Nicotinamide Phosphoribosyltransferase Acts as a Metabolic Gate for Mobilization of Myeloid-Derived Suppressor Cells.
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DOI: 10.1158/0008-5472.can-18-1544
Abstract: Cancer induces alteration of hematopoiesis to fuel disease progression. We report that in tumor-bearing mice the macrophage colony-stimulating factor elevates the myeloid cell levels of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in the NAD salvage… read more here.
Keywords: nicotinamide phosphoribosyltransferase; metabolic gate; mobilization; myeloid derived ... See more keywords