Metabolism drives monocytes during inflammation: What we do and do not know
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3ce1118-448r
Abstract: The quest for discovering novel therapeutics to treat acute inflammatory conditions such as sepsis has been a significant challenge for scientists and physicians. Despite promising discoveries using animal models, innumerable clinical trials have failed to… read more here.
Keywords: activation; sepsis; biology; metabolic intermediates ... See more keywords
Efficient Production of Polymalic Acid by a Novel Isolated Aureobasidium pullulans Using Metabolic Intermediates and Inhibitors
Sign Up to like & getrecommendations! Published in 2018 at "Applied Biochemistry and Biotechnology"
DOI: 10.1007/s12010-018-2825-0
Abstract: Polymalic acid (PMA) is a linear anionic polyester composed of l-malic acid monomers, which have potential applications as drug carriers, surgical suture, and biodegradable plastics. In this study, a novel strain of Aureobasidium pullulans var.… read more here.
Keywords: pma; production; polymalic acid; metabolic intermediates ... See more keywords
Metabolic intermediates – Cellular messengers talking to chromatin modifiers
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2018.01.007
Abstract: Background To maintain homeostasis, cells need to coordinate the expression of their genes. Epigenetic mechanisms controlling transcription activation and repression include DNA methylation and post-translational modifications of histones, which can affect the architecture of chromatin… read more here.
Keywords: intermediates cellular; chromatin; metabolic intermediates; modifying enzymes ... See more keywords
The aldehyde hypothesis: metabolic intermediates as antimicrobial effectors
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DOI: 10.1098/rsob.220010
Abstract: There are many reactive intermediates found in metabolic pathways. Could these potentially toxic molecules be exploited for an organism's benefit? We propose that during certain microbial infections, the production of inherently reactive aldehydes by an… read more here.
Keywords: antimicrobial effectors; metabolic intermediates; intermediates antimicrobial; hypothesis metabolic ... See more keywords
Metabolic Intermediates in Tumorigenesis and Progression
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DOI: 10.7150/ijbs.33496
Abstract: Traditional antitumor drugs inhibit the proliferation and metastasis of tumour cells by restraining the replication and expression of DNA. These drugs are usually highly cytotoxic. They kill tumour cells while also cause damage to normal… read more here.
Keywords: normal cells; tumour cells; metabolic intermediates; tumorigenesis progression ... See more keywords