Metabolic transcriptional memory
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2020.01.019
Abstract: Background Organisms can be primed by metabolic exposures to continue expressing response genes even once the metabolite is no longer available, and can affect the speed and magnitude of responsive gene expression during subsequent exposures.… read more here.
Keywords: metabolic memory; transcriptional memory; memory; metabolic transcriptional ... See more keywords
Inheritable testicular metabolic memory of high-fat diet causes transgenerational sperm defects in mice
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-88981-3
Abstract: The consumption of energy-dense diets has contributed to an increase in the prevalence of obesity and its comorbidities worldwide. The adoption of unhealthy feeding habits often occurs at early age, prompting the early onset of… read more here.
Keywords: sperm; high fat; causes transgenerational; metabolic memory ... See more keywords
Astragalus polysaccharide attenuates metabolic memory-triggered ER stress and apoptosis via regulation of miR-204/SIRT1 axis in retinal pigment epithelial cells
Sign Up to like & getrecommendations! Published in 2020 at "Bioscience Reports"
DOI: 10.1042/bsr20192121
Abstract: Abstract Background: ‘Metabolic memory’ of early hyperglycaemic environment has been frequently suggested in the progression of diabetic retinopathy (DR). Retinal pigment epithelial (RPE) cells are crucial targets for DR initiation following hyperglycaemia. Astragalus polysaccharides (APS)… read more here.
Keywords: 204 sirt1; mir 204; metabolic memory; apoptosis ... See more keywords
Metabolic memory in Mycobacterium.
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.357.6346.44-c
Abstract: Tuberculosis Tuberculosis is a slow disease. Replication of the pathogen, Mycobacterium tuberculosis , can be arrested for decades within hypoxic tubercles. Eoh et al. show that hypoxia shifts the metabolism of M. tuberculosis into the… read more here.
Keywords: metabolic memory; tuberculosis; mycobacterium; memory mycobacterium ... See more keywords
Astragalus polysaccharides suppresses high glucose-induced metabolic memory in retinal pigment epithelial cells through inhibiting mitochondrial dysfunction-induced apoptosis by regulating miR-195
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Medicine"
DOI: 10.1186/s10020-019-0088-z
Abstract: BackgroundMetabolic memory contributes to the development of diabetic retinopathy (DR), which is the complication of diabetes. But it’s still unknown how to prevent the metabolic memory to treat the DR. In our study, we want… read more here.
Keywords: mir 195; apoptosis; metabolic memory; retinal pigment ... See more keywords
Understanding Metabolic Memory: A Tale of Two Studies
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes"
DOI: 10.2337/db19-0514
Abstract: The results of the Diabetes Control and Complications Trial (DCCT) have given rise to much encouragement in the battle to stave off the complications of type 1 diabetes, showing dramatic declines in the development of… read more here.
Keywords: metabolic memory; exposure; memory tale; epidemiology ... See more keywords
When Does Metabolic Memory Start? Insights From the Association of Medical Diabetologists Annals Initiative on Stringent HbA1c Targets
Sign Up to like & getrecommendations! Published in 2024 at "Diabetes"
DOI: 10.2337/db24-0166
Abstract: Early, intensive glycemic control in patients with type 2 diabetes (T2D) is associated with long-term benefits in cardiovascular disease (CVD) development. Evidence on benefits of achieving HbA1c targets close to normal values is scant. Individuals… read more here.
Keywords: mean hba1c; hba1c targets; cvd; type diabetes ... See more keywords
Epigenetic Mechanisms in Diabetic Vascular Complications and Metabolic Memory: The 2020 Edwin Bierman Award Lecture
Sign Up to like & getrecommendations! Published in 2021 at "Diabetes"
DOI: 10.2337/dbi20-0030
Abstract: Macrovascular complications such as atherosclerosis, myocardial infarction and stroke, and microvascular complications such as nephropathy, retinopathy, and neuropathy are the major causes of increased morbidity and mortality in both type 1 and type 2 diabetes.… read more here.
Keywords: diabetic vascular; metabolic memory; complications metabolic; epigenetic mechanisms ... See more keywords
Understanding Metabolic Memory: The Prolonged Influence of Glycemia During the Diabetes Control and Complications Trial (DCCT) on Future Risks of Complications During the Study of the Epidemiology of Diabetes Interventions and Complications (EDIC)
Sign Up to like & getrecommendations! Published in 2021 at "Diabetes Care"
DOI: 10.2337/dc20-3097
Abstract: The Diabetes Control and Complications Trial (DCCT, 1983–1993) showed that intensive therapy (mean HbA1c 7.2%) compared with conventional therapy (mean HbA1c 9.0%) markedly reduced the risks of retinopathy, nephropathy, and neuropathy, and these reductions in… read more here.
Keywords: metabolic memory; hba1c; epidemiology; diabetes control ... See more keywords
Parameters of Micro- and Macrocirculation in Young Uncomplicated Type 1 Diabetic Patients—The Role of Metabolic Memory
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms262010156
Abstract: In the current study, we focus on analyzing the relationship between changes in micro- and macrocirculation and different stages of metabolic memory. We hypothesized that early poor glycemic control induces lasting endothelial changes detectable in… read more here.
Keywords: duration; uncomplicated type; memory; micro macrocirculation ... See more keywords
Metabolic memory and diabetic retinopathy: Legacy of glycemia and possible steps into future
Sign Up to like & getrecommendations! Published in 2024 at "Indian Journal of Ophthalmology"
DOI: 10.4103/ijo.ijo_2563_23
Abstract: The response of retinal pathology to interventions in diabetic retinopathy (DR) is often independent of the glycated hemoglobin (HbA1c) values at the point of care. This is despite glucose control being one of the strongest… read more here.
Keywords: memory diabetic; memory; legacy glycemia; metabolic memory ... See more keywords