Tumor-Specific Peroxynitrite Overproduction Disrupts Metabolic Homeostasis for Sensitizing Melanoma Immunotherapy.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202301455
Abstract: Tumor cells elicit metabolic reprogramming to establish an immunosuppressive tumor microenvironment (TME) for escaping from immunosurveillance. Therefore, interrupting the metabolic adaption of tumor cells might be a promising strategy for TME immunomodulation, favoring immunotherapy. Herein,… read more here.
Keywords: tumor specific; overproduction; melanoma; tumor ... See more keywords
Neuregulin4 Acts on Hypothalamic ErBb4 to Excite Oxytocin Neurons and Preserve Metabolic Homeostasis
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202204824
Abstract: Neuregulin 4 (Nrg4) is an adipose tissue‐enriched secreted factor that modulates glucose and lipid metabolism. Nrg4 is closely associated with obesity and preserves diet‐induced metabolic disorders. However, the specific mechanisms via which Nrg4 regulates metabolic… read more here.
Keywords: neuregulin4 acts; hypothalamic erbb4; erbb4; obesity ... See more keywords
Sex-Dependent Role of Estrogen Sulfotransferase and Steroid Sulfatase in Metabolic Homeostasis.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-70178-3_21
Abstract: Sulfonation and desulfation are two opposing processes that represent an important layer of regulation of estrogenic activity via ligand supplies. Enzymatic activities of families of enzymes, known as sulfotransferases and sulfatases, lead to structural and… read more here.
Keywords: metabolic homeostasis; estrogen; estrogen sulfotransferase; steroid sulfatase ... See more keywords
The circadian clock and metabolic homeostasis: entangled networks
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-021-03800-2
Abstract: The circadian clock exerts an important role in systemic homeostasis as it acts a keeper of time for the organism. The synchrony between the daily challenges imposed by the environment needs to be aligned with… read more here.
Keywords: metabolic homeostasis; circadian clock; clock metabolic; clock ... See more keywords
LncRNA LncHrt preserves cardiac metabolic homeostasis and heart function by modulating the LKB1-AMPK signaling pathway
Sign Up to like & getrecommendations! Published in 2021 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-021-00887-3
Abstract: Metabolic modulation is a promising therapeutic approach to prevent adverse remodeling of the ischemic heart. Because little is known about the involvement of long non-coding RNAs (lncRNAs) in regulating cardiac metabolism, we used unbiased transcriptome… read more here.
Keywords: heart; metabolic homeostasis; lkb1 ampk; cardiac metabolic ... See more keywords
Adipocyte ACLY Facilitates Dietary Carbohydrate Handling to Maintain Metabolic Homeostasis in Females
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.04.112
Abstract: SUMMARY Sugars and refined carbohydrates are major components of the modern diet. ATP-citrate lyase (ACLY) is upregulated in adipocytes in response to carbohydrate consumption and generates acetyl-coenzyme A (CoA) for both lipid synthesis and acetylation… read more here.
Keywords: metabolic homeostasis; acly facilitates; adipocyte acly; carbohydrate ... See more keywords
Neuronal XRN1 is required for maintenance of whole-body metabolic homeostasis
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.103151
Abstract: Summary Control of mRNA stability and degradation is essential for appropriate gene expression, and its dysregulation causes various disorders, including cancer, neurodegenerative diseases, diabetes, and obesity. The 5′–3′ exoribonuclease XRN1 executes the last step of… read more here.
Keywords: metabolic homeostasis; maintenance; mice; xrn1 cko ... See more keywords
Diiodothyronines regulate metabolic homeostasis in primary human hepatocytes by modulating mTORC1 and mTORC2 activity
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2019.110604
Abstract: Until three decades, ago 3,5-diiodothyronine (3,5-T2) and 3,3'-diiodothyronine (3,3'-T2) were considered products of thyroid hormone catabolism without biological activity. Some metabolic effects have been described in rodents, but the physiological relevance in humans and the… read more here.
Keywords: diiodothyronines regulate; metabolic homeostasis; human hepatocytes; primary human ... See more keywords
AMPK: restoring metabolic homeostasis over space and time.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular cell"
DOI: 10.1016/j.molcel.2021.08.015
Abstract: The evolution of AMPK and its homologs enabled exquisite responsivity and control of cellular energetic homeostasis. Recent work has been critical in establishing the mechanisms that determine AMPK activity, novel targets of AMPK action, and… read more here.
Keywords: homeostasis; ampk restoring; metabolic homeostasis; control ... See more keywords
Genomic Profiling and Metabolic Homeostasis in Primary Liver Cancers.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in molecular medicine"
DOI: 10.1016/j.molmed.2018.02.006
Abstract: Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA), the two most common primary liver cancers, represent the second most common cancer-related cause of death worldwide, with most cases being diagnosed at an advanced stage. Recent genome-wide… read more here.
Keywords: metabolic homeostasis; liver; primary liver; profiling metabolic ... See more keywords
TCA cycle off, ATF4 on for metabolic homeostasis.
Sign Up to like & getrecommendations! Published in 2022 at "Trends in biochemical sciences"
DOI: 10.1016/j.tibs.2022.03.006
Abstract: Tricarboxylic acid (TCA) cycle is a major hub for catabolic and anabolic reactions, yet cellular metabolic adaptations following its inhibition are largely unknown. Using multi-tiered omics approaches, Ryan et al. have shown convergent activation of… read more here.
Keywords: atf4 metabolic; cycle; tca cycle; cycle atf4 ... See more keywords