Modulation of nutrient precursors for controlling metabolic inhibitors by genome‐scale flux balance analysis
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DOI: 10.1002/btpr.3313
Abstract: Therapeutic protein productivity and glycosylation pattern highly rely on cell metabolism. Cell culture medium composition and feeding strategy are critical to regulate cell metabolism. In this study, the relationship between toxic metabolic inhibitors and their… read more here.
Keywords: cell; cell metabolism; flux balance; nutrient precursors ... See more keywords
Treatment of Pancreatic Cancer Patient–Derived Xenograft Panel with Metabolic Inhibitors Reveals Efficacy of Phenformin
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DOI: 10.1158/1078-0432.ccr-17-1115
Abstract: Purpose: To identify effective metabolic inhibitors to suppress the aggressive growth of pancreatic ductal adenocarcinoma (PDAC), we explored the in vivo antitumor efficacy of metabolic inhibitors, as single agents, in a panel of patient-derived PDAC… read more here.
Keywords: inhibitor; metabolic inhibitors; treatment; phenformin ... See more keywords