TRIM65/NF2/YAP1 Signaling Coordinately Orchestrates Metabolic and Immune Advantages in Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202402578
Abstract: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer deaths worldwide. Significantly activated uridine nucleotide and fatty acid metabolism in HCC cells promote malignant proliferation and immune evasion. Herein, it is demonstrated that… read more here.
Keywords: immune advantages; hcc; hepatocellular carcinoma; metabolic immune ... See more keywords
Appetite Changes Reveal Depression Subgroups with Distinct Endocrine, Metabolic, and Immune States
Sign Up to like & getrecommendations! Published in 2018 at "Molecular psychiatry"
DOI: 10.1038/s41380-018-0093-6
Abstract: There exists little human neuroscience research to explain why some individuals lose their appetite when they become depressed, while others eat more. Answering this question may reveal much about the various pathophysiologies underlying depression. The… read more here.
Keywords: depression subgroups; depression; endocrine metabolic; food cues ... See more keywords
Metabolic and immune-sensitive contacts between lipid droplets and endoplasmic reticulum reconstituted in vitro
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2200513119
Abstract: Significance The intricate membranous network inside cells, with the endoplasmic reticulum (ER) at its center, allows coordinated cellular function by transmitting information across membrane contact sites (MCSs) that form between diverse kinds of cellular organelles… read more here.
Keywords: metabolic immune; endoplasmic reticulum; lipid droplets; sensitive contacts ... See more keywords
Metabolic and immune crosstalk between cancer-associated fibroblasts and pancreatic cancer cells
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-025-07164-0
Abstract: Pancreatic cancer, specifically pancreatic ductal adenocarcinoma (PDAC), is notorious for its aggressive nature and dismal prognosis, ranking as a leading cause of cancer-related mortality worldwide. Despite advancements in surgical techniques, chemotherapies, and novel therapeutic approaches,… read more here.
Keywords: cancer; cancer cells; metabolic immune; associated fibroblasts ... See more keywords
Metabolic-Inflammatory Syndrome: Decoding the Metabolic-Immune Axis for Precision Intervention.
Sign Up to like & getrecommendations! Published in 2025 at "Aging and disease"
DOI: 10.14336/ad.2025.1125
Abstract: Metabolic-inflammatory syndrome represents a major global health challenge, closely linked to diabetes, cardiovascular disease, obesity, and non-alcoholic fatty liver disease. The core of these disorders involves remodeling of metabolic pathways under nutritional stress and the… read more here.
Keywords: metabolic immune; metabolic inflammatory; inflammatory syndrome; immune axis ... See more keywords
The value of a metabolic and immune-related gene signature and adjuvant therapeutic response in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2024.1475378
Abstract: Background Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by a dismal prognosis. Treatment outcomes exhibit substantial variability across patients, underscoring the urgent need for robust predictive models to effectively estimate survival probabilities… read more here.
Keywords: value metabolic; metabolic immune; immune related; gene signature ... See more keywords
Editorial: Role of hypoxia-inducible factors in metabolic immune cell adaptation during sepsis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1194504
Abstract: COPYRIGHT © 2023 del Fresno, Schulte and LópezCollazo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted,… read more here.
Keywords: metabolic immune; inducible factors; role hypoxia; hypoxia inducible ... See more keywords
Lactylation-related gene AKR1A1 contributes to osteoporosis via metabolic–immune regulation: evidence from multi-omics integration, single-cell transcriptomics, and in vitro validation
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2025.1680305
Abstract: Objective This study aimed to systematically identify key differentially expressed genes (DEGs) associated with lysine lactylation in osteoporosis and to explore their potential roles in disease pathogenesis from a dual perspective of metabolic and immune… read more here.
Keywords: single cell; lactylation related; lactylation; metabolic immune ... See more keywords
Single-Nucleus Transcriptomics Reveals Glial Metabolic–Immune Rewiring and Intercellular Signaling Disruption in Chronic Migraine
Sign Up to like & getrecommendations! Published in 2025 at "Biomolecules"
DOI: 10.3390/biom15070942
Abstract: Chronic migraine (CM) is a debilitating neurological disorder, yet the glial-specific mechanisms underlying its pathophysiology in the trigeminal nucleus caudalis (TNC)—a critical hub for craniofacial pain processing—remain poorly understood. Here, we employed single-nucleus RNA sequencing… read more here.
Keywords: chronic migraine; metabolic immune; single nucleus; nucleus transcriptomics ... See more keywords
Association of Adiponectin Receptors with Metabolic and Immune Homeostasis Parameters in Colorectal Cancer: In Silico Analysis and Observational Findings
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Environmental Research and Public Health"
DOI: 10.3390/ijerph192214995
Abstract: Adiponectin (ADIPOQ) as both a regulator of metabolic homeostasis and a protein involved in immune response might be of particular interest to contemporary laboratory medicine, especially in terms of minimally invasive diagnostics. The diverse roles… read more here.
Keywords: metabolic immune; adipor1; immune homeostasis; mrna levels ... See more keywords
Irradiation-Induced Dysbiosis: The Compounding Effect of High-Fat Diet on Metabolic and Immune Functions in Mice
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24065631
Abstract: The negative impact of irradiation or diet on the metabolic and immune profiles of cancer survivors have been previously demonstrated. The gut microbiota plays a critical role in regulating these functions and is highly sensitive… read more here.
Keywords: metabolic immune; effect; immune functions; high fat ... See more keywords