O099 A relevant metabolic model for monitoring human metabolism in vivo using dynamic nuclear polarization with 13C magnetic resonance spectroscopy
Sign Up to like & getrecommendations! Published in 2023 at "British Journal of Surgery"
DOI: 10.1093/bjs/znad101.099
Abstract: DNP increases the signal of carbon-13 molecules on MR scans (>10,000-fold), enabling real-time, dynamic quantitation of tissue metabolism in vivo with significant clinical potential. 13C quantification of metabolism is affected by confounding factors (T1 signal… read more here.
Keywords: spectroscopy; metabolism vivo; model; metabolic model ... See more keywords
Metabolic Model of the Nitrogen-Fixing Obligate Aerobe Azotobacter vinelandii Predicts Its Adaptation to Oxygen Concentration and Metal Availability
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DOI: 10.1128/mbio.02593-21
Abstract: The world’s dependence on industrially produced nitrogenous fertilizers has created a dichotomy of issues. First, parts of the globe lack access to fertilizers, leading to poor crop yields that significantly limit nutrition while contributing to… read more here.
Keywords: mechanism; oxygen; metabolic model; nitrogen fixing ... See more keywords
Insights into metabolic osmoadaptation of the ectoines-producer bacterium Chromohalobacter salexigens through a high-quality genome scale metabolic model
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DOI: 10.1186/s12934-017-0852-0
Abstract: BackgroundThe halophilic bacterium Chromohalobacter salexigens is a natural producer of ectoines, compatible solutes with current and potential biotechnological applications. As production of ectoines is an osmoregulated process that draws away TCA intermediates, bacterial metabolism needs… read more here.
Keywords: production; high quality; quality genome; model ... See more keywords
Towards creating an extended metabolic model (EMM) for E. coli using enzyme promiscuity prediction and metabolomics data
Sign Up to like & getrecommendations! Published in 2019 at "Microbial Cell Factories"
DOI: 10.1186/s12934-019-1156-3
Abstract: BackgroundMetabolic models are indispensable in guiding cellular engineering and in advancing our understanding of systems biology. As not all enzymatic activities are fully known and/or annotated, metabolic models remain incomplete, resulting in suboptimal computational analysis… read more here.
Keywords: enzyme promiscuity; model emm; extended metabolic; model ... See more keywords
Comprehensive reconstruction and evaluation of Pichia pastoris genome-scale metabolic model that accounts for 1243 ORFs
Sign Up to like & getrecommendations! Published in 2017 at "Bioresources and Bioprocessing"
DOI: 10.1186/s40643-017-0152-x
Abstract: BackgroundPichia pastoris is one of the most important cell factories for production of industrial enzymes and heterogenous proteins. The genome-scale metabolic model of high quality is crucial for comprehensive understanding of the P. pastoris metabolism.MethodsIn… read more here.
Keywords: genome scale; model; scale metabolic; metabolic model ... See more keywords
A new metabolic model of Drosophila melanogaster and the integrative analysis of Parkinson’s disease
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DOI: 10.26508/lsa.202201695
Abstract: The reconstruction of a comprehensive and literature-curated Drosophila metabolic model, iDrosophila1, provided a powerful platform for studying metabolism with systems medicine perspective. read more here.
Keywords: model drosophila; new metabolic; model; melanogaster integrative ... See more keywords
Construction and application of the genome-scale metabolic model of Streptomyces radiopugnans
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2023.1108412
Abstract: Geosmin is one of the most common earthy-musty odor compounds, which is mainly produced by Streptomyces. Streptomyces radiopugnans was screened in radiation-polluted soil, which has the potential to overproduce geosmin. However, due to the complex… read more here.
Keywords: scale metabolic; model izdz767; streptomyces radiopugnans; model ... See more keywords
Metabolic model of necrotizing enterocolitis in the premature newborn gut resulting from enteric dysbiosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pediatrics"
DOI: 10.3389/fped.2022.893059
Abstract: Necrotizing enterocolitis (NEC) is a leading cause of premature newborn morbidity and mortality. The clinical features of NEC consistently include prematurity, gut dysbiosis and enteral inflammation, yet the pathogenesis remains obscure. Herein we combine metagenomics… read more here.
Keywords: premature newborn; dysbiosis; newborn gut; necrotizing enterocolitis ... See more keywords
Construction and Analysis of an Enzyme-Constrained Metabolic Model of Corynebacterium glutamicum
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DOI: 10.3390/biom12101499
Abstract: The genome-scale metabolic model (GEM) is a powerful tool for interpreting and predicting cellular phenotypes under various environmental and genetic perturbations. However, GEM only considers stoichiometric constraints, and the simulated growth and product yield values… read more here.
Keywords: corynebacterium glutamicum; enzyme constrained; glutamicum; model ... See more keywords
Development of a Genome-Scale Metabolic Model and Phenome Analysis of the Probiotic Escherichia coli Strain Nissle 1917
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DOI: 10.3390/ijms22042122
Abstract: Escherichia coli Nissle 1917 (EcN) is an intestinal probiotic that is effective for the treatment of intestinal disorders, such as inflammatory bowel disease and ulcerative colitis. EcN is a representative Gram-negative probiotic in biomedical research… read more here.
Keywords: escherichia coli; phenome analysis; model; metabolic model ... See more keywords
Reconstructed Genome-Scale Metabolic Model Characterizes Adaptive Metabolic Flux Changes in Peripheral Blood Mononuclear Cells in Severe COVID-19 Patients
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232012400
Abstract: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) poses a mortal threat to human health. The elucidation of the relationship between peripheral immune cells and the development of inflammation is essential… read more here.
Keywords: scale metabolic; changes peripheral; peripheral blood; adaptive metabolic ... See more keywords