14C-Tracing of Lipid Metabolism.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1362-7_5
Abstract: Lipids are produced through a dynamic metabolic network involving branch points, cycles, reversible reactions, parallel reactions in different subcellular compartments, and distinct pools of the same lipid class involved in different parts of the network.… read more here.
Keywords: metabolism; metabolic network; lipid metabolic; lipid metabolism ... See more keywords
Dynamic metabolic network modeling of mammalian Chinese hamster ovary (CHO) cell cultures with continuous phase kinetics transitions
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical Engineering Journal"
DOI: 10.1016/j.bej.2018.11.015
Abstract: Abstract Cellular biological environments are difficult to analyse on the first principle basis. In this modeling work, a novel approach is presented which transits from a broad mechanistic description of the individual metabolic pathways to… read more here.
Keywords: metabolic network; chinese hamster; cell; ovary cho ... See more keywords
Establishing the metabolic network of isoquinoline alkaloids from the Macleaya genus.
Sign Up to like & getrecommendations! Published in 2021 at "Phytochemistry"
DOI: 10.1016/j.phytochem.2021.112696
Abstract: Metabolic networks can provide insight into the biosynthesis pathways of natural products present in plant-derived medicines. Here, we primarily established a highly efficient and targeted method for the systematic screening of isoquinoline alkaloids from the… read more here.
Keywords: macleaya genus; isoquinoline alkaloids; metabolic network; alkaloids macleaya ... See more keywords
DLEMMA-MS-Imaging for Identification of Spatially Localized Metabolites and Metabolic Network Map Reconstruction.
Sign Up to like & getrecommendations! Published in 2018 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.8b01644
Abstract: Regardless of major advances in mass spectrometry imaging (MSI), there are three intrinsic limitations associated with MSI, including intricate molecular identification, low molecular coverage, and incapability to obtain "true" spatial distribution due to isobaric and… read more here.
Keywords: imaging identification; identification spatially; dlemma imaging; spatially localized ... See more keywords
Reprogramming the Metabolic Network in Kluyveromyces lactis with a Transcriptional Switch for De Novo Lacto-N-biose Synthesis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.3c01779
Abstract: Lacto-N-biose (LNB) is a member of the human milk oligosaccharide (HMO) family and is synthesized via an enzymatic reaction in vitro with N-acetylglucosamine (GlcNAc) and cofactors. In this study, LNB was synthesized using a cell… read more here.
Keywords: metabolic network; kluyveromyces lactis; transcriptional switch; lacto biose ... See more keywords
Integrated Metabolomics and Lipidomics Approach for the Study of Metabolic Network and Early Diagnosis in Cerebral Infarction.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.2c00348
Abstract: Cerebral infarction (CI) remains a major cause of high mortality and long-term disability worldwide. The exploration of biomarkers and pathogenesis is crucial for the early diagnosis of CI. Although the understanding of metabolic perturbations underlying… read more here.
Keywords: metabolic network; integrated metabolomics; metabolomics lipidomics; cerebral infarction ... See more keywords
A genome-scale metabolic network alignment method within a hypergraph-based framework using a rotational tensor-vector product
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-34692-1
Abstract: Biological network alignment aims to discover important similarities and differences and thus find a mapping between topological and/or functional components of different biological molecular networks. Then, the mapped components can be considered to correspond to… read more here.
Keywords: network alignment; network; framework; method ... See more keywords
Metabolic Network Models of the Gardnerella Pangenome Identify Key Interactions with the Vaginal Environment
Sign Up to like & getrecommendations! Published in 2022 at "mSystems"
DOI: 10.1128/msystems.00689-22
Abstract: Bacterial vaginosis (BV) is the most common vaginal infection among reproductive-age women. Despite its prevalence and associated chronic and acute women’s health impacts, the diverse bacteria involved in BV infection remain poorly characterized. Gardnerella is… read more here.
Keywords: metabolic network; environment; gardnerella; genus ... See more keywords
Reconstruction and analysis of a carbon-core metabolic network for Dunaliella salina
Sign Up to like & getrecommendations! Published in 2020 at "BMC Bioinformatics"
DOI: 10.1186/s12859-019-3325-0
Abstract: BackgroundThe green microalga Dunaliella salina accumulates a high proportion of β-carotene during abiotic stress conditions. To better understand the intracellular flux distribution leading to carotenoid accumulation, this work aimed at reconstructing a carbon core metabolic… read more here.
Keywords: salina; network; metabolic network; carbon core ... See more keywords
Visualizing metabolic network dynamics through time-series metabolomic data
Sign Up to like & getrecommendations! Published in 2020 at "BMC Bioinformatics"
DOI: 10.1186/s12859-020-3415-z
Abstract: Background New technologies have given rise to an abundance of -omics data, particularly metabolomic data. The scale of these data introduces new challenges for the interpretation and extraction of knowledge, requiring the development of innovative… read more here.
Keywords: network; visualization; time; series ... See more keywords
Elevated temperatures do not trigger a conserved metabolic network response among thermotolerant yeasts
Sign Up to like & getrecommendations! Published in 2019 at "BMC Microbiology"
DOI: 10.1186/s12866-019-1453-3
Abstract: BackgroundThermotolerance is a highly desirable trait of microbial cell factories and has been the focus of extensive research. Yeast usually tolerate only a narrow temperature range and just two species, Kluyveromyces marxianus and Ogataea polymorpha… read more here.
Keywords: temperatures trigger; network response; elevated temperatures; metabolic network ... See more keywords