Metabolic insight into bacterial community assembly across ecosystem boundaries.
Sign Up to like & getrecommendations! Published in 2020 at "Ecology"
DOI: 10.1002/ecy.2968
Abstract: The movement of organisms across habitat boundaries has important consequences for populations, communities, and ecosystems. However, because most species are not well adapted to all habitat types, dispersal into suboptimal habitats could induce physiological changes… read more here.
Keywords: insight bacterial; community assembly; community; metabolic insight ... See more keywords
Bacterial metabolic heterogeneity: origins and applications in engineering and infectious disease.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in biotechnology"
DOI: 10.1016/j.copbio.2020.04.007
Abstract: Bacteria within an isoclonal population display significant heterogeneity in metabolism, even under tightly controlled environmental conditions. Metabolic heterogeneity enables influential functions not possible or measurable at the ensemble scale. Several molecular and cellular mechanisms are… read more here.
Keywords: engineering; infectious disease; heterogeneity; metabolic heterogeneity ... See more keywords
Metabolic heterogeneity in clonal microbial populations.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in microbiology"
DOI: 10.1016/j.mib.2018.02.004
Abstract: In the past decades, numerous instances of phenotypic diversity were observed in clonal microbial populations, particularly, on the gene expression level. Much less is, however, known about phenotypic differences that occur on the level of… read more here.
Keywords: metabolism; clonal microbial; heterogeneity clonal; microbial populations ... See more keywords
Label-free sensing of cells with fluorescence lifetime imaging: The quest for metabolic heterogeneity
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2118241119
Abstract: Significance Tumors are complex systems characterized by spatial heterogeneity at the genetic, molecular, and cellular levels. Tumor heterogeneity is the critical phenomenon determining the difference in therapeutic outcomes for patients with similar histological diagnosis. Metabolic… read more here.
Keywords: heterogeneity; fluorescence lifetime; metabolic heterogeneity; lifetime imaging ... See more keywords
Value of Intratumoral Metabolic Heterogeneity and Quantitative 18F-FDG PET/CT Parameters to Predict Prognosis in Patients With HPV-Positive Primary Oropharyngeal Squamous Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Nuclear Medicine"
DOI: 10.1097/rlu.0000000000001578
Abstract: Objective The aim of this study was to evaluate the impact of intratumoral metabolic heterogeneity and quantitative FDG PET/CT imaging parameters for predicting patient outcomes in primary oropharyngeal squamous cell cancer (OPSCC). Patients and Methods… read more here.
Keywords: primary oropharyngeal; heterogeneity; fdg pet; heterogeneity quantitative ... See more keywords
Label-free sensing of cells with fluorescence lifetime imaging: The quest for metabolic heterogeneity
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1101/2022.01.12.476038
Abstract: Molecular, morphological and physiological heterogeneity is the inherent property of cells, which governs differences in their response to external influence. The tumor cells metabolic heterogeneity is of a special interest due to its clinical relevance… read more here.
Keywords: heterogeneity; lifetime imaging; fluorescence lifetime; metabolic heterogeneity ... See more keywords
The Spatial Metabolic Heterogeneity of Solid Type of Enrlich Carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Doklady Biochemistry and Biophysics"
DOI: 10.1134/s1607672919030177
Abstract: In this work, we investigated the NAD(P)-dependent dehydrogenase activity in different fields of the solid form of Ehrlich carcinoma. It was shown that there is a metabolic distinction between different fields of the solid tumor.… read more here.
Keywords: carcinoma; solid type; heterogeneity solid; metabolic heterogeneity ... See more keywords
Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity.
Sign Up to like & getrecommendations! Published in 2020 at "Annual review of food science and technology"
DOI: 10.1146/annurev-food-032519-051736
Abstract: People differ in their requirements for and responses to nutrients and bioactive molecules in the diet. Many inputs contribute to metabolic heterogeneity (including variations in genetics, epigenetics, microbiome, lifestyle, diet intake, and environmental exposure). Precision… read more here.
Keywords: precision nutrition; nutrition; metabolic heterogeneity; personalized nutrition ... See more keywords
High metabolic heterogeneity on baseline 18FDG-PET/CT scan as a poor prognostic factor for newly diagnosed diffuse large B-cell lymphoma.
Sign Up to like & getrecommendations! Published in 2020 at "Blood advances"
DOI: 10.1182/bloodadvances.2020001816
Abstract: Metabolic heterogeneity (MH) can be measured using 18F-fluorodeoxyglucose (18FDG) positron emission tomography/computed tomography (PET/CT), and it indicates an inhomogeneous tumor microenvironment. High MH has been shown to predict a worse prognosis for primary mediastinal B-cell… read more here.
Keywords: newly diagnosed; large cell; diffuse large; metabolic heterogeneity ... See more keywords
Spatially resolved characterization of tissue metabolic compartments in fasted and high-fat diet livers
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0261803
Abstract: Cells adapt their metabolism to physiological stimuli, and metabolic heterogeneity exists between cell types, within tissues, and subcellular compartments. The liver plays an essential role in maintaining whole-body metabolic homeostasis and is structurally defined by… read more here.
Keywords: metabolic heterogeneity; high fat; spatially resolved; tissue ... See more keywords
Predictive value of intratumoral-metabolic heterogeneity derived from 18F-FDG PET/CT in distinguishing microsatellite instability status of colorectal carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1065744
Abstract: Purpose/background Microsatellite instability (MSI) status is a significant biomarker for the response to immune checkpoint inhibitors, response to 5-fluorouracil-based adjuvant chemotherapy, and prognosis in colorectal carcinoma (CRC). This study investigated the predictive value of intratumoral-metabolic… read more here.
Keywords: heterogeneity; intratumoral metabolic; metabolic heterogeneity; fdg pet ... See more keywords