Coupling of Immunostimulants to Live Cells through Metabolic Glycoengineering and Bioorthogonal Click Chemistry.
Sign Up to like & getrecommendations! Published in 2017 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.7b00042
Abstract: The present study investigated the potential of metabolic glycoengineering followed by bioorthogonal click chemistry for introducing into cell-surface glycans different immunomodulating molecules. Mouse tumor models EG7 and MC38-OVA were treated with Ac4GalNAz and Ac4ManNAz followed… read more here.
Keywords: click chemistry; chemistry; metabolic glycoengineering; cell surface ... See more keywords
Equipping Natural Killer Cells with Cetuximab through Metabolic Glycoengineering and Bioorthogonal Reaction for Targeted Treatment of KRAS Mutant Colorectal Cancer.
Sign Up to like & getrecommendations! Published in 2021 at "ACS chemical biology"
DOI: 10.1021/acschembio.1c00022
Abstract: While Cetuximab can be used to treat KRAS wild-type colon cancer cells by targeting EGFR and inhibiting the activation of downstream signaling pathways, it exhibits little therapeutic effect on KRAS mutant colon cancer cells. Natural… read more here.
Keywords: natural killer; metabolic glycoengineering; kras mutant; cancer ... See more keywords
β-Galactosidase-dependent metabolic glycoengineering of tumor cells for imaging and immunotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc06575k
Abstract: A β-Gal-dependent metabolic glycoengineering strategy was developed for tumor cell-selective surface glycan imaging with high efficacy. Combined with an antibody-recruiting strategy, targeted immunotherapy was achieved successfully based on this strategy. read more here.
Keywords: tumor cells; glycoengineering tumor; dependent metabolic; metabolic glycoengineering ... See more keywords
Metabolic glycoengineering - exploring glycosylation with bioorthogonal chemistry.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Society reviews"
DOI: 10.1039/d2cs00764a
Abstract: Glycans are involved in numerous biological recognition events. Being secondary gene products, their labeling by genetic methods - comparable to GFP labeling of proteins - is not possible. To overcome this limitation, metabolic glycoengineering (MGE,… read more here.
Keywords: glycosylation bioorthogonal; exploring glycosylation; chemistry; metabolic glycoengineering ... See more keywords
Metabolic Glycoengineering: A Promising Strategy to Remodel Microenvironments for Regenerative Therapy
Sign Up to like & getrecommendations! Published in 2023 at "Stem Cells International"
DOI: 10.1155/2023/1655750
Abstract: Cell-based regenerative therapy utilizes the differentiation potential of stem cells to rejuvenate tissues. But the dynamic fate of stem cells is calling for precise control to optimize their therapeutic efficiency. Stem cell fate is regulated… read more here.
Keywords: cell; regenerative therapy; stem cells; metabolic glycoengineering ... See more keywords
The Applications of Metabolic Glycoengineering
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.840831
Abstract: Mammalian cell membranes are decorated by the glycocalyx, which offer versatile means of generating biochemical signals. By manipulating the set of glycans displayed on cell surface, it is vital for gaining insight into the cellular… read more here.
Keywords: applications metabolic; medicine; metabolic glycoengineering; cell surface ... See more keywords