Metabolic programming of the epigenome: host and gut microbial metabolite interactions with host chromatin
Sign Up to like & getrecommendations! Published in 2017 at "Translational Research"
DOI: 10.1016/j.trsl.2017.08.005
Abstract: &NA; The mammalian gut microbiota has been linked to host developmental, immunologic, and metabolic outcomes. This collection of trillions of microbes inhabits the gut and produces a myriad of metabolites, which are measurable in host… read more here.
Keywords: gut; metabolic programming; host; microbial metabolite ... See more keywords
Captivity-induced metabolic programming in an endangered felid: implications for species conservation
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-60577-3
Abstract: Reintroduction of captive-bred individuals into the wild is an important conservation activity. However, environmental conditions can influence developmental programming, potentially causing metabolic disorders in adults. These effects are investigated here for the first time in… read more here.
Keywords: programming; metabolic programming; wild born; captivity ... See more keywords
Maternal high-fat diet induces long-term obesity with sex-dependent metabolic programming of adipocyte differentiation, hypertrophy and dysfunction in the offspring.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical science"
DOI: 10.1042/cs20191229
Abstract: Maternal obesity determines obesity and metabolic diseases in the offspring. The white adipose tissue (WAT) orchestrates metabolic pathways, and its dysfunction contributes to metabolic disorders in a sex-dependent manner. Here, we tested if sex-differences influence… read more here.
Keywords: metabolic programming; sex dependent; obesity; dependent metabolic ... See more keywords
Starvation-induced changes in somatic insulin/IGF-1R signaling drive metabolic programming across generations
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.ade1817
Abstract: Exposure to adverse nutritional and metabolic environments during critical periods of development can exert long-lasting effects on health outcomes of an individual and its descendants. Although such metabolic programming has been observed in multiple species… read more here.
Keywords: metabolic programming; igf; starvation induced; across generations ... See more keywords