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Published in 2020 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2020.01.019
Abstract: Background Organisms can be primed by metabolic exposures to continue expressing response genes even once the metabolite is no longer available, and can affect the speed and magnitude of responsive gene expression during subsequent exposures.…
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Keywords:
metabolic memory;
transcriptional memory;
memory;
metabolic transcriptional ... See more keywords
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Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-88981-3
Abstract: The consumption of energy-dense diets has contributed to an increase in the prevalence of obesity and its comorbidities worldwide. The adoption of unhealthy feeding habits often occurs at early age, prompting the early onset of…
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Keywords:
sperm;
high fat;
causes transgenerational;
metabolic memory ... See more keywords
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Published in 2020 at "Bioscience Reports"
DOI: 10.1042/bsr20192121
Abstract: Abstract Background: ‘Metabolic memory’ of early hyperglycaemic environment has been frequently suggested in the progression of diabetic retinopathy (DR). Retinal pigment epithelial (RPE) cells are crucial targets for DR initiation following hyperglycaemia. Astragalus polysaccharides (APS)…
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Keywords:
204 sirt1;
mir 204;
metabolic memory;
apoptosis ... See more keywords
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Published in 2017 at "Science"
DOI: 10.1126/science.357.6346.44-c
Abstract: Tuberculosis Tuberculosis is a slow disease. Replication of the pathogen, Mycobacterium tuberculosis , can be arrested for decades within hypoxic tubercles. Eoh et al. show that hypoxia shifts the metabolism of M. tuberculosis into the…
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Keywords:
metabolic memory;
tuberculosis;
mycobacterium;
memory mycobacterium ... See more keywords
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Published in 2019 at "Molecular Medicine"
DOI: 10.1186/s10020-019-0088-z
Abstract: BackgroundMetabolic memory contributes to the development of diabetic retinopathy (DR), which is the complication of diabetes. But it’s still unknown how to prevent the metabolic memory to treat the DR. In our study, we want…
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Keywords:
mir 195;
apoptosis;
metabolic memory;
retinal pigment ... See more keywords
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Published in 2020 at "Diabetes"
DOI: 10.2337/db19-0514
Abstract: The results of the Diabetes Control and Complications Trial (DCCT) have given rise to much encouragement in the battle to stave off the complications of type 1 diabetes, showing dramatic declines in the development of…
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Keywords:
metabolic memory;
exposure;
memory tale;
epidemiology ... See more keywords
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Published in 2021 at "Diabetes"
DOI: 10.2337/dbi20-0030
Abstract: Macrovascular complications such as atherosclerosis, myocardial infarction and stroke, and microvascular complications such as nephropathy, retinopathy, and neuropathy are the major causes of increased morbidity and mortality in both type 1 and type 2 diabetes.…
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Keywords:
diabetic vascular;
metabolic memory;
complications metabolic;
epigenetic mechanisms ... See more keywords
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Published in 2021 at "Diabetes Care"
DOI: 10.2337/dc20-3097
Abstract: The Diabetes Control and Complications Trial (DCCT, 1983–1993) showed that intensive therapy (mean HbA1c 7.2%) compared with conventional therapy (mean HbA1c 9.0%) markedly reduced the risks of retinopathy, nephropathy, and neuropathy, and these reductions in…
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Keywords:
metabolic memory;
hba1c;
epidemiology;
diabetes control ... See more keywords