Intercellular communications and metabolic reprogramming as new predictive markers for immunotherapy responses in gastric cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Communications"
DOI: 10.1002/cac2.12285
Abstract: Dear Editor, Immune-directed therapeutic approaches have changed the paradigm of cancer treatment. The tumor-immune microenvironment [1] is a dynamic milieu consisting of heterogeneous metabolic conditions such as low oxygen, nutrient deficiency, acidity, and interactions betweenmultiple… read more here.
Keywords: intercellular communications; metabolic reprogramming; differences metabolic; gastric cancer ... See more keywords
Energy Producing Metabolic Pathways in Functional Regulation of the Hematopoietic Stem Cells
Sign Up to like & getrecommendations! Published in 2018 at "IUBMB Life"
DOI: 10.1002/iub.1870
Abstract: The hematopoietic system has a very well‐studied hierarchy with the long‐term (LT) hematopoietic stem cells (HSCs) taking the top position. The pool of quiescent adult LT‐HSCs generated during the fetal and early postnatal life acts… read more here.
Keywords: energy; functional regulation; metabolic pathways; hematopoietic stem ... See more keywords
Proteomics Analysis Indicates Greater Abundance of Proteins Involved in Major Metabolic Pathways in Lactuca sativa cv. Salinas than Lactuca serriola Accession US96UC23
Sign Up to like & getrecommendations! Published in 2020 at "PROTEOMICS"
DOI: 10.1002/pmic.201900420
Abstract: Lettuce (Lactuca sativa), cultivated mainly for its edible leaves and stems, is an important vegetable crop worldwide. Genomes of cultivated lettuce (L. sativa cv. Salinas) and its wild relative L. serriola accession US96UC23 are sequenced,… read more here.
Keywords: sativa salinas; metabolic pathways; accession us96uc23; lactuca sativa ... See more keywords
Metabolic Reprogramming and Signaling to Chromatin Modifications in Tumorigenesis.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-34025-4_12
Abstract: Cellular proliferation relies on a high energetic status, replenished through nutrient intake, that leads to the production of biosynthetic material. A communication between the energetic levels and the control of gene expression is essential to… read more here.
Keywords: metabolic reprogramming; metabolic pathways; signaling chromatin; reprogramming signaling ... See more keywords
An overview of biochemically characterized drug targets in metabolic pathways of Leishmania parasite
Sign Up to like & getrecommendations! Published in 2020 at "Parasitology Research"
DOI: 10.1007/s00436-020-06736-x
Abstract: Leishmaniasis is a neglected tropical disease with no effective vaccines to date. Globally, it affects around 14 million people living in undeveloped and developing countries. Leishmania, which is the causative eukaryotic organism, possesses unique enzymes… read more here.
Keywords: drug targets; metabolic pathways; characterized drug; drug ... See more keywords
Identification of key genes associated with secondary metabolites biosynthesis by system network analysis in Valeriana officinalis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of plant research"
DOI: 10.1007/s10265-021-01277-5
Abstract: Valeriana officinalis is a medicinal plant, a source of bioactive chemical compounds and secondary metabolites which are applied in pharmaceutical industries. The advent of ethnomedicine has provided alternatives for disease treatment and has increased demands… read more here.
Keywords: metabolic pathways; valeriana officinalis; key genes; secondary metabolites ... See more keywords
The indispensable role of mammalian iron sulfur proteins in function and regulation of multiple diverse metabolic pathways
Sign Up to like & getrecommendations! Published in 2019 at "Biometals"
DOI: 10.1007/s10534-019-00191-7
Abstract: AbstractIn recent years, iron sulfur (Fe–S) proteins have been identified as key players in mammalian metabolism, ranging from long-known roles in the respiratory complexes and the citric acid cycle, to more recently recognized roles in… read more here.
Keywords: role mammalian; indispensable role; iron sulfur; metabolic pathways ... See more keywords
Diverse steroidogenic pathways in the marine alga Aurantiochytrium
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Applied Phycology"
DOI: 10.1007/s10811-020-02078-4
Abstract: The heterotrophic alga Aurantiochytrium accumulates a high amount of squalene, which is a key precursor to the biosynthesis of sterols and steroids. However, post-squalene sterol pathways of the algae have been enigmatic. Using NMR-based chemical… read more here.
Keywords: sterol metabolic; metabolic pathways; alga aurantiochytrium; aurantiochytrium ... See more keywords
Metabolic profiling of Drosophila melanogaster metamorphosis: a new insight into the central metabolic pathways
Sign Up to like & getrecommendations! Published in 2017 at "Metabolomics"
DOI: 10.1007/s11306-017-1167-1
Abstract: IntroductionMetamorphosis is a complicated process in which cell proliferation, differentiation, and death are orchestrated to form the mature structures of insects. In Drosophila, this process is controlled by ecdysone, a steroid hormone responsible for tissue… read more here.
Keywords: drosophila; central metabolic; metabolic profiling; metabolic pathways ... See more keywords
Global testing of shifts in metabolic phenotype
Sign Up to like & getrecommendations! Published in 2018 at "Metabolomics"
DOI: 10.1007/s11306-018-1435-8
Abstract: IntroductionCurrent metabolomics approaches to unravel impact of diet- or lifestyle induced phenotype variation and shifts predominantly deploy univariate or multivariate approaches, with a posteriori interpretation at pathway level. This however often provides only a fragmented… read more here.
Keywords: intervention; phenotype; metabolic phenotype; metabolic pathways ... See more keywords
Ferulic Acid Modulates Dysfunctional Metabolic Pathways and Purinergic Activities, While Stalling Redox Imbalance and Cholinergic Activities in Oxidative Brain Injury
Sign Up to like & getrecommendations! Published in 2019 at "Neurotoxicity Research"
DOI: 10.1007/s12640-019-00099-7
Abstract: The neuroprotective activities of phenolics have been demonstrated in several studies, with their antioxidant properties playing an influential role. In this study, the therapeutic effect of ferulic acid was investigated on oxidative stress, purinergic and… read more here.
Keywords: oxidative brain; metabolic pathways; ferulic acid; acid ... See more keywords