PHGDH preserves one-carbon cycle to confer metabolic plasticity in chemoresistant gastric cancer during nutrient stress.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2217826120
Abstract: Molecular classification of gastric cancer (GC) identified a subgroup of patients showing chemoresistance and poor prognosis, termed SEM (Stem-like/Epithelial-to-mesenchymal transition/Mesenchymal) type in this study. Here, we show that SEM-type GC exhibits a distinct metabolic profile… read more here.
Keywords: sem type; metabolic plasticity; gastric cancer;
Metabolic plasticity of Salmonella enterica as adaptation strategy in river water.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of environmental health research"
DOI: 10.1080/09603123.2021.1896682
Abstract: The survival of Salmonella in subtropical river water depends on genetic and metabolic reorganization for the expression of alternative metabolic pathways in response to starvation, which allows Salmonella to use environmental carbon sources (C-sources). However,… read more here.
Keywords: metabolic plasticity; plasticity salmonella; river water; salmonella ... See more keywords
Metabolic plasticity and regulation of T cell exhaustion
Sign Up to like & getrecommendations! Published in 2022 at "Immunology"
DOI: 10.1111/imm.13575
Abstract: The metabolic reprogramming during T cell activation and differentiation affects T cell fate and immune responses. Cell metabolism may serve as the driving force that induces epigenetic modifications, contributing to regulating T cell differentiation. Persistent… read more here.
Keywords: plasticity regulation; cell; metabolic plasticity; cell exhaustion ... See more keywords
Metabolic plasticity of mixotrophic algae is key for their persistence in browning environments
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Ecology"
DOI: 10.1111/mec.16619
Abstract: Light availability is the main regulator of primary production, shaping photosynthetic communities and their production of ecologically important biomolecules. In freshwater ecosystems, increasing dissolved organic carbon (DOC) concentrations, commonly known as browning, leads to lower… read more here.
Keywords: light availability; mixotrophic algae; metabolic plasticity; browning environments ... See more keywords
Efficient Mitochondrial Glutamine Targeting Prevails Over Glioblastoma Metabolic Plasticity
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-16-3102
Abstract: Purpose: Glioblastoma (GBM) is the most common and malignant form of primary human brain tumor in adults, with an average survival at diagnosis of 18 months. Metabolism is a new attractive therapeutic target in cancer;… read more here.
Keywords: metabolic plasticity; gbm; efficient mitochondrial; metabolic phenotyping ... See more keywords
Targeting Metabolic Plasticity and Flexibility Dynamics for Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-20-0844
Abstract: Cancer cells continuously rewire their metabolism to fulfill their need for rapid growth and survival while subject to changes in environmental cues. Thus, a vital component of a cancer cell lies in its metabolic adaptability.… read more here.
Keywords: therapy; plasticity flexibility; cancer; cancer therapy ... See more keywords
Metabolic Plasticity Enables Circadian Adaptation to Acute Hypoxia in Zebrafish Cells
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000489058
Abstract: Background/Aims: Reduced oxygen availability, hypoxia, is frequently encountered by organisms, tissues and cells, in aquatic environments as well as in high altitude or under pathological conditions such as infarct, stroke or cancer. The hypoxic signaling… read more here.
Keywords: metabolic plasticity; plasticity enables; hypoxia; acute hypoxia ... See more keywords
Metabolic plasticity for subcutaneous fat accumulation in a long-distance migratory bird traced by 2H2O
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Experimental Biology"
DOI: 10.1242/jeb.150490
Abstract: ABSTRACT The migrant black-tailed godwit (Limosa limosa) traditionally used natural wetlands in the Iberian Peninsula to prepare for migratory flights by feeding mainly in estuaries. In recent decades, this species has become increasingly dependent on… read more here.
Keywords: fat accumulation; metabolic plasticity; subcutaneous fat; black tailed ... See more keywords
Herbicides Tolerance in a Pseudomonas Strain Is Associated With Metabolic Plasticity of Antioxidative Enzymes Regardless of Selection
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2021.673211
Abstract: Agriculture uses many food production chains, and herbicides participate in this process by eliminating weeds through different biochemical strategies. However, herbicides can affect non-target organisms such as bacteria, which can suffer damage if there is… read more here.
Keywords: tolerance; metabolic plasticity; control; selection ... See more keywords
The metabolic plasticity of B cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.991188
Abstract: The humoral response requires rapid growth, biosynthetic capacity, proliferation and differentiation of B cells. These processes involve profound B-cell phenotypic transitions that are coupled to drastic changes in metabolism so as to meet the extremely… read more here.
Keywords: metabolic plasticity; plasticity cells; plasticity;
Energy Metabolic Plasticity of Colorectal Cancer Cells as a Determinant of Tumor Growth and Metastasis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.698951
Abstract: Metabolic plasticity is the ability of the cell to adjust its metabolism to changes in environmental conditions. Increased metabolic plasticity is a defining characteristic of cancer cells, which gives them the advantage of survival and… read more here.
Keywords: plasticity colorectal; metabolic plasticity; colorectal cancer; cancer cells ... See more keywords