abstract: Microglia are highly motile cells that continuously monitor the brain environment and respond to damage-associated cues. While glucose is the main energy substrate used by neurons in the brain, the nutrients metabolized by microglia to… read more here.
Keywords: immune surveillance; surveillance; flexibility supports; microglial metabolic ... See more keywords
Comparative genomic analysis reveals metabolic flexibility of Woesearchaeota
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-25565-9
Abstract: The archaeal phylum Woesearchaeota, within the DPANN superphylum, includes phylogenetically diverse microorganisms that inhabit various environments. Their biology is poorly understood due to the lack of cultured isolates. Here, we analyze datasets of Woesearchaeota 16S… read more here.
Keywords: analysis reveals; genomic analysis; comparative genomic; flexibility woesearchaeota ... See more keywords
Metabolic flexibility and extensive adaptability governing multiple drug resistance and enhanced virulence in Candida albicans
Sign Up to like & getrecommendations! Published in 2021 at "Critical Reviews in Microbiology"
DOI: 10.1080/1040841x.2021.1935447
Abstract: Abstract Commensal fungus-Candida albicans turn pathogenic during the compromised immunity of the host, causing infections ranging from superficial mucosal to dreadful systemic ones. C. albicans has evolved various adaptive measures which collectively contribute towards its… read more here.
Keywords: candida albicans; metabolic flexibility; enhanced virulence; virulence ... See more keywords
C9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis
Sign Up to like & getrecommendations! Published in 2019 at "Brain"
DOI: 10.1093/brain/awz302
Abstract: Energy metabolism is altered in amyotrophic lateral sclerosis and its animal models. Using metabolic profiling, Allen et al. reveal a loss of metabolic flexibility in induced astrocytes derived from patients with C9orf72 ALS, caused by… read more here.
Keywords: amyotrophic lateral; metabolic flexibility; lateral sclerosis; c9orf72 expansion ... See more keywords
Metabolic Flexibility: Interplay of Diet Composition and Intermittent Fasting on Healthspan (P08-053-19)
Sign Up to like & getrecommendations! Published in 2019 at "Current Developments in Nutrition"
DOI: 10.1093/cdn/nzz044.p08-053-19
Abstract: 4:10 periodic fasting schedule is proposed to improve biomarkers of healthspan through metabolic flexibility in mice on both standard and high fat diets. Our study adopted the 4:10 fasting schedule using the fasting-mimicking diet (FMD)… read more here.
Keywords: diet composition; flexibility; high fat; intermittent fasting ... See more keywords
Differential fuel utilization in liver transplant recipients and its relationship with nonâalcoholic fatty liver disease
Sign Up to like & getrecommendations! Published in 2022 at "Liver International"
DOI: 10.1111/liv.15178
Abstract: Metabolic flexibility is the ability to match biofuel availability to utilization. Reduced metabolic flexibility, or lower fatty acid (FA) oxidation in the fasted state, is associated with obesity. The present study evaluated metabolic flexibility after… read more here.
Keywords: fuel utilization; liver; metabolic flexibility; utilization liver ... See more keywords
Metabolic Flexibility During Exercise in Children with Overweight/Obesity Versus Children who are Lean.
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric exercise science"
DOI: 10.1123/pes.2021-0229
Abstract: PURPOSE This study examined metabolic flexibility with respect to fat metabolism during exercise in children who are lean (n=11; 10.9[0.9] y) and overweight/obese (OW/OB; n=9; 10.3[1.2] y). METHOD Participants were grouped based on body mass… read more here.
Keywords: children lean; metabolic flexibility; exercise children; exercise ... See more keywords
High-resolution respirometry (HRR)-derived assessment of human skeletal muscle respiratory control confirms loss of metabolic flexibility with aging and type 2 diabetes
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5729468
Abstract: Compromised metabolic flexibility is linked to skeletal muscle respiratory control limitations and associated with human senescence and pathological conditions, like type 2 diabetes mellitus (T2D). However, demonstrable proof of compromised metabolic flexibility is limited in… read more here.
Keywords: metabolic flexibility; flexibility; physiology; hrr ... See more keywords